scholarly article | Q13442814 |
P2093 | author name string | N. Frenkel | |
R. R. Spaete | |||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | virus | Q808 |
molecular cloning | Q408351 | ||
genetic vector | Q427389 | ||
vector-borne disease | Q2083837 | ||
amplicon | Q2844457 | ||
P304 | page(s) | 295-304 | |
P577 | publication date | 1982-08-01 | |
P1433 | published in | Cell | Q655814 |
P1476 | title | The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector | |
P478 | volume | 30 |
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Q37396712 | A DNA binding protein specific for an origin of replication of herpes simplex virus type 1. |
Q35222291 | A brief history of gene therapy |
Q43244050 | A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons |
Q37248409 | A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation |
Q36831621 | A host cell protein binds to a highly conserved sequence element (pac-2) within the cytomegalovirus a sequence. |
Q35873295 | A hybrid herpesvirus infectious vector based on Epstein-Barr virus and herpes simplex virus type 1 for gene transfer into human cells in vitro and in vivo |
Q37409686 | A method for identifying the viral genes required for herpesvirus DNA replication |
Q40547095 | A new method to propagate defective HSV-1 vectors |
Q36655306 | A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome |
Q36891387 | A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components |
Q40412983 | A truncated herpes simplex virus origin binding protein which contains the carboxyl terminal origin binding domain binds to the origin of replication but does not alter its conformation |
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Q37217245 | Advances in high-capacity extrachromosomal vector technology: episomal maintenance, vector delivery, and transgene expression. |
Q36256746 | Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene |
Q40571051 | Amplicon-based herpes simplex virus vectors. |
Q40390640 | Amplification of acidic endothelial cell growth factor (ECGF) gene sequences in hamster DDT1-MF2 tumor cells |
Q40137260 | An HSV-1 amplicon system for prostate-specific expression of ICP4 to complement oncolytic viral replication for in vitro and in vivo treatment of prostate cancer cells |
Q44858702 | An adenoviral vector expressing the glucose transporter protects cultured striatal neurons from 3-nitropropionic acid |
Q77106472 | An infectious transfer and expression system for genomic DNA loci in human and mouse cells |
Q40448525 | Analysis of Ori-S sequence of HSV-1: identification of one functional DNA binding domain. |
Q36822278 | Analysis of an origin of DNA replication located at the L terminus of the genome of pseudorabies virus |
Q40140792 | Analysis of gene expression using Simian Virus 40 vectors |
Q39782364 | Analysis of herpes simplex virus type 1 DNA packaging signal mutations in the context of the viral genome |
Q40106342 | Analysis of the herpes simplex virus type 1 OriS sequence: mapping of functional domains |
Q43934769 | Antitumor effects on human melanoma xenografts of an amplicon vector transducing the herpes thymidine kinase gene followed by ganciclovir |
Q40651385 | Application of an immunoperoxidase monolayer assay for the detection of arboviral antibodies |
Q50798624 | Assessment of a cellular vaccination approach consisting of crawling dendritic cells (CDCs) transduced with HSV-1-Deltapac vectors. |
Q36946568 | BK Virus-Plasmid Expression Vector That Persists Episomally in Human Cells and Shuttles into Escherichia coli |
Q38345181 | Binding of the herpes simplex virus type 1 UL9 gene product to an origin of viral DNA replication |
Q40065708 | Boundaries and structure of human cytomegalovirus oriLyt, a complex origin for lytic-phase DNA replication |
Q39874400 | Branched structures in the intracellular DNA of herpes simplex virus type 1. |
Q45236484 | Cell culture amplification of a defective Marek's disease virus |
Q36255482 | Cell engineering for muscle gene therapy: Extemporaneous production of retroviral vector packaging macrophages using defective herpes simplex virus type 1 vectors harbouring gag, pol, env genes |
Q33782614 | Cellular transcription factors enhance herpes simplex virus type 1 oriS-dependent DNA replication. |
Q39538972 | Characterisation of a human herpesvirus 6 variant A 'amplicon' and replication modulation by U94-Rep 'latency gene'. |
Q45797434 | Characterization of the TRs/IRS origin of DNA replication of herpes simplex virus Type 1 |
Q35885882 | Circularization and cleavage of guinea pig cytomegalovirus genomes |
Q40373850 | Circularization of the herpes simplex virus type 1 genome upon lytic infection |
Q40138262 | Class I defective herpes simplex virus DNA as a molecular cloning vehicle in eucaryotic cells |
Q36862725 | Cloning and characterization of oriL2, a large palindromic DNA replication origin of herpes simplex virus type 2. |
Q29030728 | Cloning human herpes virus 6A genome into bacterial artificial chromosomes and study of DNA replication intermediates |
Q36888407 | Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis |
Q43583250 | Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine. |
Q37193031 | Comparative analysis of human cytomegalovirus a-sequence in multiple clinical isolates by using polymerase chain reaction and restriction fragment length polymorphism assays. |
Q37784704 | Constitutive and Inducible Innate Responses in Cells Infected by HSV-1-Derived Amplicon Vectors |
Q36686357 | Construction and properties of a recombinant herpes simplex virus 1 lacking both S-component origins of DNA synthesis |
Q34464526 | Construction of an excisable bacterial artificial chromosome containing a full-length infectious clone of herpes simplex virus type 1: viruses reconstituted from the clone exhibit wild-type properties in vitro and in vivo |
Q38804605 | Construction of recombinant pseudorabies viruses by using PRV BACs deficient in IE180 or pac sequences: Application of vBAC90D recombinant virus to production of PRV amplicons. |
Q34074791 | Current status of viral gene therapy for brain tumours |
Q34070154 | Cytomegalovirus bacterial artificial chromosomes: a new herpesvirus vector approach |
Q40065369 | Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1 |
Q41559090 | DNA labeled during phosphonoacetate inhibition and following its reversal in herpesvirus infected cells |
Q35564463 | DNA sequence of the region in the genome of herpes simplex virus type 1 containing the genes for DNA polymerase and the major DNA binding protein. |
Q39879535 | Defective herpes simplex virus type 1 vectors harboring gag, pol, and env genes can be used to rescue defective retrovirus vectors |
Q40913368 | Defective viral vectors as agents for gene transfer in the nervous system |
Q35753517 | Development of herpesvirus-based episomally maintained gene delivery vectors |
Q37949279 | Development of new cell lines for animal cell biotechnology |
Q40699522 | Development of new expression vector based on Pseudorabies virus amplicons: application to human insulin expression |
Q45756222 | Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector: implications for a gene therapy approach to epilepsy |
Q80674687 | Early STAT1 activation after systemic delivery of HSV amplicon vectors suppresses transcription of the vector-encoded transgene |
Q35750430 | Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. |
Q45729782 | Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector |
Q33845102 | Effects of mutations within the herpes simplex virus type 1 DNA encapsidation signal on packaging efficiency |
Q40324547 | Efficient site-specific integration of large transgenes by an enhanced herpes simplex virus/adeno-associated virus hybrid amplicon vector |
Q62971299 | Engineering Herpes Simplex |
Q91652419 | Enhanced Production of Herpes Simplex Virus 1 Amplicon Vectors by Gene Modification and Optimization of Packaging Cell Growth Medium |
Q27480392 | Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system |
Q36683468 | Epstein-Barr virus (EBV) recombinants: use of positive selection markers to rescue mutants in EBV-negative B-lymphoma cells |
Q39881506 | Equimolar generation of the four possible arrangements of adjacent L components in herpes simplex virus type 1 replicative intermediates. |
Q45764657 | Expression of L1 in primary astrocytes via a defective herpes simplex virus vector promotes neurite outgrowth and neural cell migration |
Q39873071 | Expression of an equine herpesvirus 1 ICP22/ICP27 hybrid protein encoded by defective interfering particles associated with persistent infection. |
Q34363528 | Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses |
Q38307531 | Expression of the varicella-zoster virus origin-binding protein and analysis of its site-specific DNA-binding properties. |
Q40811145 | Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers |
Q31920166 | Flow cytometric assessment of transduction efficiency and cytotoxicity of herpes simplex virus type 1-based amplicon vectors |
Q40494835 | Fragments from both termini of the herpes simplex virus type 1 genome contain signals required for the encapsidation of viral DNA |
Q36867220 | Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA. |
Q40606308 | Functional expression of ATM gene carried by HSV amplicon vector in vitro and in vivo |
Q33781982 | Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6 |
Q36781706 | Functional mapping and DNA sequence of an equine herpesvirus 1 origin of replication. |
Q33210210 | Gene expression profiles associated with survival of individual rat dentate cells after endogenous corticosteroid deprivation |
Q34119491 | Gene therapy for Parkinson's disease: review and update |
Q37610257 | Gene therapy for malignant brain tumors |
Q34997896 | Gene therapy for the central nervous system in the lysosomal storage disorders |
Q33837123 | Gene therapy in the CNS. |
Q44493199 | Gene transfer and in vivo promoter analysis of the rat progesterone receptor using a herpes simplex virus viral vector |
Q39581687 | Gene transfer into the nervous system |
Q44241094 | Gene transfer of NMDAR1 subunit sequences to the rat CNS using herpes simplex virus vectors interfered with habituation. |
Q39211259 | Generation of high-titer defective HSV-1 vectors |
Q39989655 | Generation of high-titer defective HSV-1 vectors |
Q36908014 | Genetic and phenotypic analysis of herpes simplex virus type 1 mutants conditionally resistant to immune cytolysis |
Q36832257 | Genetic evidence for multiple nuclear functions of the herpes simplex virus ICP8 DNA-binding protein |
Q44916386 | HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype |
Q40746235 | HSV-1 amplicon vectors |
Q36897379 | HSV-1 amplicon vectors: a promising and versatile tool for gene delivery. |
Q39974606 | HSV-1 amplicon viral vector-mediated gene transfer to human bone marrow-derived mesenchymal stem cells. |
Q58995392 | HSV-1 as a Model for Emerging Gene Delivery Vehicles |
Q36288901 | HSV-1-based amplicon vectors: design and applications |
Q33995752 | HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part II. Vector systems and applications |
Q37528088 | HSV-1-derived amplicon vectors: recent technological improvements and remaining difficulties--a review |
Q35870965 | Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells. |
Q40604183 | Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. |
Q39923388 | Herpes Virus Amplicon Vectors |
Q33846286 | Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products |
Q34699896 | Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machinery |
Q33634580 | Herpes simplex virus DNA replication: the UL9 gene encodes an origin-binding protein |
Q36859541 | Herpes simplex virus amplicon: cleavage of concatemeric DNA is linked to packaging and involves amplification of the terminally reiterated a sequence. |
Q36918697 | Herpes simplex virus amplicon: effect of size on replication of constructed defective genomes containing eucaryotic DNA sequences |
Q36792982 | Herpes simplex virus induces the replication of foreign DNA. |
Q40132227 | Herpes simplex virus infection generates large tandemly reiterated simian virus 40 DNA molecules in a transformed hamster cell line. |
Q36780584 | Herpes simplex virus type 1 DNA synthesis requires the product of the UL8 gene: isolation and characterization of an ICP6::lacZ insertion mutation |
Q36780130 | Herpes simplex virus type 1 gene products required for DNA replication: identification and overexpression. |
Q34070145 | Herpes simplex virus type 1-based amplicon vector systems |
Q42448457 | Herpes simplex virus type 1/adeno-associated virus hybrid vectors |
Q34341823 | Herpes simplex virus type 1/adeno-associated virus hybrid vectors mediate site-specific integration at the adeno-associated virus preintegration site, AAVS1, on human chromosome 19. |
Q34341816 | Herpes simplex virus type 1/adeno-associated virus rep(+) hybrid amplicon vector improves the stability of transgene expression in human cells by site-specific integration |
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Q45788035 | Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects |
Q40599511 | Herpes simplex virus vectors for gene therapy |
Q35863367 | Herpes simplex virus-based vectors |
Q39320351 | Herpesvirus Capsid Assembly and DNA Packaging. |
Q40852248 | Herpesviruses: expression of genes in postmitotic brain cells |
Q39601616 | Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. |
Q44528496 | Hippocampal infection with HSV-1-derived vectors expressing an NMDAR1 antisense modifies behavior |
Q39872953 | Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains. |
Q24800764 | Human cytomegalovirus plasmid-based amplicon vector system for gene therapy |
Q35881706 | Identification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7. |
Q45806757 | Identification of a gene function of herpes simplex virus type 1 essential for amplification of simian virus 40 DNA sequences in transformed hamster cells |
Q36655634 | Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29. |
Q48637450 | Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. |
Q36826810 | Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis |
Q35852638 | Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity |
Q37392882 | Immune responses to herpesviral vectors |
Q35131218 | Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy |
Q48489387 | In situ PCR for in vivo detection of foreign genes transferred into rat brain |
Q45882772 | In vivo episomal maintenance of a herpesvirus saimiri-based gene delivery vector |
Q45467028 | In vivo gene transfer to the rat retina using herpes simplex virus type 1 (HSV-1)-based amplicon vectors |
Q57020987 | In vivo methods for acute modulation of gene expression in the central nervous system |
Q37689072 | Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase |
Q39839678 | Infection with herpes simplex type 1-based amplicon vectors results in an IRF3/7-dependent, TLR-independent activation of the innate antiviral response in primary human fibroblasts |
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Q36825714 | Isolation and characterization of herpes simplex virus type 1 host range mutants defective in viral DNA synthesis |
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