scholarly article | Q13442814 |
P356 | DOI | 10.1093/ALCALC/AGV094 |
P698 | PubMed publication ID | 26271115 |
P50 | author | Luca Ferraro | Q38548471 |
P2093 | author name string | Sergio Tanganelli | |
Tiziana Antonelli | |||
Sarah Beggiato | |||
Antonella Loche | |||
Andrea C Borelli | |||
Maria C Tomasini | |||
Roberto Cacciaglia | |||
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Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73 | Q35755149 | ||
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The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties | Q38122179 | ||
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Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary culture. | Q42911706 | ||
The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors | Q44666716 | ||
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Neuroprotective effects of NMDA and group I metabotropic glutamate receptor antagonists against neurodegeneration induced by homocysteine in rat hippocampus: in vivo study. | Q48093115 | ||
GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor. | Q48093143 | ||
Effects of ethanol on excitatory and inhibitory synaptic transmission in rat cortical neurons | Q48317747 | ||
Ethanol induces MAP2 changes in organotypic hippocampal slice cultures | Q48341464 | ||
Long-term alcohol self-administration and alcohol withdrawal differentially modulate microtubule-associated protein 2 (MAP2) gene expression in the rat brain | Q48351482 | ||
GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. | Q48646646 | ||
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P433 | issue | 2 | |
P921 | main subject | neurotoxicity | Q3338704 |
toxic encephalopathy | Q7830379 | ||
P304 | page(s) | 128-135 | |
P577 | publication date | 2015-08-12 | |
P1433 | published in | Alcohol and Alcoholism | Q15751935 |
P1476 | title | GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons | |
P478 | volume | 51 |
Q47753586 | A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers |
Q47555227 | Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET 73 with alcohol: A translational study in rats and humans. |
Q52318135 | In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5. |
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