Improving mass accuracy of high performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry of intact antibodies

scientific article published on 21 April 2006

Improving mass accuracy of high performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry of intact antibodies is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1031055926
P356DOI10.1016/J.JASMS.2006.02.023
P698PubMed publication ID16631376
P5875ResearchGate publication ID7150101

P2093author name stringPavel V Bondarenko
Thomas M Dillon
Himanshu S Gadgil
Gary D Pipes
Michael J Treuheit
P2860cites workSignal peptide prediction based on analysis of experimentally verified cleavage sitesQ24645296
Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrityQ27640312
Therapeutic antibodies for human diseases at the dawn of the twenty-first centuryQ34168125
Pyroglutamic acid. Non-metabolic formation, function in proteins and peptides, and characteristics of the enzymes effecting its removalQ38584564
Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture.Q40450635
Stability and CTL activity of N-terminal glutamic acid containing peptidesQ40794811
Electrospray ionization mass spectrometry: Deconvolution by an Entropy-Based algorithmQ45295921
Reversed-phase liquid chromatography/mass spectrometry analysis of reduced monoclonal antibodies in pharmaceuticsQ46811900
Effect of glycosylation on antibody function: implications for genetic engineeringQ46879419
Optimization of a reversed-phase high-performance liquid chromatography/mass spectrometry method for characterizing recombinant antibody heterogeneity and stabilityQ46920795
Cell-free synthesis of amino-terminal L-pyroglutamic acidQ47889412
Analysis of glutamine, glutamic acid and pyroglutamic acid in protein hydrolysates by high-performance liquid chromatographyQ69860676
Amino terminal sequences of human immunoglobulin heavy chainsQ70642099
Validation of a peptide mapping method for a therapeutic monoclonal antibody: what could we possibly learn about a method we have run 100 times?Q73524714
P433issue6
P921main subjectantibodyQ79460
high-performance liquid chromatographyQ381233
electrospray ionizationQ902061
P304page(s)867-872
P577publication date2006-04-21
P1433published inJournal of the American Society for Mass SpectrometryQ3020250
P1476titleImproving mass accuracy of high performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry of intact antibodies
P478volume17

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cites work (P2860)
Q46541519Accumulation of succinimide in a recombinant monoclonal antibody in mildly acidic buffers under elevated temperatures
Q53595800Cancer vaccine characterization: from bench to clinic.
Q50860928Combination of SDS-PAGE and intact mass analysis for rapid determination of heterogeneities in monoclonal antibody therapeutics.
Q81792390Comparison of LC and LC/MS methods for quantifying N-glycosylation in recombinant IgGs
Q94503762Computational Studies on the Mechanisms of Nonenzymatic Intramolecular Cyclization of the Glutamine Residues Located at N-Termini Catalyzed by Inorganic Phosphate Species
Q55872037Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)
Q49090078Detecting monoclonal immunoglobulins in human serum using mass spectrometry
Q64247340Dilute-and-shoot analysis of therapeutic monoclonal antibody variants in fermentation broth: a method capability study
Q43278365Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.
Q44031303MS in the analysis of biosimilars
Q46905334Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-Orbitrap mass spectrometer
Q51791478Molecular mass analysis of antibodies by on-line SEC-MS.
Q34080417Physicochemical and biological characterization of 1E10 anti-idiotype vaccine.
Q54768263Quantification of an intact monoclonal antibody, rituximab, by (RP)HPLC/DAD in compliance with ICH guidelines.
Q38062785The impact of mass spectrometry on the study of intact antibodies: from post-translational modifications to structural analysis.
Q39080325Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry

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