STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

scientific article published on 13 February 2005

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1045716994
P356DOI10.1038/NI1172
P698PubMed publication ID15711548
P5875ResearchGate publication ID8020764

P50authorHergen SpitsQ89927093
Ferenc A. ScheerenQ43211580
Sean A. DiehlQ54438130
P2093author name stringErwin Wijnands
Remko Schotte
Bianca Blom
Marianne Naspetti
Ramon Gimeno
Maho Nagasawa
Florry A Vyth-Dreese
P2860cites workPlasma cell differentiation requires the transcription factor XBP-1Q24291453
Transcriptional analysis of the B cell germinal center reactionQ24554209
IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cellsQ57599600
Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40-mediated proliferation and survival pathwaysQ73084759
Ligation of CD27 on murine B cells responding to T-dependent and T-independent stimuli inhibits the generation of plasma cellsQ73306773
A system for stable expression of short interfering RNAs in mammalian cellsQ27860875
Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivoQ28143201
Regulatory mechanisms that determine the development and function of plasma cellsQ28202747
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression programQ28216493
Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cellsQ28252567
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 geneQ28276209
Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activityQ28383134
Disruption of the Bcl6 gene results in an impaired germinal center formationQ28509600
Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cellsQ28510456
Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiationQ28511315
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammationQ28584806
Control of inflammation, cytokine expression, and germinal center formation by BCL-6Q28585541
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responsesQ28592023
Jaks and STATs: biological implicationsQ29619657
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signalingQ30828170
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.Q33183255
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytesQ34009928
Arrested differentiation, the self-renewing memory lymphocyte, and vaccination.Q34307999
The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune responseQ36365985
Characterization of the Promoter Region of Human BCL-6 GeneQ38291544
DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sitesQ38307243
Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.Q40836930
Constitutive activation of STAT5 by a point mutation in the SH2 domainQ40878082
The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5.Q40897726
The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chainQ40995235
Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiationQ41115163
Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40Q41700086
Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cellsQ41712990
Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2Q42759511
Memory B cells are biased towards terminal differentiation: a strategy that may prevent repertoire freezingQ42951748
Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.Q42951830
Ligation of CD27 on B cells in vivo during primary immunization enhances commitment to memory B cell responsesQ44666509
Multiple myeloma related cells in patients undergoing autologous peripheral blood stem cell transplantationQ47974316
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.Q52004102
Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre.Q52024998
Generation of memory B cells and plasma cells in vitro.Q52053106
BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.Q55034216
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.Q55066450
Localization in situ of the co-stimulatory molecules B7.1, B7.2, CD40 and their ligands in normal human lymphoid tissueQ56909299
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmemory B cellQ1195394
P304page(s)303-313
P577publication date2005-02-13
P1433published inNature ImmunologyQ1071725
P1476titleSTAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression
P478volume6

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