| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0014-5793(96)01146-5 |
| P698 | PubMed publication ID | 8946945 |
| P2093 | author name string | Montal M | |
| Schubert U | |||
| Henklein P | |||
| Strebel K | |||
| Ferrer-Montiel AV | |||
| Oblatt-Montal M | |||
| P2860 | cites work | Calcium channel activity of purified human synexin and structure of the human synexin gene | Q24613441 |
| Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export | Q24644301 | ||
| Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments | Q24646897 | ||
| The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation | Q24676509 | ||
| Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones | Q28211190 | ||
| Complete nucleotide sequence of the AIDS virus, HTLV-III | Q28259080 | ||
| Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone | Q29547734 | ||
| Design of Molecular Function: Channels of Communication | Q30193776 | ||
| Induction of endogenous channels by high levels of heterologous membrane proteins in Xenopus oocytes | Q34047170 | ||
| Viral and cellular small integral membrane proteins can modify ion channels endogenous to Xenopus oocytes | Q34047519 | ||
| Identification of a protein encoded by the vpu gene of HIV-1. | Q34163678 | ||
| Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties | Q34211339 | ||
| Influenza virus M2 protein has ion channel activity | Q34248853 | ||
| The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif | Q34335638 | ||
| Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II | Q34352096 | ||
| Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes | Q35852056 | ||
| Acetylcholine receptor in planar lipid bilayers. Characterization of the channel properties of the purified nicotinic acetylcholine receptor from Torpedo californica reconstituted in planar lipid bilayers | Q36408986 | ||
| Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: the cytoplasmic domain of CD4 contributes to Vpu sensitivity | Q36649813 | ||
| Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein | Q36651564 | ||
| The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release | Q36800610 | ||
| Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein | Q36830393 | ||
| Structural characteristics of the M2 protein of influenza A viruses: evidence that it forms a tetrameric channel | Q41177473 | ||
| Maturation of influenza A virus hemagglutinin--estimates of the pH encountered during transport and its regulation by the M2 protein | Q41603952 | ||
| A novel gene of HIV-1, vpu, and its 16-kilodalton product | Q42656133 | ||
| Solution structure of the cytoplasmic domain of the human immunodeficiency virus type 1 encoded virus protein U (Vpu). | Q45769256 | ||
| Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds | Q45852640 | ||
| Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment | Q45867009 | ||
| Solution structure of the hydrophilic region of HIV-1 encoded virus protein U (Vpu) by CD and lH NMR spectroscopy | Q57013669 | ||
| Bundles of amphipathic transmembrane alpha-helices as a structural motif for ion-conducting channel proteins: studies on sodium channels and acetylcholine receptors | Q68494553 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | transmembrane protein | Q424204 |
| P304 | page(s) | 12-18 | |
| P577 | publication date | 1996-11-01 | |
| P1433 | published in | FEBS Letters | Q1388051 |
| P1476 | title | Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells | |
| P478 | volume | 398 |
| Q45420106 | A single amino acid substitution within the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein renders simian-human immunodeficiency virus (SHIV(KU-1bMC33)) susceptible to rimantadine |
| Q36675739 | Alterations in intracellular potassium concentration by HIV-1 and SIV Nef. |
| Q33807551 | Antiviral activity of the interferon-induced cellular protein BST-2/tetherin |
| Q42146940 | Application of solid-state NMR restraint potentials in membrane protein modeling |
| Q57243789 | Assembling an ion channel: ORF 3a from SARS-CoV |
| Q44993875 | Assembling viral channel forming proteins: Vpu from HIV-1. |
| Q28544943 | Atomistic detailed mechanism and weak cation-conducting activity of HIV-1 Vpu revealed by free energy calculations |
| Q34905536 | BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action |
| Q43628285 | Background K(2P) channels KCNK3/9/15 limit the budding of cell membrane-derived vesicles. |
| Q35291655 | Bacteria-based analysis of HIV-1 Vpu channel activity |
| Q59358796 | Beyond Channel Activity: Protein-Protein Interactions Involving Viroporins |
| Q40310467 | Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein |
| Q56775080 | Biophysical characterization of Vpu from HIV-1 suggests a channel-pore dualism |
| Q34112765 | Biophysical investigations of membrane perturbations by polypeptides using solid-state NMR spectroscopy (review). |
| Q33782459 | CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway |
| Q31037469 | Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride |
| Q52536989 | Cell surface CD4 inhibits HIV-1 particle release by interfering with Vpu activity. |
| Q44033298 | Chemical synthesis and single channel properties of tetrameric and pentameric TASPs (template-assembled synthetic proteins) derived from the transmembrane domain of HIV virus protein u (Vpu). |
| Q59177818 | Chlorella viruses evoke a rapid release of K+ from host cells during the early phase of infection |
| Q30322199 | Combining hydrophobicity and helicity: a novel approach to membrane protein structure prediction. |
| Q37781488 | Comparative NMR studies demonstrate profound differences between two viroporins: p7 of HCV and Vpu of HIV-1 |
| Q31028141 | Conformation and environment of channel-forming peptides: a simulation study |
| Q27647751 | Conformational changes induced by a single amino acid substitution in thetrans-membrane domain of Vpu: Implications for HIV-1 susceptibility to channel blocking drugs |
| Q64287253 | Coronavirus envelope protein: current knowledge |
| Q36744298 | Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1. |
| Q34423336 | Degranulation of Natural Killer Cells Following Interaction with HIV-1-Infected Cells Is Hindered by Downmodulation of NTB-A by Vpu |
| Q35217966 | Demonstrating the intrinsic ion channel activity of virally encoded proteins |
| Q40336343 | Dengue virus PrM/M proteins fail to show pH-dependent ion channel activity in Xenopus oocytes |
| Q34416492 | Determinants of tetherin antagonism in the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein |
| Q42211475 | Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4⁺ T cells |
| Q30391763 | Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins. |
| Q44619422 | Evidence That HIV Budding in Primary Macrophages Occurs through the Exosome Release Pathway |
| Q36639042 | Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1 |
| Q31032820 | Full length Vpu from HIV-1: combining molecular dynamics simulations with NMR spectroscopy |
| Q27473109 | Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. |
| Q33737672 | Functional domains within the human immunodeficiency virus type 2 envelope protein required to enhance virus production |
| Q40551267 | Fusion of the upstream vpu sequences to the env of simian human immunodeficiency virus (SHIV(KU-1bMC33)) results in the synthesis of two envelope precursor proteins, increased numbers of virus particles associated with the cell surface and is pathog |
| Q21245114 | Gene expression profiling of monkeypox virus-infected cells reveals novel interfaces for host-virus interactions |
| Q30910278 | Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein |
| Q36857081 | HIV accessory genes Vif and Vpu. |
| Q41421578 | HIV accessory proteins as therapeutic targets |
| Q37375080 | HIV accessory proteins versus host restriction factors |
| Q34033122 | HIV accessory proteins: multifunctional components of a complex system. |
| Q38951336 | HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins |
| Q37384691 | HIV-1 Vpu - an ion channel in search of a job. |
| Q39175785 | HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A. |
| Q40036254 | HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes |
| Q30815492 | HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane |
| Q24619066 | HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms |
| Q37860404 | Hepatitis C virus p7: molecular function and importance in hepatitis C virus life cycle and potential antiviral target. |
| Q35089609 | How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles |
| Q42413673 | Human immunodeficiency virus (HIV-1) Vpr induced downregulation of NHE1 induces alteration in intracellular pH and loss of ERM complex in target cells |
| Q33638667 | Impact of histidine residues on the transmembrane helices of viroporins |
| Q48674586 | In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV. |
| Q34474244 | Inflammasomes as mediators of immunity against influenza virus |
| Q33842032 | Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity |
| Q36898892 | Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence |
| Q33540597 | Interactions of alpha-helices with lipid bilayers: a review of simulation studies |
| Q40042729 | Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV. |
| Q39538757 | Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317. |
| Q37801586 | Ion channels as antivirus targets |
| Q52237512 | Ion channels: molecular modeling and simulation studies. |
| Q42208785 | Ion flux in the lung: virus-induced inflammasome activation |
| Q41927990 | Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription |
| Q37988058 | Mechanism of function of viral channel proteins and implications for drug development |
| Q73055727 | Membrane interactions and alignment of structures within the HIV-1 Vpu cytoplasmic domain: effect of phosphorylation of serines 52 and 56 |
| Q34134682 | Membrane potential depolarization as a triggering mechanism for Vpu-mediated HIV-1 release. |
| Q35214569 | Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence |
| Q47959607 | Models and simulations of ion channels and related membrane proteins |
| Q37307754 | Modulation of the severe CD4+ T-cell loss caused by a pathogenic simian-human immunodeficiency virus by replacement of the subtype B vpu with the vpu from a subtype C HIV-1 clinical isolate |
| Q40236457 | Molecular Dynamics Simulations on the First Two Helices of Vpu from HIV-1 |
| Q30717224 | Molecular dynamics investigation of membrane-bound bundles of the channel-forming transmembrane domain of viral protein U from the human immunodeficiency virus HIV-1. |
| Q30332722 | Molecular dynamics simulation of human immunodeficiency virus protein U (Vpu) in lipid/water Langmuir monolayer. |
| Q35040322 | Molecular dynamics simulations reveal the HIV-1 Vpu transmembrane protein to form stable pentamers |
| Q39642301 | Mutational analysis of the human immunodeficiency virus type 1 Vpu transmembrane domain that promotes the enhanced release of virus-like particles from the plasma membrane of mammalian cells. |
| Q28257691 | Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel |
| Q44426365 | Naturally occurring amino acid substitutions in the HIV-2 ROD envelope glycoprotein regulate its ability to augment viral particle release. |
| Q38752518 | Novel Acylguanidine-Based Inhibitor of HIV-1. |
| Q57971518 | ORF8a of SARS-CoV forms an ion channel: Experiments and molecular dynamics simulations |
| Q40087952 | Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein--a genetic, biochemical and biophysical analysis |
| Q34389186 | Oligomerization state and supramolecular structure of the HIV‐1 Vpu protein transmembrane segment in phospholipid bilayers |
| Q40896861 | Patch formation of a viral channel forming protein within a lipid membrane--Vpu of HIV-1. |
| Q38766720 | Pathophysiological Consequences of Calcium-Conducting Viroporins |
| Q93081405 | Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins |
| Q33933111 | Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity |
| Q56786857 | Positive Selection on HIV Accessory Proteins and the Analysis of Molecular Adaptation After Interspecies Transmission |
| Q66679193 | Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays |
| Q34141302 | Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages |
| Q111291645 | Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium |
| Q37950254 | Protein intrinsic disorder as a flexible armor and a weapon of HIV-1. |
| Q36548529 | Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse |
| Q33640055 | Regulation of virus release by the macrophage-tropic human immunodeficiency virus type 1 AD8 isolate is redundant and can be controlled by either Vpu or Env. |
| Q26823195 | Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis |
| Q33926185 | Requirements of the membrane proximal tyrosine and dileucine-based sorting signals for efficient transport of the subtype C Vpu protein to the plasma membrane and in virus release |
| Q34151000 | Respiratory syncytial virus (RSV) G glycoprotein is not necessary for vaccine-enhanced disease induced by immunization with formalin-inactivated RSV. |
| Q60046078 | Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1 |
| Q80966892 | SARS coronavirus E protein forms cation-selective ion channels |
| Q40405593 | Scrambling of the amino acids within the transmembrane domain of Vpu results in a simian-human immunodeficiency virus (SHIVTM) that is less pathogenic for pig-tailed macaques. |
| Q35591789 | Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors |
| Q35383228 | Separable determinants of subcellular localization and interaction account for the inability of group O HIV-1 Vpu to counteract tetherin |
| Q35033777 | Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release |
| Q77109300 | Simulation of the HIV-1 Vpu transmembrane domain as a pentameric bundle |
| Q27664759 | Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations |
| Q57971526 | Structural implications of mutations assessed by molecular dynamics: Vpu1–32 from HIV-1 |
| Q79443299 | Structure, dynamics and topology of membrane polypeptides by oriented 2H solid-state NMR spectroscopy |
| Q35217961 | Structure-function correlates of Vpu, a membrane protein of HIV-1. |
| Q40366740 | Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques |
| Q35176339 | T cell signaling and apoptosis in HIV disease |
| Q37928913 | Targeting human immunodeficiency virus type 1 assembly, maturation and budding. |
| Q38796348 | Targeting the Channel Activity of Viroporins. |
| Q35206874 | The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release. |
| Q28742774 | The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism |
| Q34976916 | The NB Protein of Influenza B Virus Is Not Necessary for Virus Replication In Vitro |
| Q34021500 | The Vpu protein: new concepts in virus release and CD4 down-modulation |
| Q48793768 | The alphavirus 6K protein activates endogenous ionic conductances when expressed in Xenopus oocytes |
| Q33647793 | The amino-terminal region of Vpr from human immunodeficiency virus type 1 forms ion channels and kills neurons. |
| Q33683328 | The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors |
| Q21245050 | The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu |
| Q27477454 | The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives |
| Q36377062 | The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an early step in the biosynthesis of major histocompatibility complex (MHC) class I molecules |
| Q24670601 | The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors |
| Q29619540 | The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein |
| Q37619619 | The minimalist architectures of viroporins and their therapeutic implications. |
| Q44572420 | The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques |
| Q43639895 | The structure of the HIV-1 Vpu ion channel: modelling and simulation studies. |
| Q40008929 | The vpu protein of human immunodeficiency virus type 1 plays a protective role against virus-induced apoptosis in primary CD4(+) T lymphocytes |
| Q27642299 | Three-dimensional Structure of the Channel-forming Trans-membrane Domain of Virus Protein “u” (Vpu) from HIV-1 |
| Q42620862 | Towards a mechanism of function of the viral ion channel Vpu from HIV-1. |
| Q57971554 | Transmembrane domains of viral ion channel proteins: A molecular dynamics simulation study |
| Q77796127 | Two models of the influenza A M2 channel domain: verification by comparison |
| Q34173884 | Using death to one's advantage: HIV modulation of apoptosis |
| Q79231572 | Validation of coronavirus E proteins ion channels as targets for antiviral drugs |
| Q47576154 | Viral Short ORFs and Their Possible Functions |
| Q37764974 | Viral channel forming proteins - modeling the target |
| Q30383828 | Viral channel forming proteins--How to assemble and depolarize lipid membranes in silico. |
| Q37505647 | Viral channel-forming proteins. |
| Q58374332 | Viral ion channel proteins in model membranes: a comparative study by X-ray reflectivity |
| Q33536851 | Viral ion channels: molecular modeling and simulation |
| Q34623321 | Viral ion channels: structure and function. |
| Q35151120 | Viral miniproteins |
| Q39603635 | Viral protein U (Vpu)-mediated enhancement of human immunodeficiency virus type 1 particle release depends on the rate of cellular proliferation |
| Q37755567 | Viral proteins function as ion channels. |
| Q34258402 | Viral replication is enhanced by an HIV-1 intersubtype recombination-derived Vpu protein. |
| Q38009617 | Viral targets of acylguanidines |
| Q90198276 | Viroporins and inflammasomes: A key to understand virus-induced inflammation |
| Q37202578 | Viroporins customize host cells for efficient viral propagation |
| Q34230206 | Viroporins. |
| Q38023155 | Viroporins: structure and biological functions. |
| Q44080429 | Virus ion channels |
| Q26801489 | Vpu Protein: The Viroporin Encoded by HIV-1 |
| Q24644811 | Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism |
| Q37115275 | Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion |
| Q35217957 | Vpu from HIV-1 on an atomic scale: experiments and computer simulations. |
| Q33638829 | Vpu increases susceptibility of human immunodeficiency virus type 1-infected cells to fas killing. |
| Q33455532 | Vpu matchmakers as a therapeutic strategy for HIV infection |
| Q40436581 | Vpu-mediated CD4 down-regulation and degradation is conserved among highly divergent SIV(cpz) strains |
| Q40149831 | vpu transmembrane peptide structure obtained by site-specific fourier transform infrared dichroism and global molecular dynamics searching |
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