Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner. (scientific article published on 20 March 2018)

Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling

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Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

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Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis

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Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis.

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Housing, husbandry and handling of rodents for behavioral experiments.

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Progressive hydrocephalus in two members of a family with autosomal dominant Noonan phenotype

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Progressive hydrocephalus in Noonan syndrome

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Reaching and grasping phenotypes in the mouse (Mus musculus): a characterization of inbred strains and mutant lines

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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Noonan syndrome

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Crystal structure of the tyrosine phosphatase SHP-2

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

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PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

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Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

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Protein tyrosine phosphatases in the JAK/STAT pathway

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When cilia go bad: cilia defects and ciliopathies

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Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

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Hydrocephalus in children

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Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome

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Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

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IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells

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The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

Q34627120

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

Q34714329

Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

Q35237519

Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice

Q35641557

PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?

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Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality

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Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons

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A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

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Noonan's syndrome with hydrocephalus, hindbrain herniation, and upper cervical intracord cyst

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Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies

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Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

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The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon

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Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

Q37653117

Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

Q40018398

Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb.

Q40187444

Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling

Q40637759

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

Q41743522

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

Q42480603

Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

Q42591567

PTPN11 mutations in LEOPARD syndrome

Q43056955

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

Q44419404

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

Q44673842

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

Q44775999

PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group

Q45073102

Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling

Q46863352

P433

issue

522

P921

main subject

hydrocephalus

Q193003