Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling

scientific article published on 21 December 2005

Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M507622200
P698PubMed publication ID16371368

P2093author name stringJing Chen
Cheng-Kui Qu
Wen-Mei Yu
Kevin D Bunting
Hanako Daino
P2860cites workMutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndromeQ24291893
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2Q24314461
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesisQ24316448
Crystal structure of the tyrosine phosphatase SHP-2Q27748898
Shc associates with the IL-3 receptor β subunit, SHIP and Gab2 following IL-3 stimulationQ28137857
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signalingQ28182148
Jak2 is essential for signaling through a variety of cytokine receptorsQ28270987
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemiaQ28298677
Nf1 and Gmcsf interact in myeloid leukemogenesisQ28507018
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutationQ28594140
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayQ28608965
Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptorQ28609037
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damageQ29619360
Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell developmentQ31835063
Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptorQ33661908
Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cellsQ33781066
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiledQ33941375
Combinatorial control of the specificity of protein tyrosine phosphatasesQ34180660
Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular responseQ34991820
Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factorQ35847470
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cellsQ35847802
Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressorQ35964121
Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokinesQ36400929
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell developmentQ36572223
Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signalingQ40637759
Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapyQ40921921
Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.Q41743522
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemiaQ44419404
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesisQ44673842
Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.Q44760563
A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survivalQ44872938
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)5426-5434
P577publication date2005-12-21
P1433published inJournal of Biological ChemistryQ867727
P1476titleEffects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling
P478volume281