Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure (scientific article published on 7 September 2004)

Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines

Q24675224

Blockade of human atrial 5-HT4 receptors by GR 113808

Q24685748

Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays

Q28140044

Expression of serotonin receptor mRNAs in blood vessels

Q28296354

The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants

Q28368220

Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant

Q28369138

5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle

Q32059490

Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR.

Q33951364

Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants

Q34105746

5-HT4 receptors

Q34298897

Electrophysiological effects of 5‐hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic β‐adrenoceptor blockade

Q35045973

Labelling with [125I]‐SB 207710 of a small 5‐HT4 receptor population in piglet right atrium: functional relevance

Q35872895

A 5-hydroxytryptamine receptor in human atrium

Q35888122

5-Hydroxytryptamine stimulates human isolated atrium but not ventricle

Q38566087

The Regulation of Contractile Activity in Muscle

Q39893178

Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart

Q40037475

Do human atrial 5-HT4 receptors mediate arrhythmias?

Q40610626

Serotonin increases calcium current in human atrial myocytes via the newly described 5-hydroxytryptamine4 receptors

Q41082809

Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts

Q41346387

Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation

Q41701470

Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).

Q42460996

Use of a synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity ratio in a variety of tissues

Q42794111

Piglet sinoatrial 5-HT receptors resemble human atrial 5-HT4-like receptors

Q43570922

Positive inotropic response to 5-HT in human atrial but not in ventricular heart muscle

Q43771222

Relationship between myocardial remodeling and neurohumoral activation in patients with cardiac failure

Q43771848

A 5-HT4-like receptor in human right atrium.

Q53858263

L-type calcium channel activity in human atrial myocytes as influenced by 5-HT.

Q54042506

Effect of 5-HT4 receptor stimulation on the pacemaker current If in human isolated atrial myocytes

Q63321134

Serotonin metabolism in the normal and failing hamster heart

Q66940483

A 5-HT4-like receptor in human left atrium

Q67491258

5-Hydroxytryptamine increases contractile force in porcine right atrium but not in left ventricle

Q67971691

5-HT4 receptors, present in piglet atria and sensitive to SDZ 205-557, are absent in papillary muscle

Q67975615

Endocardium modulates myocardial inotropic response to 5-hydroxytryptamine

Q69413794

Comparison of the densities of 5-HT4 receptors, beta 1- and beta 2-adrenoceptors in human atrium: functional implications

Q71345794

Sensitization of Human Atrial 5-HT 4 Receptors by Chronic β-Blocker Treatment

Q71807715

Serotonergic mechanisms in heart failure

Q72590601

5-Hydroxytryptamine causes rate-dependent arrhythmias through 5-HT4 receptors in human atrium: facilitation by chronic beta-adrenoceptor blockade

Q72688184

Blockade of human atrial 5-HT4 receptors by SB 207710, a selective and high affinity 5-HT4 receptor antagonist

Q72688960

Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscle

Q73045813

Analysis of gene expression patterns in small amounts of human ventricular myocardium by a multiplex RNase protection assay

Q74310511

Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure

Q77781940

P433

issue

P921

main subject

serotonin

Q167934

heart failure

Q181754

P304

page(s)

157-166

P577

publication date

2004-09-07

P1433

published in

Naunyn-Schmiedeberg's Archives of Pharmacology

Q1468251

P1476

title

Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure

P478

volume

370

Reverse relations

cites work (P2860)

Q61819782	(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through β2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling
Q41139399	5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Q36514263	5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT).
Q35563508	Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle
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Q45164756	Altered platelet contents in survivors of early ischemic ventricular fibrillation: preliminary findings
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Q85910177	Regulation of GAPDH expression by treatment with the β-adrenoceptor agonist isoprenaline--is GADPH a suitable loading control in immunoblot experiments?
Q46950614	Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
Q86035071	Surprises from a cardiac 5-HT₄TG mouse: spontaneous atrial arrhythmias by endogenous 5-HT of atrial origin? Different mechanism of arrhythmias through 5-HT₄ receptors and β-adrenoceptors?
Q34166903	Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders
Q34429191	The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure
Q34993925	The expanded biology of serotonin
Q36835728	beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current
Q55257365	cAMP Catalyzing Phosphodiesterases Control Cholinergic Muscular Activity But Their Inhibition Does Not Enhance 5-HT4 Receptor-Mediated Facilitation of Cholinergic Contractions in the Murine Gastrointestinal Tract.

P6179	Dimensions Publication ID	1047340328
P356	DOI	10.1007/S00210-004-0963-0
P698	PubMed publication ID	15365689