Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

scientific article published on 26 May 2009

Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/HYPERTENSIONAHA.109.130005
P698PubMed publication ID19470880
P5875ResearchGate publication ID26242326

P50authorGeorge Davey SmithQ21003878
Nicholas J. TimpsonQ30348324
Børge G. NordestgaardQ43530123
Anne Tybjærg-HansenQ52932605
Roger HarbordQ56530195
Jeppe ZachoQ114322644
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthypertensionQ95566669
P304page(s)84-90
P577publication date2009-05-26
P1433published inHypertensionQ5958695
P1476titleDoes greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype
P478volume54

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cites work (P2860)
Q34703780ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes
Q37691400Adiposity and Blood Pressure in 110 000 Mexican Adults
Q35958369Adiposity and blood pressure among 55 000 relatively lean rural adults in southwest of China
Q36208982Age and sex-specific associations of anthropometric measures of adiposity with blood pressure and hypertension in India: a cross-sectional study
Q33737082Are there socioeconomic inequalities in cardiovascular risk factors in childhood, and are they mediated by adiposity? Findings from a prospective cohort study
Q28541037Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis
Q59808757Association of Age-Related Trends in Blood Pressure and Body Composition Indices in Healthy Adults
Q38692743Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study
Q53091867Association of an apolipoprotein E polymorphism with circulating cholesterols and hypertension: a meta-based Mendelian randomization analysis.
Q55428280Association of anthropometric measures and cardiovascular risk factors in children and adolescents: Findings from the Aboriginal Birth Cohort study.
Q30827986Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis
Q37023991Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts
Q48962631Associations of obesity susceptibility loci with hypertension in Chinese children
Q57788631BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization
Q36107656Blood pressure in relation to general and central adiposity among 500 000 adult Chinese men and women
Q38727619Body Mass Index and Risk of Alzheimer Disease: a Mendelian Randomization Study of 399,536 Individuals
Q30248778Body mass index: Has epidemiology started to break down causal contributions to health and disease?
Q36666879C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization
Q30411394Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis
Q96132970Chronic Kidney Disease Modifies The Relationship Between Body Fat Distribution and Blood Pressure: A Cross-Sectional Analysis
Q35764701Circulating interleukin-6 and cancer: A meta-analysis using Mendelian randomization
Q48717468Coffee intake, cardiovascular disease and all-cause mortality: observational and Mendelian randomization analyses in 95 000-223 000 individuals
Q36754486Combined effects of FTO rs9939609 and MC4R rs17782313 on elevated nocturnal blood pressure in the Chinese Han population
Q45742041Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention
Q47185011Comparative associations between anthropometric and bioelectric impedance analysis derived adiposity measures with blood pressure and hypertension in India: a cross-sectional analysis
Q33717771Complex Relationship between Obesity and the Fat Mass and Obesity Locus
Q28716745Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world
Q36413693Consumption of high-polyphenol dark chocolate improves endothelial function in individuals with stage 1 hypertension and excess body weight
Q35020898Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study
Q36006147Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions
Q61847258Detecting and correcting for bias in Mendelian randomization analyses using Gene-by-Environment interactions
Q44705838Dietary calcium intake and its relationship with adiposity and metabolic profile in hypertensive patients
Q35232423Dietary counseling on long-term weight loss in overweight hypertensive patients
Q36384352Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium
Q37014533Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension
Q92570410Epicardial Adipose Tissue Accumulation and Essential Hypertension in Non-Obese Adults
Q92328834Epidemiology, genetic epidemiology and Mendelian randomisation: more need than ever to attend to detail
Q33737610Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment
Q51163456Epigenetic patterns of two gene promoters (TNF-α and PON) in stroke considering obesity condition and dietary intake.
Q37355062Estimating Marginal Healthcare Costs Using Genetic Variants as Instrumental Variables: Mendelian Randomization in Economic Evaluation
Q34547712Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004.
Q57104944Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study
Q60922033Factors associated with the severity of hypertension among Malaysian adults
Q36596543Genetic influences on trajectories of systolic blood pressure across childhood and adolescence
Q36949317Genetic instrumental variable studies of effects of prenatal risk factors
Q36629966Genetic markers as instrumental variables
Q35107260Genetics of Obesity: What have we Learned?
Q47568885Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications
Q102220492Genomics of hypertension: the road to precision medicine
Q40809311High body mass index and cancer risk-a Mendelian randomisation study
Q34731154Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension
Q95264108Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies
Q30907369Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults
Q33570112Lack of association between DRD2 and OPRM1 genotypes and adiposity
Q33939241Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts
Q47251605Lose weight with traditional chinese medicine? Potential suppression of fat mass and obesity-associated protein
Q63727933Low vitamin D and hypertension: a causal association?
Q24289296MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization
Q35026645Manifestation of renal disease in obesity: pathophysiology of obesity-related dysfunction of the kidney
Q37914949Mechanisms linking obesity to hypertension.
Q21296811Mendelian Randomisation Study of Childhood BMI and Early Menarche
Q54877750Mendelian Randomization: Using Natural Genetic Variation to Assess the Causal Role of Modifiable Risk Factors in Observational Studies.
Q34615295Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance
Q26999349Mendelian randomization studies: a review of the approaches used and the quality of reporting
Q37967484Mendelian randomization: application to cardiovascular disease
Q37671737Mendelian randomization: applications and limitations in epigenetic studies
Q27002487Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Q48456096Mendelian randomization: where are we now and where are we going?
Q37387339Metabolic cardiovascular risk factors worsen continuously across the spectrum of body mass index in Asian Indians
Q28542592Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change
Q35034381Mining the human phenome using allelic scores that index biological intermediates
Q36824063Neuroimmune communication in hypertension and obesity: a new therapeutic angle?
Q34017275Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei.
Q83576180Obesity is a strong determinant of hypertensive target organ damage in young-to-middle-age patients
Q46814792On the choice of parameterisation and priors for the Bayesian analyses of Mendelian randomisation studies.
Q28655080Phenotype refinement strengthens the association of AHR and CYP1A1 genotype with caffeine consumption
Q41838684Physiological adaptations to resistance exercise as a function of age.
Q40468883Prognostic Value of Ambulatory Blood Pressure in the Obese: The Ambulatory Blood Pressure-International Study.
Q35628131Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population
Q37607640Prospective associations between problematic eating attitudes in midchildhood and the future onset of adolescent obesity and high blood pressure
Q48166924Relation between adiposity and vascular events, malignancy and mortality in patients with stable cerebrovascular disease
Q61847245Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization
Q53108096Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies.
Q50216476Short-term Effects of Green Tea on Blood Pressure, Endothelial Function, and Metabolic Profile in Obese Prehypertensive Women: A Crossover Randomized Clinical Trial
Q36847998Sleep epidemiology--a rapidly growing field
Q42695959Software Application Profile: PHESANT: a tool for performing automated phenome scans in UK Biobank.
Q31042331The Role of DNA Methylation in Cardiovascular Risk and Disease: Methodological Aspects, Study Design, and Data Analysis for Epidemiological Studies.
Q33552952The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study
Q24562954The bigger picture of FTO: the first GWAS-identified obesity gene
Q48664002The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study
Q85317814The common SNP (rs9939609) in the FTO gene modifies the association between obesity and high blood pressure in Chinese children
Q28730188The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach
Q41885752The effect of fat mass on educational attainment: examining the sensitivity to different identification strategies
Q83936416The prevalence of obesity-related hypertension and risk for new vascular events in patients with vascular diseases
Q28681102The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis
Q87026094The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity
Q35832781Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease.
Q33586820Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach
Q34581653Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health
Q33858805Usefulness of Mendelian randomization in observational epidemiology
Q57106334Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults
Q27014012Vitamin D status and hypertension: a review

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