Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice

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Inhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2017.00615
P932PMC publication ID5447018
P698PubMed publication ID28611775

P50authorGabriel NussbaumQ88438546
P2093author name stringIrun R Cohen
Shira Dishon
Shmuel J Cohen
P2860cites workExperimental and natural infections in MyD88- and IRAK-4-deficient mice and humansQ37119134
Critical regulation of early Th17 cell differentiation by interleukin-1 signalingQ37250727
Targeting TLR/IL-1R signalling in human diseases.Q37731951
Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cellsQ39237839
IL-10 mediates resistance to adoptive transfer experimental autoimmune encephalomyelitis in MyD88(-/-) miceQ39769143
Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote EosinophiliaQ40869282
The type III secretion effector NleE inhibits NF-kappaB activationQ41893338
Alarming dendritic cells for Th2 inductionQ41953596
Signaling via MYD88 in the pancreatic tumor microenvironment: A double-edged sword.Q41971950
Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimerQ43615371
TLR4-mediated pro-inflammatory dendritic cell differentiation in humans requires the combined action of MyD88 and TRIF.Q45988450
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathwaysQ48219736
T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors.Q51835996
TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development.Q53875132
Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responsesQ58662838
Genetically Resistant Mice Lacking MyD88-Adapter Protein Display a High Susceptibility to Leishmania major Infection Associated with a Polarized Th2 ResponseQ59312651
Myeloid differentiation primary response gene 88 (MyD88) deficiency in a large kindredQ62111716
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cellsQ73035410
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiationQ74405327
TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor proteinQ80444357
Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}BQ81497841
Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammationQ81880345
The innate immune adaptor MyD88 is dispensable for spontaneous autoimmune demyelination in a mouse model of multiple sclerosisQ85792655
What the Myddosome structure tells us about the initiation of innate immunityQ24338472
Toll-like receptor signallingQ24570126
Pyogenic bacterial infections in humans with MyD88 deficiencyQ24653859
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signalingQ27655822
Synthesis of anemoclemoside B, the first natural product with an open-chain cyclic acetal glycosidic linkageQ28174937
Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88Q28481617
Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitisQ28591514
Differentiation of effector CD4 T cell populations (*)Q29614838
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cellsQ29618163
Antigen-independent IFN-γ production by human naïve CD4 T cells activated by IL-12 plus IL-18Q31009909
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejectionQ33187036
Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease.Q33886694
MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infectionQ34074728
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosisQ34312767
A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4Q34795980
The role of MyD88-like adapters in Toll-like receptor signal transductionQ35139387
Dendritic-cell control of pathogen-driven T-cell polarizationQ35597117
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejectionQ35939463
Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screenQ36098995
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells.Q36193536
Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft RejectionQ36223307
Absence of MyD88 signaling induces donor-specific kidney allograft toleranceQ36280335
Toll-like receptors: sentinels of host defence against bacterial infectionQ36327543
Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligationQ36370469
Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-beta1.Q36525918
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signalingQ36598193
Suppression of TLR signaling by targeting TIR domain-containing proteinsQ36676056
P921main subjectexperimental autoimmune encephalomyelitisQ494066
P304page(s)615
P577publication date2017-05-29
P1433published inFrontiers in ImmunologyQ27723748
P1476titleInhibition of Myeloid Differentiation Factor 88 Reduces Human and Mouse T-Cell Interleukin-17 and IFNγ Production and Ameliorates Experimental Autoimmune Encephalomyelitis Induced in Mice
P478volume8

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cites work (P2860)
Q55318936Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88.
Q92512115ERβ-selective agonist alleviates inflammation in a multiple sclerosis model via regulation of MHC II in microglia

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