Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide.

scientific article published on 14 July 2008

Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/BJP.2008.289
P932PMC publication ID2579672
P698PubMed publication ID18622409
P5875ResearchGate publication ID5228846

P50authorMaria Dolores Herrera GonzalezQ70473430
Rosalia Rodriguez-RodriguezQ80515391
P2093author name stringL Ostergaard
M R Andersen
U Simonsen
E Stankevicius
V Ruiz-Gutierrez
P2860cites workEffects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial.Q55042163
Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylationQ57219989
AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human plateletsQ60760894
Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stressQ71720438
Estrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells. Effects on calcium sensitivity and NO releaseQ73441789
Role of intracellular calcium for noradrenaline-induced depolarization in rat mesenteric small arteriesQ74243614
Flow- and acetylcholine-induced dilatation in small arteries from rats with renovascular hypertension--effect of tempol treatmentQ80272360
Pomace olive oil improves endothelial function in spontaneously hypertensive rats by increasing endothelial nitric oxide synthase expressionQ80515393
Regulation of endothelium-derived nitric oxide production by the protein kinase AktQ22010149
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylationQ22010150
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stressQ24555749
Adherence to a Mediterranean diet and survival in a Greek populationQ34208988
Ion channels and their functional role in vascular endotheliumQ34388070
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthaseQ35026148
Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide productionQ35044232
Red wine polyphenols induce EDHF-mediated relaxations in porcine coronary arteries through the redox-sensitive activation of the PI3-kinase/Akt pathwayQ35047460
Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinasesQ35192636
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cellsQ35218922
Combination of Ca2+ -activated K+ channel blockers inhibits acetylcholine-evoked nitric oxide release in rat superior mesenteric artery.Q36054413
Physiologically relevant measurements of nitric oxide in cardiovascular research using electrochemical microsensorsQ36308679
Scientific evidence of interventions using the Mediterranean diet: a systematic reviewQ36419427
Endothelium-derived hyperpolarizing factor: where are we now?Q36423629
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme.Q40765690
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).Q40799734
Nitric oxide in the vasculature: physiology and pathophysiologyQ41500552
Different modulation by Ca2+-activated K+ channel blockers and herbimycin of acetylcholine- and flow-evoked vasodilatation in rat mesenteric small arteries.Q41784962
Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein.Q42456094
Growth hormone increases vascular cell adhesion molecule 1 expression: in vivo and in vitro evidenceQ42456756
Ca2+-independent activation of the endothelial nitric oxide synthase in response to tyrosine phosphatase inhibitors and fluid shear stressQ42543420
Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertensionQ44425953
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heartQ44532391
Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide releaseQ44891136
Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-AktQ45029420
Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aortaQ45135732
Phospholipase d signaling and extracellular signal-regulated kinase-1 and -2 phosphorylation (activation) are required for maximal phorbol ester-induced transglutaminase activity, a marker of keratinocyte differentiationQ45146923
Determination of oleanolic acid in human plasma and study of its pharmacokinetics in Chinese healthy male volunteers by HPLC tandem mass spectrometryQ46673318
Reduction of NO- and EDHF-mediated vasodilatation in hypertension: role of asymmetric dimethylarginineQ46906686
Triterpenic compounds from "orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive ratsQ46989907
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulationQ47322285
Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed.Q50774676
In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery.Q54103479
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)535-546
P577publication date2008-07-14
P1433published inBritish Journal of PharmacologyQ919631
P1476titleOleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide
P478volume155

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cites work (P2860)
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Q45947826Effects of pomace olive oil-enriched diets on endothelial function of small mesenteric arteries from spontaneously hypertensive rats.
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