| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1001050799 |
| P356 | DOI | 10.1038/SJ.ONC.1206846 |
| P698 | PubMed publication ID | 12955078 |
| P5875 | ResearchGate publication ID | 10583485 |
| P2093 | author name string | Cheng-Kui Qu | |
| Robert G Hawley | |||
| Teresa S Hawley | |||
| Wen-Mei Yu | |||
| P2860 | cites work | Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis | Q24316448 |
| Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation | Q24522542 | ||
| Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility | Q24554511 | ||
| Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras | Q24564495 | ||
| Shc associates with the IL-3 receptor β subunit, SHIP and Gab2 following IL-3 stimulation | Q28137857 | ||
| Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes | Q28142403 | ||
| Engagement of Gab1 and Gab2 in erythropoietin signaling | Q28142601 | ||
| Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration | Q28207410 | ||
| Jak2 is essential for signaling through a variety of cytokine receptors | Q28270987 | ||
| p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells | Q28295241 | ||
| New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway | Q28608965 | ||
| Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor | Q28609037 | ||
| SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates | Q28609045 | ||
| Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation | Q28609054 | ||
| Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response | Q30164884 | ||
| Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development | Q31835063 | ||
| Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor | Q33661908 | ||
| Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells | Q33781066 | ||
| Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. | Q33886525 | ||
| IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled | Q33941375 | ||
| Combinatorial control of the specificity of protein tyrosine phosphatases | Q34180660 | ||
| Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response | Q34991820 | ||
| Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals | Q35554092 | ||
| A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development | Q36572223 | ||
| A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase | Q36643931 | ||
| Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis | Q36827728 | ||
| Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor | Q39574213 | ||
| Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. | Q39674852 | ||
| Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression | Q40018398 | ||
| Immortalization of yolk sac-derived precursor cells | Q40695020 | ||
| The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases | Q41056278 | ||
| JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells. | Q41197797 | ||
| Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation | Q41344702 | ||
| Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation | Q41566187 | ||
| The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells | Q42971603 | ||
| Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance. | Q51560565 | ||
| The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development | Q72553432 | ||
| Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant | Q73379065 | ||
| Signaling by the cytokine receptor superfamily | Q77934807 | ||
| P433 | issue | 38 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 5995-6004 | |
| P577 | publication date | 2003-09-01 | |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling | |
| P478 | volume | 22 |
| Q35164251 | A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells |
| Q34310556 | A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells |
| Q44872938 | A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival |
| Q36905741 | A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma |
| Q34722748 | Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder |
| Q39724484 | Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability |
| Q42787003 | Complex systems biology approach to understanding coordination of JAK-STAT signaling |
| Q46863352 | Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling |
| Q54313329 | Expression and significance of SHP-2 in human papillomavirus infected cervical cancer. |
| Q35847802 | Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells |
| Q24646920 | G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia |
| Q39998279 | Gab adapter proteins as therapeutic targets for hematologic disease |
| Q52646137 | Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner. |
| Q38083005 | Helicobacter pylori CagA: a critical destroyer of the gastric epithelial barrier |
| Q37480567 | Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1. |
| Q44457397 | Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells |
| Q34155125 | Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11). |
| Q37104928 | Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay |
| Q37150984 | Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence |
| Q33774488 | Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations |
| Q34283145 | Interleukin-3 receptor in acute leukemia |
| Q35237519 | Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells |
| Q34493945 | Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints |
| Q41772799 | Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| Q35616065 | PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase |
| Q35101627 | Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis |
| Q37616725 | Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice. |
| Q30525672 | Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability |
| Q28646447 | Protein tyrosine phosphatases in the JAK/STAT pathway |
| Q46968616 | Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia |
| Q33893558 | Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP |
| Q35615838 | SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl |
| Q39298327 | SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon-β production |
| Q46784050 | SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively |
| Q37186707 | SHP-2 tyrosine phosphatase in human diseases. |
| Q90103848 | Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages |
| Q34245628 | Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer |
| Q40039203 | Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates |
| Q93239307 | Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2 |
| Q37078692 | TLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors |
| Q37161507 | Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies |
| Q38261370 | Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention |
| Q85769864 | The DN2 Myeloid-T (DN2mt) Progenitor is a Target Cell for Leukemic Transformation by the TLX1 Oncogene |
| Q40202131 | The Helicobacter pylori virulence factor CagA promotes Erk1/2-mediated Bad phosphorylation in lymphocytes: a mechanism of CagA-inhibited lymphocyte apoptosis |
| Q36836455 | The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury |
| Q40165041 | The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes. |
| Q28246907 | You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling |
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