Disruption of the Bcl6 gene results in an impaired germinal center formation

scientific journal article

Disruption of the Bcl6 gene results in an impaired germinal center formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.186.3.439
P3181OpenCitations bibliographic resource ID988447
P932PMC publication ID2199007
P698PubMed publication ID9236196
P5875ResearchGate publication ID25873849

P2093author name stringT. Yoshida
S. Okabe
K. Ishibashi
T. Miki
H. Koseki
M. Taniguchi
N. Miyasaka
S. Hirosawa
S. Okada
T. Fukuda
T. Tokuhisa
M. Hatano
P2860cites workBCL-6 protein is expressed in germinal-center B cellsQ24324053
The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in DrosophilaQ24562764
The POZ domain: a conserved protein-protein interaction motifQ28115868
LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomasQ28255448
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphomaQ28256118
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleenQ28300225
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formationQ28586300
RAG-1-deficient mice have no mature B and T lymphocytesQ28592133
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune reQ28594116
Germinal centersQ29616234
Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cellsQ71854871
Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphomaQ72327581
Mice deficient for the CD40 ligandQ72610555
Distinct pathways of B cell differentiation. I. Residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibodyQ72670275
AN AUTORADIOGRAPHIC STUDY OF THE GERMINAL CENTER IN SPLEEN WHITE PULP DURING EARLY INTERVALS OF THE IMMUNE RESPONSEQ76846938
Analysis of somatic mutation in five B cell subsets of human tonsilQ34328629
The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.Q34415305
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populationsQ34885732
CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.Q35962812
The path of memory B-cell developmentQ36171744
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centersQ36231790
The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary responseQ36354168
Antibody response to a T-dependent antigen requires B cell expression of complement receptorsQ36366376
Mutant mice without B lymphocyte folliclesQ36367422
The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene.Q36669935
Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Krüppel-like zinc-finger proteinQ36759209
BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressorQ37477121
Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.Q37626496
BCL6 encodes a sequence‐specific DNA‐binding ProteinQ38293781
Recognition DNA sequence of a novel putative transcription factor, BCL6.Q38303448
Transcriptional repression by the proto-oncogene BCL-6.Q38356856
Mechanism and regulation of immunoglobulin isotype switching.Q40850235
In situ studies of the germinal center reactionQ40973828
Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development.Q41062386
Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centersQ41092267
Intraclonal generation of antibody mutants in germinal centresQ41172275
Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias.Q41497101
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-toleranceQ41888015
The BCL6 gene is predominantly expressed in keratinocytes at their terminal differentiation stageQ42526807
CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotypeQ42706157
Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectorsQ42805800
Germinal centers develop oligoclonallyQ43487651
Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigensQ43603650
IgG response is impaired in H2-c-fos transgenic miceQ45343424
Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.Q45980652
Antigen-induced B-cell death and elimination during germinal-centre immune responsesQ46147419
BCL-6 expression during B-cell activationQ48063185
Locus-specific somatic hypermutation in germinal centre T cellsQ48077130
Maturation of the immune response in germinal centersQ48194763
CD28 is required for germinal center formation.Q52047631
Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.Q52053087
Generation of memory B cells and plasma cells in vitro.Q52053106
Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?Q52122457
LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients.Q52514761
Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.Q52519424
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.Q54167674
BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts.Q55065145
CD40 ligand-transduced co-stimulation of T cells in the development of helper functionQ58882277
Alternative pathways for the selection of antigen-specific peripheral T cellsQ60089786
Role of lymphotoxin and the type I TNF receptor in the formation of germinal centersQ71095987
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectB cell leukemia/lymphoma 6Q21428928
P304page(s)439–448
P577publication date1997-08-04
P1433published inJournal of Experimental MedicineQ3186912
P1476titleDisruption of the Bcl6 gene results in an impaired germinal center formation
P478volume186

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