Interaction of the retinoblastoma gene product, RB, with cyclophilin A negatively affects cyclosporin-inhibited NFAT signaling

scientific article

Interaction of the retinoblastoma gene product, RB, with cyclophilin A negatively affects cyclosporin-inhibited NFAT signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCB.10253
P698PubMed publication ID12210730

P2093author name stringKazunari K Yokoyama
Robert Chiu
Li Zhu
Yukun Cui
Kirash Mirkia
Yu-Hsieh Florence Fu
P2860cites workRb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250Q22008567
RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrestQ24291072
The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processingQ24306341
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilinQ24338951
The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolinQ24561774
A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shockQ24648784
Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growthQ27939546
Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding siteQ28137644
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promotersQ28140428
Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localizationQ28143654
Transcription factors of the NFAT family: regulation and functionQ28237645
Retinoblastoma protein recruits histone deacetylase to repress transcriptionQ28262144
Retinoblastoma protein represses transcription by recruiting a histone deacetylaseQ28262155
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and JunQ28263918
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3pQ28276243
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexesQ28277749
Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activityQ28288097
70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retinoblastoma gene product pRb. Identification of a novel region of pRb-mediating protein interactionQ28297406
Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and BQ29618922
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activationQ29620223
Cyclophilin: a specific cytosolic binding protein for cyclosporin AQ29620548
Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytesQ33888899
Identification of a putative regulator of early T cell activation genesQ34171263
Functional association of cyclophilin A with HIV-1 virionsQ34326356
Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpressionQ36234059
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene productQ36439907
Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression.Q36574115
The retinoblastoma gene product regulates Sp1-mediated transcriptionQ36816438
Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility geneQ37474961
Specific incorporation of cyclophilin A into HIV-1 virionsQ38302257
The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulatorQ38306731
Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoterQ40412449
The retinoblastoma protein: more than a tumor suppressorQ40611429
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma proteinQ40656395
Rb protein down-regulates the stress-activated signals through inhibiting c-Jun N-terminal kinase/stress-activated protein kinase.Q40881898
Detection of a novel cell cycle-regulated kinase activity that associates with the amino terminus of the retinoblastoma protein in G2/M phasesQ41349328
Negative regulation of human c-fos expression by the retinoblastoma gene productQ41724715
The caspase-RB connection in cell deathQ46055131
P433issue4
P921main subjectretinoblastomaQ500695
P304page(s)630-641
P577publication date2002-01-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleInteraction of the retinoblastoma gene product, RB, with cyclophilin A negatively affects cyclosporin-inhibited NFAT signaling
P478volume86

Reverse relations

cites work (P2860)
Q35224208Cyclophilin A (CypA) interacts with NF-κB subunit, p65/RelA, and contributes to NF-κB activation signaling
Q39841617Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells
Q44765106Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cells
Q42610828Lower Malignancy Rates in Renal Allograft Recipients Converted to Sirolimus-Based, Calcineurin Inhibitor-Free Immunotherapy: 24-Month Results From the CONVERT Trial

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