Sclerostin deficiency is linked to altered bone composition

scientific article published in October 2014

Sclerostin deficiency is linked to altered bone composition is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JBMR.2259
P698PubMed publication ID24753092
P5875ResearchGate publication ID261726684

P50authorEleftherios P PaschalisQ91454626
Andreas RoschgerQ91538468
Socrates E PapapoulosQ92748124
Klaus KlaushoferQ99631558
Paul RoschgerQ114775796
Sonja GamsjaegerQ42409183
P2093author name stringIna Kramer
Michaela Kneissel
Antoon van Lierop
Norbert Hassler
Sonja Lueger
P2860cites workFTIR microspectroscopic analysis of normal human cortical and trabecular boneQ46292104
Age-related deterioration in trabecular bone mechanical properties at material level: nanoindentation study of the femoral neck in women by using AFM.Q47243224
Size-dependent heterogeneity benefits the mechanical performance of boneQ57031407
Transmenopausal changes in trabecular bone qualityQ57164616
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)Q24290838
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing proteinQ24536172
In situ characterisation of a microorganism surface by Raman microspectroscopy: the shell of Ascaris eggsQ29540617
Raman Assessment of Bone QualityQ30465076
Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathwayQ31032805
Spatial variation in osteonal bone properties relative to tissue and animal age.Q33408274
Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adultsQ33415776
Sclerostin: current knowledge and future perspectivesQ33992612
Materials become insensitive to flaws at nanoscale: lessons from natureQ34195073
Age-dependence of power spectral density and fractal dimension of bone mineralized matrix in atomic force microscope topography images: potential correlates of bone tissue age and bone fragility in female femoral neck trabeculae.Q34402472
Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation.Q34590956
Nanoscale heterogeneity promotes energy dissipation in bone.Q34630299
Infrared assessment of bone quality: a reviewQ35078785
Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient miceQ35156214
Decreased bone turnover and deterioration of bone structure in two cases of pycnodysostosisQ35740740
FTIR microspectroscopic analysis of human iliac crest biopsies from untreated osteoporotic bone.Q36893198
Bone mineralization density distribution in health and disease.Q37039215
Combination of nanoindentation and quantitative backscattered electron imaging revealed altered bone material properties associated with femoral neck fragilityQ37380294
Matrix mineralization as a trigger for osteocyte maturationQ38529341
Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone.Q38552681
Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2.Q39143854
Mineralized collagen fibrils: a mechanical model with a staggered arrangement of mineral particlesQ40171280
An electron microscopic study on the presence of proteoglycans in the mineralized matrix of rat and human compact lamellar boneQ41809876
Raman microspectroscopic mapping studies of human bronchial tissueQ42471099
Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopyQ43069821
Structural analysis of glycosaminoglycans and proteoglycans by means of Raman microspectrometryQ46124074
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strengthQ46186977
Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae.Q46274544
Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation.Q46274626
Decorin modulates matrix mineralization in vitroQ46287140
Effects of vertebral bone fragility and bone formation rate on the mineralization levels of cancellous bone from white femalesQ46287296
P433issue10
P304page(s)2144-2151
P577publication date2014-10-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titleSclerostin deficiency is linked to altered bone composition
P478volume29

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cites work (P2860)
Q35850452Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif
Q51666670Bone Matrix Composition Following PTH Treatment is Not Dependent on Sclerostin Status.
Q38364893Bone's Material Constituents and their Contribution to Bone Strength in Health, Disease, and Treatment.
Q88868240Confocal laser scanning microscopy-a powerful tool in bone research
Q58574005Cortical bone properties in the Brtl/+ mouse model of Osteogenesis imperfecta as evidenced by acoustic transmission microscopy
Q30713102Effect of anti-sclerostin therapy and osteogenesis imperfecta on tissue-level properties in growing and adult mice while controlling for tissue age.
Q34543980Estrogens and Androgens in Skeletal Physiology and Pathophysiology
Q26764854From disease to treatment: from rare skeletal disorders to treatments for osteoporosis
Q52867182HBM Mice Have Altered Bone Matrix Composition and Improved Material Toughness.
Q38807230Role and mechanism of action of sclerostin in bone
Q26750713Sclerostin Inhibition in the Management of Osteoporosis
Q42364116Sclerostin antibodies in osteoporosis: latest evidence and therapeutic potential
Q36253807Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model
Q64928492Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition.
Q55051527Sost Deficiency does not Alter Bone's Lacunar or Vascular Porosity in Mice.
Q52804786Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice.
Q52664558Treatment with anti-Sclerostin antibody to stimulate mandibular bone formation.