Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release

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Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M402155200
P698PubMed publication ID15136572
P5875ResearchGate publication ID8568535

P50authorWilliam C. SessaQ64680365
David FultonQ88410298
P2093author name stringYasuko Iwakiri
Jason Fontana
Lisette Acevedo
Roger Babbitt
Stefan Zoellner
Timothy J McCabe
P2860cites workRegulation of endothelium-derived nitric oxide production by the protein kinase AktQ22010149
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Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1Q28296135
Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signalingQ28609890
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinaseQ30439814
Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic proteinQ30464616
Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targetingQ33722544
A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteinsQ33859187
Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.Q33950554
Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.Q34158412
Ras pathway signaling on endomembranesQ35089365
Functional Expression of Endothelial Nitric Oxide Synthase Fused to Green Fluorescent Protein in Transgenic MiceQ35792234
Nitric oxide synthase is localized predominantly in the Golgi apparatus and cytoplasmic vesicles of vascular endothelial cellsQ36680797
Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesisQ37368066
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cellsQ37376612
Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cellsQ37416665
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cellsQ37628594
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor.Q39821682
Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increaseQ40622130
Receptor-Regulated Dynamic Interaction between Endothelial Nitric Oxide Synthase and Calmodulin Revealed by Fluorescence Resonance Energy Transfer in Living CellsQ40628809
Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide productionQ40638231
Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivoQ40730346
Basal and stimulated protein S-nitrosylation in multiple cell types and tissuesQ40756642
Endothelial nitric oxide synthase activity is linked to its presence at cell-cell contactsQ40759918
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme.Q40765690
Vesicle budding on Golgi membranes: regulation by G proteins and myosin motorsQ40845647
Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cellsQ40849536
Trafficking of endothelial nitric-oxide synthase in living cells. Quantitative evidence supporting the role of palmitoylation as a kinetic trapping mechanism limiting membrane diffusion.Q40938612
Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localizationQ41158636
Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolaeQ41215934
Myristoylation of endothelial cell nitric oxide synthase is important for extracellular release of nitric oxideQ41269678
Role of the enzyme calmodulin-binding domain in membrane association and phospholipid inhibition of endothelial nitric oxide synthaseQ41334662
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membraneQ41718569
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthaseQ42437220
Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthaseQ43559341
Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cellsQ43559410
Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cellsQ43559665
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulationQ43599368
The GRIP domain is a specific targeting sequence for a population of trans-Golgi network derived tubulo-vesicular carriers.Q43605992
Endothelial nitric oxide synthase and its negative regulator caveolin-1 localize to distinct perinuclear organellesQ43999127
Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthaseQ44110016
Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complexQ44473651
Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP.Q44595338
Production of PtdInsP3 at endomembranes is triggered by receptor endocytosisQ44607820
A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPasesQ48014886
P433issue29
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)30349-30357
P577publication date2004-05-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleTargeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release
P478volume279

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