GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons

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GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons is …
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scholarly articleQ13442814

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P356DOI10.1093/ALCALC/AGV094
P698PubMed publication ID26271115

P50authorLuca FerraroQ38548471
P2093author name stringSergio Tanganelli
Tiziana Antonelli
Sarah Beggiato
Antonella Loche
Andrea C Borelli
Maria C Tomasini
Roberto Cacciaglia
P2860cites workReview. Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortexQ24641980
Glutamate and neurotrophic factors in neuronal plasticity and diseaseQ24653626
Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonismQ24674309
The hippocampal-prefrontal pathway: the weak link in psychiatric disorders?Q26822528
Wernicke encephalopathy and ethanol-related syndromesQ30804105
Clinical and pathological features of alcohol-related brain damageQ33870945
Cognitive impairments in alcohol-dependent subjectsQ33906958
Nalmefene for the treatment of alcohol dependence: a current updateQ34038952
Alcohol and adult hippocampal neurogenesis: promiscuous drug, wanton effectsQ34053689
Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in miceQ34172781
Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptorsQ34248546
Widespread and sustained cognitive deficits in alcoholism: a meta-analysisQ34248590
Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicityQ34280435
Pathways to alcohol-induced brain impairment in young people: a review.Q34334701
Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex.Q34337562
Cognitive control in alcohol use disorder: deficits and clinical relevanceQ34351761
Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo.Q34582262
Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonistsQ35015002
Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73Q35755149
Upregulated vimentin suggests new areas of neurodegeneration in a model of an alcohol use disorder.Q35818187
Specific Conditions for Resveratrol Neuroprotection against Ethanol-Induced ToxicityQ36065291
A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometryQ36143764
Withdrawal-associated increases and decreases in functional neural connectivity associated with altered emotional regulation in alcoholismQ36174088
Dissociated primary nerve cell cultures as models for assessment of neurotoxicityQ36300506
Reduced hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidityQ36502059
Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addictionQ36732795
DNA damage and neurotoxicity of chronic alcohol abuseQ36937215
Mechanism of alcohol-induced oxidative stress and neuronal injuryQ37020121
Phospholipase A2, oxidative stress, and neurodegeneration in binge ethanol-treated organotypic slice cultures of developing rat brainQ37399417
Nrf2 and antioxidant defense against CYP2E1 toxicityQ37577903
Acute and chronic effects of ethanol on learning-related synaptic plasticity.Q37581600
The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic propertiesQ38122179
Activation of NF-kappaB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP(+) toxicity in SK-N-SH cells.Q40032801
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodiesQ40150743
Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary culture.Q42911706
The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptorsQ44666716
Hippocampal volumes and cognitive functions in adult alcoholic patients with adolescent-onsetQ45127034
Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission.Q46681399
Neuroprotective effects of NMDA and group I metabotropic glutamate receptor antagonists against neurodegeneration induced by homocysteine in rat hippocampus: in vivo study.Q48093115
GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor.Q48093143
Effects of ethanol on excitatory and inhibitory synaptic transmission in rat cortical neuronsQ48317747
Ethanol induces MAP2 changes in organotypic hippocampal slice culturesQ48341464
Long-term alcohol self-administration and alcohol withdrawal differentially modulate microtubule-associated protein 2 (MAP2) gene expression in the rat brainQ48351482
GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5.Q48646646
Chronic ethanol treatment alters ω-conotoxin and Bay K 8644 sensitive calcium channels in rat striatal synaptosomesQ48948371
Chronic alcohol reduces calcium signaling elicited by glutamate receptor stimulation in developing cerebellar neuronsQ48960408
The role of group I mGlu receptors in the expression of ethanol-induced conditioned place preference and ethanol withdrawal seizures in rats.Q51852939
Ethanol inhibits development of dendrites and synapses in rat hippocampal pyramidal neuron cultures.Q52538923
Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cellsQ57983099
P433issue2
P921main subjectneurotoxicityQ3338704
toxic encephalopathyQ7830379
P304page(s)128-135
P577publication date2015-08-12
P1433published inAlcohol and AlcoholismQ15751935
P1476titleGET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons
P478volume51

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cites work (P2860)
Q47753586A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers
Q47555227Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET 73 with alcohol: A translational study in rats and humans.
Q52318135In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5.

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