Computational Studies on the Mechanisms of Nonenzymatic Intramolecular Cyclization of the Glutamine Residues Located at N-Termini Catalyzed by Inorganic Phosphate Species

scientific article published on 13 April 2020

Computational Studies on the Mechanisms of Nonenzymatic Intramolecular Cyclization of the Glutamine Residues Located at N-Termini Catalyzed by Inorganic Phosphate Species is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/ACSOMEGA.9B04384
P932PMC publication ID7191561
P698PubMed publication ID32363268

P2093author name stringKoichi Kato
Akifumi Oda
Eiji Kurimoto
Tomoki Nakayoshi
P2860cites workSignal peptide prediction based on analysis of experimentally verified cleavage sitesQ24645296
Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptorsQ27628512
An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytesQ28301310
Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR SpectroscopyQ28550062
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-betaQ30319511
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditionsQ30320504
Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradationQ30406473
Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cellsQ30850332
Rapid on-membrane proteolytic cleavage for Edman sequencing and mass spectrometric identification of proteinsQ33225677
Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residuesQ34059219
N-terminal glutamate to pyroglutamate conversion in vivo for human IgG2 antibodiesQ34719565
Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central coreQ35660682
Heterogeneity of monoclonal antibodiesQ36935493
Amino acid sequence of the beta chain of human fibrinogen: homology with the gamma chainQ37583259
A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregatesQ39424641
Amyloid Plaque in the Human Brain Can Decompose from Aβ(1-40/1-42) by Spontaneous Nonenzymatic ProcessesQ40024784
Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfersQ40932694
Cyclic analogs of luteinizing hormone-releasing hormone with significant biological activitiesQ40968996
Racemization of the Succinimide Intermediate Formed in Proteins and Peptides: A Computational Study of the Mechanism Catalyzed by Dihydrogen Phosphate IonQ41613730
Succinimide Formation from an NGR-Containing Cyclic Peptide: Computational Evidence for Catalytic Roles of Phosphate Buffer and the Arginine Side ChainQ41981559
Ectodomain shedding generates Neoepitopes on collagen XVII, the major autoantigen for bullous pemphigoid.Q42477420
Computational insight into the mechanism of serine residue racemizationQ43011465
Glutaminyl cyclases display significant catalytic proficiency for glutamyl substratesQ43239720
Specific catalysis of asparaginyl deamidation by carboxylic acids: kinetic, thermodynamic, and quantitative structure-property relationship analysesQ43863484
Role of phosphate and carboxylate ions in maillard browningQ44768070
Kinetic study of racemization of aspartyl residues in synthetic elastin peptidesQ45122910
Improving mass accuracy of high performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry of intact antibodiesQ46091062
Deamidation of asparagine residues: direct hydrolysis versus succinimide-mediated deamidation mechanisms.Q46157873
The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chainsQ46548727
Computational evidence for the catalytic mechanism of glutaminyl cyclase. A DFT investigationQ46602224
Formation of pyroglutamic acid from N-terminal glutamic acid in immunoglobulin gamma antibodiesQ46628201
Reversed-phase liquid chromatography/mass spectrometry analysis of reduced monoclonal antibodies in pharmaceuticsQ46811900
Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer's diseaseQ47133483
Comparison of the activation energy barrier for succinimide formation from α- and β-aspartic acid residues obtained from density functional theory calculationsQ47228054
High-yield deblocking of amino termini of recombinant immunoglobulins with pyroglutamate aminopeptidaseQ47869327
The beta chain of chicken fibrinogen contains an atypical thrombin cleavage siteQ48229416
Synthesis and biological activity of some analogs of the gonadotropin releasing hormoneQ48576266
Receptors for thyrotropin-releasing hormone in prolactin producing rat pituitary cells in culture.Q48631878
Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brainQ48917681
Synthesis and relationship of L-glutaminyl-L-histidyl-L-prolinamide to the thyrotropin releasing hormoneQ48923192
Phosphate-Catalyzed Succinimide Formation from Asp Residues: A Computational Study of the Mechanism.Q51766352
Conformation-dependent racemization of aspartyl residues in peptides.Q51919448
Kinetic study of racemization of aspartyl residues in model peptides of alpha A-crystallin.Q52300136
Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.Q53203663
beta-amyloid is different in normal aging and in Alzheimer disease.Q53271609
Analysis of post-translational modifications in recombinant monoclonal antibody IgG1 by reversed-phase liquid chromatography/mass spectrometry.Q53539714
Receptor-binding affinities and biological activities of analogs of thyrotropin-releasing hormone in prolactin-producing pituitary cells in culture.Q54671185
Phosphate-Catalyzed Succinimide Formation from an NGR-Containing Cyclic Peptide: A Novel Mechanism for Deammoniation of the Tetrahedral IntermediateQ58696582
Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the geneQ67279868
Amino acid sequence of the amino-terminal region of calf skin collagenQ69359465
Stabilization of Lysozyme against Irreversible Inactivation by Suppression of Chemical ReactionsQ71941845
Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brainQ73067058
Intervertebral disc collagen. Usage of the short form of the alpha1(IX) chain in bovine nucleus pulposusQ73327528
Determination of the origin of the N-terminal pyro-glutamate variation in monoclonal antibodies using model peptidesQ79351990
Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation developmentQ79860325
Characterization of the stability of a fully human monoclonal IgG after prolonged incubation at elevated temperatureQ83213152
Development of cyclic NGR peptides with thioether linkage: structure and dynamics determining deamidation and bioactivityQ86648975
Possible Mechanisms of Nonenzymatic Formation of Dehydroalanine Residue Catalyzed by Dihydrogen Phosphate IonQ92648348
Computational Studies on the Nonenzymatic Deamidation Mechanisms of Glutamine ResiduesQ92942477
P433issue16
P304page(s)9162-9170
P577publication date2020-04-13
P1433published inACS OmegaQ27727647
P1476titleComputational Studies on the Mechanisms of Nonenzymatic Intramolecular Cyclization of the Glutamine Residues Located at N-Termini Catalyzed by Inorganic Phosphate Species
P478volume5

Search more.