| scholarly article | Q13442814 |
| P2093 | author name string | B G Neel | |
| C T Walsh | |||
| S Sugimoto | |||
| A M Bennett | |||
| T L Tang | |||
| P2860 | cites work | GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit | Q24292767 |
| Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation | Q24293143 | ||
| Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1 | Q24304774 | ||
| Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor | Q24310840 | ||
| Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation | Q24314456 | ||
| Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells | Q24324441 | ||
| The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling | Q24336226 | ||
| Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew | Q24563125 | ||
| Signal transduction by receptors with tyrosine kinase activity | Q27860624 | ||
| An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro | Q28267609 | ||
| Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling | Q28268458 | ||
| The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp | Q28269747 | ||
| Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal | Q28297924 | ||
| The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 | Q28511655 | ||
| Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1 | Q28645716 | ||
| Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction | Q29615257 | ||
| Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor | Q29616395 | ||
| Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation | Q29616396 | ||
| Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras | Q29617087 | ||
| Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases | Q29618331 | ||
| Detection and quantification of phosphotyrosine in proteins | Q29620010 | ||
| SH2 and SH3 domains: from structure to function | Q29620259 | ||
| A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. | Q30195071 | ||
| Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation | Q34166097 | ||
| Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit | Q34306139 | ||
| A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains | Q36160627 | ||
| A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase | Q36643931 | ||
| Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively | Q36658598 | ||
| The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor | Q37537225 | ||
| ras GTPase activating protein: signal transmitter and signal terminator | Q38264105 | ||
| SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases | Q41566173 | ||
| Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation | Q41566187 | ||
| Association between the PDGF receptor and members of the src family of tyrosine kinases | Q41725198 | ||
| corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso | Q42612628 | ||
| Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain | Q42808327 | ||
| Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. | Q42808857 | ||
| Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src | Q44049774 | ||
| Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation | Q44763188 | ||
| Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. | Q52545888 | ||
| Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. | Q54649549 | ||
| Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal | Q70501370 | ||
| P433 | issue | 15 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 7335-9 | |
| P577 | publication date | 1994-07-19 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras | |
| P478 | volume | 91 |
| Q24310969 | A THEMIS:SHP1 complex promotes T-cell survival |
| Q36572223 | A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development |
| Q24336010 | A family of proteins that inhibit signalling through tyrosine kinase receptors |
| Q30176126 | A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes |
| Q37387072 | A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation |
| Q30357327 | Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. |
| Q41181055 | Activating mechanism of CNTF and related cytokines |
| Q34722748 | Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder |
| Q24324749 | Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule |
| Q24304168 | Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction |
| Q41344702 | Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation |
| Q40728126 | Analysis of IL-6-mediated growth control of myeloma cells using a gp130 chimeric receptor approach |
| Q30497716 | Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton |
| Q36833243 | Analyzing protein tyrosine phosphatases by phosphotyrosine analog integration |
| Q57630587 | Angiotensin II Stimulates Tyrosine Phosphorylation and Activation of Insulin Receptor Substrate 1 and Protein-tyrosine Phosphatase 1D in Vascular Smooth Muscle Cells |
| Q30176752 | Association between receptor protein-tyrosine phosphatase RPTPalpha and the Grb2 adaptor. Dual Src homology (SH) 2/SH3 domain requirement and functional consequences |
| Q28297366 | Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1C |
| Q26752544 | Biochemical and Functional Insights into the Integrated Regulation of Innate Immune Cell Responses by Teleost Leukocyte Immune-Type Receptors |
| Q30193377 | Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila. |
| Q45113910 | Biology of the interleukin-2 receptor |
| Q73084781 | Both SH2 domains are involved in interaction of SHP-1 with the epidermal growth factor receptor but cannot confer receptor-directed activity to SHP-1/SHP-2 chimera |
| Q33965534 | Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors |
| Q28138409 | Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons |
| Q40637759 | Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling |
| Q57364608 | Chapter 11 Interaction of pulmonary endothelial cells with blood elements |
| Q71763037 | Characterization of a 115-kDa protein that binds to SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in Chinese hamster ovary cells |
| Q73427529 | Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3'-kinase in myeloid cells |
| Q24315098 | Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2 |
| Q28266811 | Characterization of the signaling capacities of the novel gp130-like cytokine receptor |
| Q28235378 | Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors |
| Q33637565 | Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphatase |
| Q28513246 | Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses |
| Q27765696 | Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1 |
| Q47846589 | DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels |
| Q46765571 | Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling |
| Q39574213 | Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor |
| Q42826938 | Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation |
| Q28302000 | Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase |
| Q28289488 | Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor |
| Q40963041 | Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways |
| Q27679810 | Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains |
| Q43510196 | Divergent roles of SHP-2 in ERK activation by leptin receptors |
| Q28678768 | Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu |
| Q42003906 | Dopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2. |
| Q42628720 | Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. |
| Q28284486 | Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2 |
| Q54313329 | Expression and significance of SHP-2 in human papillomavirus infected cervical cancer. |
| Q51560565 | Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance. |
| Q41197808 | Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3'-kinase activity via modulation of phosphorylation of insulin receptor substrate-1. |
| Q28211519 | Fibroblast growth factor signaling in Caenorhabditis elegans |
| Q77787738 | Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal growth factor or insulin-like growth factor-I in human skin fibroblasts |
| Q35847802 | Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells |
| Q47724155 | Functional involvement of PTP-U2L in apoptosis subsequent to terminal differentiation of monoblastoid leukemia cells |
| Q36057452 | Functions of Shp2 in cancer |
| Q39575287 | Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase |
| Q36086815 | Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells. |
| Q91737749 | Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway |
| Q52646137 | Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner. |
| Q36551546 | Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies |
| Q41213110 | Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signaling. |
| Q64038852 | Growth effects of regulatory peptides and intracellular signaling routes in human pancreatic cancer cell lines |
| Q42833810 | Growth factors stimulate tyrosine dephosphorylation of p75 and its dissociation from the SH2 domain of Grb2. |
| Q42831119 | Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association |
| Q30828692 | HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity. |
| Q33292148 | Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation |
| Q36648071 | Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function |
| Q29616397 | Hyperactive Ras in developmental disorders and cancer |
| Q38291369 | Identification of a putative Syp substrate, the PDGF beta receptor |
| Q33917132 | Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750 |
| Q42825844 | Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin |
| Q28646549 | Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules |
| Q38361170 | Independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor. |
| Q37150984 | Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence |
| Q39026381 | Induction of phagocytosis and intracellular signaling by an inhibitory channel catfish leukocyte immune-type receptor: evidence for immunoregulatory receptor functional plasticity in teleosts. |
| Q24294717 | Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2 |
| Q28235496 | Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2 |
| Q28287538 | Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways |
| Q42833012 | Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling |
| Q37469169 | Low-dose dasatinib rescues cardiac function in Noonan syndrome |
| Q49905672 | MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development. |
| Q30175408 | Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins |
| Q38295765 | Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation |
| Q37169498 | Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation |
| Q33962208 | Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity |
| Q38167994 | Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling |
| Q58483487 | Multiple Signals Mediate Proliferation, Differentiation, and Survival from the Granulocyte Colony-stimulating Factor Receptor in Myeloid 32D Cells |
| Q40018398 | Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression |
| Q38337309 | Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew |
| Q34284265 | Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation |
| Q35237519 | Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells |
| Q28140259 | Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor |
| Q58804985 | Off-target inhibition by active site-targeting SHP2 inhibitors |
| Q52567718 | Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. |
| Q35842771 | PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation. |
| Q36025665 | PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots? |
| Q36564274 | Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation |
| Q37611336 | Physiological signaling specificity by protein tyrosine phosphatases |
| Q41687870 | Platelet-derived growth factor in human brain tumors |
| Q36563209 | Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity |
| Q33329496 | Prediction of phosphotyrosine signaling networks using a scoring matrix-assisted ligand identification approach |
| Q73304067 | Predominant expression of the src homology 2-containing tyrosine phosphatase protein SHP2 in vascular smooth muscle cells |
| Q35101627 | Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis |
| Q27860694 | Protein modules and signalling networks |
| Q34779578 | Protein phosphorylation by semisynthesis: from paper to practice |
| Q24323764 | Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor |
| Q30525672 | Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability |
| Q71475516 | Protein tyrosine phosphatases and the control of cellular signaling responses |
| Q41099677 | Protein tyrosine phosphatases in signaling |
| Q37094065 | Protein tyrosine phosphatases: regulatory mechanisms |
| Q71743301 | Protein-tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation |
| Q40988710 | Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. |
| Q96302844 | RAS-targeted therapies: is the undruggable drugged? |
| Q24321244 | Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting |
| Q41069980 | Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo |
| Q24533497 | Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity |
| Q38132066 | Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development |
| Q38031978 | Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity |
| Q30176913 | Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1 |
| Q43847030 | Regulation of insulin-like growth factor I receptor dephosphorylation by SHPS-1 and the tyrosine phosphatase SHP-2. |
| Q30304402 | Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2. |
| Q28510962 | Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism |
| Q37144056 | Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives |
| Q43737894 | Requirement of protein tyrosine phosphatase SHP2 for NO-stimulated vascular smooth muscle cell motility |
| Q36549069 | Role of Aspergillus fumigatus in Triggering Protease-Activated Receptor-2 in Airway Epithelial Cells and Skewing the Cells toward a T-helper 2 Bias. |
| Q28589835 | Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation |
| Q26745112 | Role of Protein Phosphorylation and Tyrosine Phosphatases in the Adrenal Regulation of Steroid Synthesis and Mitochondrial Function |
| Q39674676 | Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts |
| Q38165106 | Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance |
| Q34991820 | Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response |
| Q30436912 | SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels |
| Q74129083 | SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of phosphatidylinositol 3-kinase |
| Q77954368 | SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis |
| Q28512136 | SHP-2 is a novel target of Abl kinases during cell proliferation |
| Q28592459 | SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons |
| Q46784050 | SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively |
| Q37186707 | SHP-2 tyrosine phosphatase in human diseases. |
| Q28609045 | SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates |
| Q64234731 | SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors |
| Q90473839 | SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models |
| Q53080575 | SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors. |
| Q99565940 | SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway |
| Q39703419 | SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration. |
| Q90012532 | Selective Regulation of Cytoskeletal Dynamics and Filopodia Formation by Teleost Leukocyte Immune-Type Receptors Differentially Contributes to Target Capture During the Phagocytic Process |
| Q73618049 | Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide |
| Q41751641 | Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt. |
| Q44068703 | Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1. |
| Q37690945 | Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells |
| Q46627912 | Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1. |
| Q34307028 | Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty |
| Q58173667 | Signal TransductionThrough Cytokine Receptors |
| Q28609164 | Signal transduction via platelet-derived growth factor receptors |
| Q24291843 | Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling |
| Q34087763 | Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2. |
| Q40737797 | Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation. |
| Q31088288 | Specificity and affinity motifs for Grb2 SH2-ligand interactions |
| Q41973102 | Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. |
| Q40653225 | Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP-2) Can Play a Direct Role in the Inhibitory Function of Killer Cell Ig-Like Receptors in Human NK Cells |
| Q36380535 | Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival |
| Q39631199 | Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction |
| Q35781235 | Structure-based kinetic models of modular signaling protein function: focus on Shp2. |
| Q30167815 | The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction |
| Q36685093 | The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3'-kinase in NIH 3T3 cells |
| Q36551325 | The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1 |
| Q51766789 | The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects. |
| Q28066941 | The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation |
| Q30175786 | The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism |
| Q40676965 | The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2. |
| Q42811932 | The low Mr phosphotyrosine protein phosphatase behaves differently when phosphorylated at Tyr131 or Tyr132 by Src kinase |
| Q33756968 | The next wave: protein tyrosine phosphatases enter T cell antigen receptor signalling |
| Q37405181 | The phosphatase SHP2 regulates the spacing effect for long-term memory induction |
| Q41347048 | The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors |
| Q28257190 | The platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs |
| Q48534010 | The protein tyrosine phosphatase SHP-2 is expressed in glial and neuronal progenitor cells, postmitotic neurons and reactive astrocytes |
| Q28637904 | The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression |
| Q28566441 | The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31) |
| Q28609032 | The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells |
| Q33577586 | The role of Src homology 2 containing protein tyrosine phosphatase 2 in vascular smooth muscle cell migration and proliferation |
| Q40782327 | The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes |
| Q28144584 | The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2 |
| Q33605698 | The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase |
| Q40165041 | The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes. |
| Q39016533 | The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V. |
| Q38327407 | The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2. |
| Q73047381 | Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets |
| Q24554732 | Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor |
| Q41153893 | Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. |
| Q37624851 | Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. |
| Q60908203 | Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation |
| Q28118868 | Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors |
| Q41251781 | What's new in ras genes? Physiological role of ras genes in signal transduction and significance of ras gene activation in tumorigenesis |
| Q30192884 | c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts |
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