Methotrexate-induced apoptosis in hepatocytes after partial hepatectomy

scientific article published in March 2002

Methotrexate-induced apoptosis in hepatocytes after partial hepatectomy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0014-2999(02)01264-5
P698PubMed publication ID11906706

P2093author name stringKaoru Kobayashi
Ikuyo Tsukamoto
Chieko Terada
P2860cites workJNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoformsQ24312029
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2Q24313872
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationQ24642901
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to developmentQ28268881
Apoptosis by death factorQ28304002
Retinoic acid repressed the expression of c-fos and c-jun and induced apoptosis in regenerating rat liver after partial hepatectomyQ28564781
AP-1 in cell proliferation and survivalQ29615217
Cell cycle control and cancerQ29617536
p53: puzzle and paradigmQ29618407
AP-1 function and regulationQ29618422
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-JunQ29620103
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domainQ29620169
Activation of Jun kinase is an early event in hepatic regenerationQ34202651
AP-1 in mouse development and tumorigenesisQ34279346
Liver regeneration. 2. Role of growth factors and cytokines in hepatic regenerationQ34368036
Phosphorylation of c-jun mediated by MAP kinases.Q34947174
Apoptosis induced by anticancer drugsQ35233723
Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cellsQ36563976
Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular agingQ36761547
Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domainQ37055760
Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activationQ37141859
Drug-target interactions: only the first step in the commitment to a programmed cell death?Q37188769
Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation.Q40300975
Apoptosis. Its significance in cancer and cancer therapyQ40739570
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Q41218044
MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?Q41345475
Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermiaQ41714603
Genetic determinants of p53-induced apoptosis and growth arrestQ42812233
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73Q42825163
Comparison of in vitro cell cytotoxic assays for tumor necrosis factorQ44180676
Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro.Q53541288
c-Jun is essential for normal mouse development and hepatogenesisQ57083732
Tumor necrosis factor primes hepatocytes for DNA replication in the ratQ58022178
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21Q59054204
Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomyQ74615819
Induction of apoptosis in neoplastic cells by depletion of vitamin B12Q82498461
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjecthepatectomyQ1514021
P304page(s)19-24
P577publication date2002-03-01
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleMethotrexate-induced apoptosis in hepatocytes after partial hepatectomy
P478volume438

Reverse relations

cites work (P2860)
Q42952495Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.
Q60300547Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study
Q36669837Effect of methotrexate exposure at late gestation on development of telencephalon in rat fetal brain
Q37120987Effect of methotrexate exposure at middle gestation on the inner plate of the ocular cup and lens in the rat fetus
Q35924108Effect of methotrexate on cerebellar development in infant rats
Q33579518Effect of methotrexate on neuroepithelium in the rat fetal brain
Q39569990Hepatoprotective efficacy of ursodeoxycholic acid in pediatrics acute lymphoblastic leukemia
Q35976422Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy
Q54751155Methotrexate is a novel inducer of rat liver and intestinal sulfotransferases
Q39025757Protective Effects of Thymoquinone against Methotrexate-Induced Germ Cell Apoptosis in Male Mice
Q36457546Revisiting the immunomodulators tacrolimus, methotrexate, and mycophenolate mofetil: their mechanisms of action and role in the treatment of IBD.
Q39537262The effect of N-acetylcysteine on the antitumor activity of ifosfamide
Q46758534Tumor suppressor protein p53 and anti-p53 autoantibodies in pediatric rheumatological diseases.

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