| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Benjamin G Neel | |
| Haihua Gu | |||
| Lily Pao | |||
| P2860 | cites work | Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation | Q22011187 |
| Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton | Q22253423 | ||
| Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation | Q22254014 | ||
| Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2 | Q24291169 | ||
| Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling | Q24291843 | ||
| Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome | Q24291893 | ||
| CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion | Q24312667 | ||
| sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways | Q24336220 | ||
| The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis | Q24550897 | ||
| Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility | Q24554511 | ||
| Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways | Q24630500 | ||
| Essential role of Gab1 for signaling by the c-Met receptor in vivo | Q24685688 | ||
| Crystal structure of the tyrosine phosphatase SHP-2 | Q27748898 | ||
| Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1 | Q27765696 | ||
| Cell signaling by receptor tyrosine kinases | Q27860474 | ||
| Signaling through scaffold, anchoring, and adaptor proteins | Q28131792 | ||
| Role of CD47 as a marker of self on red blood cells | Q28138449 | ||
| CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2 | Q28140132 | ||
| SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130 | Q28142716 | ||
| SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages | Q28143425 | ||
| Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases | Q28143793 | ||
| Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals | Q28236222 | ||
| Integrin-associated protein is a ligand for the P84 neural adhesion molecule | Q28292745 | ||
| Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation | Q28505657 | ||
| SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility | Q28508471 | ||
| Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses | Q28513246 | ||
| Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation | Q28589835 | ||
| Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation | Q28609054 | ||
| Critical role for Gab2 in transformation by BCR/ABL | Q28610046 | ||
| PTPN11 (Protein-Tyrosine Phosphatase, Nonreceptor-Type 11) Mutations in Seven Japanese Patients with Noonan Syndrome | Q29395225 | ||
| Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo | Q29615579 | ||
| The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction | Q30167815 | ||
| Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. | Q30453611 | ||
| Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils | Q43851620 | ||
| In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling | Q47070546 | ||
| Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn. | Q48203636 | ||
| Prevalence of priapism in children and adolescents with sickle cell anemia | Q48736758 | ||
| The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. | Q52169619 | ||
| The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. | Q52208956 | ||
| Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. | Q52567718 | ||
| The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. | Q54464762 | ||
| Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs | Q57039952 | ||
| Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap | Q57185247 | ||
| Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase | Q58483709 | ||
| Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice | Q73163205 | ||
| Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant | Q73379065 | ||
| Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts | Q77785363 | ||
| Determination of the binding specificity of the SH2 domains of protein tyrosine phosphatase SHP-1 through the screening of a combinatorial phosphotyrosyl peptide library | Q30951598 | ||
| SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein | Q33292154 | ||
| The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase | Q33605698 | ||
| Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells | Q33781066 | ||
| Shp-2 tyrosine phosphatase: signaling one cell or many | Q33783500 | ||
| Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase | Q33891348 | ||
| Genetic heterogeneity in Noonan syndrome: evidence for an autosomal recessive form | Q33917470 | ||
| Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps | Q33961297 | ||
| Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity | Q33962208 | ||
| Structural and evolutionary relationships among protein tyrosine phosphatase domains | Q34012560 | ||
| Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling | Q34038099 | ||
| Immune inhibitory receptors | Q34054933 | ||
| Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway | Q34156402 | ||
| PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity | Q34522913 | ||
| Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. | Q34714329 | ||
| The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development | Q35191574 | ||
| Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 | Q35777741 | ||
| CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis | Q36369098 | ||
| Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. | Q36375906 | ||
| Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor | Q36376086 | ||
| Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2. | Q36451457 | ||
| Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation | Q36667325 | ||
| Identification of a putative Syp substrate, the PDGF beta receptor | Q38291369 | ||
| Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew | Q38337309 | ||
| Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction | Q39631199 | ||
| The ras gene family and human carcinogenesis | Q39638098 | ||
| Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. | Q39674852 | ||
| The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation | Q39698949 | ||
| Grb2 is a key mediator of helicobacter pylori CagA protein activities | Q40691954 | ||
| The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer | Q40715301 | ||
| A bipartite NLS at the SHP-1 C-terminus mediates cytokine-induced SHP-1 nuclear localization in cell growth control | Q40734721 | ||
| The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors | Q40775807 | ||
| The protein tyrosine phosphatase Shp-2 regulates RhoA activity | Q40837843 | ||
| An immunoreceptor tyrosine-based inhibitory motif, with serine at site Y-2, binds SH2-domain-containing phosphatases | Q40903415 | ||
| Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion | Q41018719 | ||
| Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases | Q41040319 | ||
| The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases | Q41056278 | ||
| Genetic analysis of protein tyrosine phosphatases | Q41732769 | ||
| Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2. | Q41743522 | ||
| A functional nuclear localization sequence in the C-terminal domain of SHP-1. | Q43589200 | ||
| Coupling of the TCR to integrin activation by Slap-130/Fyb. | Q43744923 | ||
| Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. | Q43847045 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 284-93 | |
| P577 | publication date | 2003-06-01 | |
| P1433 | published in | Trends in Biochemical Sciences | Q1565711 |
| P1476 | title | The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling | |
| P478 | volume | 28 |
| Q46634497 | 'Fine tuning' TLR signaling |
| Q38337563 | A G-quadruplex aptamer inhibits the phosphatase activity of oncogenic protein Shp2 in vitro |
| Q42595016 | A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. |
| Q42732055 | A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease |
| Q33418622 | A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase |
| Q35164251 | A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells |
| Q34661632 | A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. |
| Q34310556 | A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells |
| Q50709731 | A new mutation in the C-SH2 domain of PTPN11 causes Noonan syndrome with multiple giant cell lesions. |
| Q35802247 | A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. |
| Q53155404 | A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development. |
| Q46486596 | A novel mutation in the PTPN11 gene in a patient with Noonan syndrome and rapidly progressive hypertrophic cardiomyopathy |
| Q34496532 | A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor |
| Q35036951 | A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling. |
| Q40337530 | A role for the scaffolding adapter GAB2 in breast cancer |
| Q28546771 | A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions |
| Q38125933 | A star is born: new insights into the mechanism of astrogenesis |
| Q33335137 | A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor |
| Q36905741 | A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma |
| Q90591189 | ADAM proteases: Emerging role and targeting of the non-catalytic domains |
| Q36956438 | Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation |
| Q91658018 | Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas |
| Q36707206 | Activating and inhibitory functions of DAP12. |
| Q64911619 | Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor. |
| Q35611046 | Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis |
| Q34105208 | Alterations of cell cycle control proteins SHP‑1/2, p16, CDK4 and cyclin D1 in radioresistant nasopharyngeal carcinoma cells |
| Q24302141 | An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway |
| Q33196000 | An oriented peptide array library (OPAL) strategy to study protein-protein interactions |
| Q36702801 | An unexpected new role of mutant Ras: perturbation of human embryonic development |
| Q33292197 | Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein. |
| Q42957138 | Analysis of cell type-specific responses mediated by the type IV secretion system of Helicobacter pylori |
| Q33531871 | Analysis of translocation of the CagA protein and induction of a scattering phenotype in AGS cells infected with Helicobacter pylori |
| Q30583338 | Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade. |
| Q35200418 | Anesthetic considerations and difficult airway management in a case of Noonan syndrome |
| Q36042466 | Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1. |
| Q36082986 | Annexin II binds to SHP2 and this interaction is regulated by HSP70 levels |
| Q42637452 | Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2. |
| Q36648611 | Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling |
| Q80689024 | Are ECG abnormalities in Noonan syndrome characteristic for the syndrome? |
| Q33955193 | Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation |
| Q34128696 | Association of Shp2 with Phosphorylated IL-22R1 is Required for Interleukin-22-induced MAP Kinase Activation |
| Q33480292 | Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese |
| Q52887160 | Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains. |
| Q39750624 | Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth |
| Q35815528 | Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors |
| Q34116796 | Biochemical signaling of PD-1 on T cells and its functional implications |
| Q89747847 | Bioevaluation of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with dihexadecyl phosphate (DHP) |
| Q40200987 | Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins |
| Q37947515 | Bleeding disorders in Noonan syndrome |
| Q41963150 | CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling |
| Q56891117 | Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity |
| Q30479002 | Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response |
| Q42704531 | Causal role of Helicobacter pylori infection in gastric cancer |
| Q49679681 | Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies |
| Q36780168 | Chronic inflammation: a failure of resolution? |
| Q43274847 | CoA Synthase is phosphorylated on tyrosines in mammalian cells, interacts with and is dephosphorylated by Shp2PTP. |
| Q30442674 | Comprehensive behavioral analysis of cluster of differentiation 47 knockout mice |
| Q41492239 | Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection |
| Q35567412 | Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation |
| Q90092671 | Connecting the dots between SHP2 and glutamate receptors |
| Q30479691 | Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome |
| Q33637565 | Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphatase |
| Q28575761 | Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells |
| Q46220127 | Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia |
| Q38709527 | Cot kinase plays a critical role in Helicobacter pylori-induced IL-8 expression. |
| Q41843881 | Counteracting effects operating on Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome |
| Q55517431 | Co‐occurrence of hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia in a neonate with Noonan syndrome, leading to premature death. |
| Q33568776 | Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation |
| Q34713949 | Critical role of Shp2 in tumor growth involving regulation of c-Myc |
| Q27302315 | Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment |
| Q35195305 | Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis |
| Q34859485 | Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis |
| Q37371235 | Deletion in a (T)8 microsatellite abrogates expression regulation by 3'-UTR. |
| Q38605378 | Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways |
| Q37033644 | Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death |
| Q96304844 | Demonstration of Binding Induced Structural Plasticity in a SH2 Domain |
| Q36579837 | Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. |
| Q37137867 | Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines |
| Q38000471 | Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase |
| Q42131816 | Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations |
| Q36010991 | Direct Chemical Activation of a Rationally Engineered Signaling Enzyme |
| Q36910125 | Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions |
| Q36340315 | Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2. |
| Q34440570 | Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms |
| Q37705054 | Distinct and overlapping functions of ptpn11 genes in Zebrafish development |
| Q24303794 | Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells |
| Q36731891 | Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice |
| Q42480603 | Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes |
| Q33979110 | Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes |
| Q24540529 | Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease |
| Q42003906 | Dopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2. |
| Q37500352 | Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B. |
| Q39100773 | Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. |
| Q37712106 | Dynamic Expansion and Contraction of cagA Copy Number in Helicobacter pylori Impact Development of Gastric Disease. |
| Q39458568 | Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion |
| Q28271778 | ERK1/2 is a negative regulator of homeodomain protein Arix/Phox2a |
| Q48451148 | ERKquake in Noonan syndrome: one step closer to personalized medicine |
| Q44709195 | Effective dephosphorylation of Src substrates by SHP-1. |
| Q46863352 | Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling |
| Q36000046 | Elevated Ca2+ transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines. |
| Q38965929 | Elucidation of epithelial-mesenchymal transition-related pathways in a triple-negative breast cancer cell line model by multi-omics interactome analysis. |
| Q28594117 | Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development |
| Q34102154 | Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis |
| Q41536412 | Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions |
| Q92301856 | Enterohemorrhagic Escherichia coli Tir inhibits TAK1 activation and mediates immune evasion |
| Q36866432 | Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2. |
| Q33627481 | Epidemiological link between gastric disease and polymorphisms in VacA and CagA. |
| Q46094753 | Epigallocatechin-3-gallate induces apoptosis in acute promyelocytic leukemia cells via a SHP-1-p38α MAPK-Bax cascade |
| Q47954024 | Ethanol Iris tenuifolia extract reduces brain damage in a mouse model of cerebral ischaemia |
| Q92147972 | Excitatory neuron-specific SHP2-ERK signaling network regulates synaptic plasticity and memory |
| Q37004824 | Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations |
| Q35697362 | Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors |
| Q40180313 | Expression and prognosis value of SHP2 in patients with pancreatic ductal adenocarcinoma |
| Q54313329 | Expression and significance of SHP-2 in human papillomavirus infected cervical cancer. |
| Q40485872 | FLT3/ITD mutation signaling includes suppression of SHP-1. |
| Q35730802 | Feedback regulation of lymphocyte signalling |
| Q40725761 | Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. |
| Q21245511 | Function, regulation and pathological roles of the Gab/DOS docking proteins |
| Q36100102 | Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia |
| Q35847802 | Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells |
| Q37459752 | G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation |
| Q36198637 | G-quadruplex-based aptamers against protein targets in therapy and diagnostics. |
| Q24337649 | GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling |
| Q30160040 | GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells |
| Q39998279 | Gab adapter proteins as therapeutic targets for hematologic disease |
| Q43200145 | Gab docking proteins in cardiovascular disease, cancer, and inflammation |
| Q44770020 | Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor |
| Q28590764 | Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility |
| Q91737749 | Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway |
| Q47955988 | Gain-of-function mutation in PTPN11 in histiocytic sarcomas of Bernese Mountain Dogs. |
| Q52646137 | Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner. |
| Q30477015 | Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling |
| Q36808017 | Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents |
| Q38435146 | Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia. |
| Q36925323 | Genetic approaches for changing the heart and dissecting complex syndromes |
| Q36094712 | Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF. |
| Q33509913 | Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study |
| Q37821283 | Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions |
| Q28297024 | Germline KRAS mutations cause Noonan syndrome |
| Q28276979 | Germline gain-of-function mutations in SOS1 cause Noonan syndrome |
| Q24293473 | Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype |
| Q52314492 | Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects. |
| Q48880415 | Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB. |
| Q38190020 | H. pylori infection, inflammation and gastric cancer |
| Q35194936 | HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability |
| Q37230001 | Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine |
| Q28287897 | Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis |
| Q83448743 | Helicobacter pylori and gastric carcinogenesis |
| Q35192226 | Helicobacter pylori homB, but not cagA, is associated with gastric cancer in Iran |
| Q49199872 | Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway |
| Q36970188 | Hematopoietic cytokine receptor signaling |
| Q36049875 | Hepatic Src homology phosphatase 2 regulates energy balance in mice. |
| Q37238556 | Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation |
| Q33727656 | High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo. |
| Q36497083 | High-throughput mutational analysis of the human cancer genome |
| Q46402382 | Hodgkin's lymphoma in a patient with Noonan syndrome with germ-line PTPN11 mutations |
| Q30160334 | Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes |
| Q33314672 | Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction |
| Q29616397 | Hyperactive Ras in developmental disorders and cancer |
| Q42504354 | Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain |
| Q84790850 | IDO: more than an enzyme |
| Q34155125 | Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11). |
| Q37104928 | Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay |
| Q38774879 | Immunoreceptors on neutrophils |
| Q35661008 | Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones |
| Q64064817 | Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis |
| Q40650977 | Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking |
| Q48262635 | Increased Src Family Kinase Activity Disrupts Excitatory Synaptic Transmission and Impairs Remote Fear Memory in Forebrain Shp2-Deficient Mice. |
| Q28588016 | Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells |
| Q36937153 | Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger |
| Q36951816 | Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. |
| Q24299272 | Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs |
| Q34005613 | Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112. |
| Q39372797 | Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1/Tie-2 signaling in diabetes |
| Q92965686 | Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers |
| Q46930160 | Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo. |
| Q33357659 | Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds |
| Q96640282 | Insulin receptor endocytosis in the pathophysiology of insulin resistance |
| Q34627656 | Integrating signals from RTKs to ERK/MAPK. |
| Q90408578 | Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation |
| Q35676632 | Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway |
| Q37578039 | Intercellular adhesion molecule 1: recent findings and new concepts involved in mammalian spermatogenesis |
| Q24535045 | Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes |
| Q40091012 | Intrinsic signaling functions of the beta4 integrin intracellular domain |
| Q24318475 | Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics |
| Q54457318 | Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase. |
| Q35804427 | Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. |
| Q54592678 | Is Raf1 a nexus for cardiac hypertrophic signaling in human disease? |
| Q40020065 | Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors |
| Q35029942 | Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool |
| Q41880278 | LEOPARD Syndrome: Clinical Features and Gene Mutations |
| Q21144548 | Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif |
| Q21202917 | Leopard syndrome |
| Q46862466 | Lethal proliferation of erythroid precursors in a neonate with a germline PTPN11 mutation |
| Q28082576 | Leukemia inhibitory factor (LIF) |
| Q46794787 | Levodopa/Benserazide Loaded Microspheres Alleviate L-dopa Induced Dyskinesia through Preventing the Over-Expression of D1R/Shp-2/ERK1/2 Signaling Pathway in a Rat Model of Parkinson's Disease |
| Q37333631 | Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA. |
| Q38809055 | Loss of Ptpn11 (Shp2) drives satellite cells into quiescence |
| Q37211936 | Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis |
| Q41980507 | Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration |
| Q85563932 | Low expression of SHP-2 is associated with less favorable prostate cancer outcomes |
| Q38185972 | Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity. |
| Q34853182 | MAP3Ks as central regulators of cell fate during development |
| Q41647387 | MEK Is a Key Regulator of Gliogenesis in the Developing Brain. |
| Q33828434 | MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling. |
| Q36473553 | Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. |
| Q58097742 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2 |
| Q36047171 | Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia |
| Q36272597 | Mechanisms of PECAM-1-mediated cytoprotection and implications for cancer cell survival |
| Q90437101 | Mechanistic insights explain the transforming potential of the T507K substitution in the protein tyrosine phosphatase SHP2 |
| Q35879519 | Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome |
| Q44314344 | Meta-analysis of the association between PTPN11 G/A polymorphism at intron 3 with risk of gastric atrophy among East Asians |
| Q36487056 | MicroRNAs and toll-like receptor/interleukin-1 receptor signaling |
| Q24293054 | Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling |
| Q43273693 | Modulation of SHP-1 phosphatase activity by monovalent and bivalent SH2 phosphopeptide ligands |
| Q39020269 | Modulation of VEGF receptor 2 signaling by protein phosphatases |
| Q42800448 | Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3. |
| Q36596151 | Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. |
| Q27684353 | Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations |
| Q50587974 | Molecular Diversity and Associated Phenotypic Spectrum of Germline CBL Mutations. |
| Q91718644 | Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis |
| Q38996832 | Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway |
| Q90273272 | Molecular and clinical studies in 107 Noonan syndrome affected individuals with PTPN11 mutations |
| Q85544412 | Molecular mechanism of SHP2 activation by PD-1 stimulation |
| Q46096916 | Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy |
| Q38248429 | Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable. |
| Q35579349 | Molecular targets for the treatment of juvenile myelomonocytic leukemia |
| Q28594140 | Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation |
| Q34043232 | Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells |
| Q54977898 | Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. |
| Q35685296 | Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition |
| Q79811139 | Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia |
| Q79879640 | Mutational analysis of PTPN11 gene in Taiwanese children with Noonan syndrome |
| Q40308333 | Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies |
| Q34137459 | NF1 gene mutations represent the major molecular event underlying neurofibromatosis-Noonan syndrome |
| Q28511483 | Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism |
| Q37135545 | Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells. |
| Q50017932 | Neutrophil CD16b crosslinking induces lipid raft-mediated activation of SHP-2 and affects cytokine expression and retarded neutrophil apoptosis |
| Q37166923 | New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract |
| Q35237519 | Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells |
| Q54149275 | Noonan Syndrome: Genetics and Responsiveness to Growth Hormone Therapy |
| Q59215649 | Noonan syndrome |
| Q34678373 | Noonan syndrome and clinically related disorders |
| Q37112471 | Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation |
| Q34421680 | Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling. |
| Q38631424 | Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation |
| Q38861759 | Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation. |
| Q40587895 | Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation |
| Q35837138 | Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature. |
| Q91915366 | Noonan syndrome-causing genes: Molecular update and an assessment of the mutation rate |
| Q39917153 | Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis |
| Q33806161 | Noonan syndrome: clinical aspects and molecular pathogenesis |
| Q43197770 | Noonan syndrome: prenatal diagnosis in a woman carrying a PTPN11 gene mutation |
| Q33565239 | Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents |
| Q40048797 | Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 activated by B lymphocyte stimulation with antigen |
| Q46620423 | Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. |
| Q34493945 | Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints |
| Q30532837 | Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling |
| Q36016958 | Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7. |
| Q92219916 | Ortho-Topolin Riboside Induced Differentiation through Inhibition of STAT3 Signaling in Acute Myeloid Leukemia HL-60 Cells |
| Q43961757 | Overexpression of Shp-2 attenuates apoptosis in neonatal rat cardiac myocytes through the ERK pathway |
| Q41772799 | Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia |
| Q43289848 | Overexpression of protein phosphatase non-receptor type 11 (PTPN11) in gastric carcinomas |
| Q34347206 | PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta |
| Q52689084 | PD-1 is required to maintain stem cell properties in human dental pulp stem cells. |
| Q37474915 | PD-1 signaling in primary T cells |
| Q91713067 | PD-1/PD-L1 pathway: current researches in cancer |
| Q35061384 | PLCβ1-SHP-2 complex, PLCβ1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling? |
| Q24317102 | PTP-1B is an essential positive regulator of platelet integrin signaling |
| Q33685586 | PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice |
| Q28288812 | PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects |
| Q35616065 | PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase |
| Q36025665 | PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots? |
| Q39232252 | PTPN12 controls PTEN and the AKT signalling to FAK and HER2 in migrating ovarian cancer cells |
| Q34056454 | PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice |
| Q40410431 | Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor |
| Q36178682 | Partitioning the heart: mechanisms of cardiac septation and valve development |
| Q89951249 | Pathogenic PTPN11 variants involving the poly-glutamine Gln255 -Gln256 -Gln257 stretch highlight the relevance of helix B in SHP2's functional regulation |
| Q92966111 | Phagocytosis checkpoints as new targets for cancer immunotherapy |
| Q36673202 | Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism. |
| Q84136085 | Phenotypic spectrum of 80 Greek patients referred as Noonan syndrome and PTPN11 mutation analysis: the value of initial clinical assessment |
| Q46661965 | Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. |
| Q35764349 | Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects |
| Q37389005 | Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction |
| Q37728541 | Phosphatase regulation of intercellular junctions |
| Q37102143 | Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development |
| Q38327588 | Phosphatidylinositol phosphate kinase type Igamma directly associates with and regulates Shp-1 tyrosine phosphatase. |
| Q28542750 | Phosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndrome |
| Q40549975 | Phosphorylation and recruitment of Syk by immunoreceptor tyrosine-based activation motif-based phosphorylation of tamalin |
| Q37823682 | Phosphorylation meets nuclear import: a review |
| Q28386527 | Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease |
| Q37611336 | Physiological signaling specificity by protein tyrosine phosphatases |
| Q24298387 | Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1 |
| Q36731467 | Plexin B1 inhibits MET through direct association and regulates Shp2 expression in melanocytes |
| Q37156868 | Polymorphism in the CagA EPIYA motif impacts development of gastric cancer. |
| Q34487669 | Polymorphisms in the intermediate region of VacA impact Helicobacter pylori-induced disease development |
| Q51092278 | Prediction of substrate sites for protein phosphatases 1B, SHP-1, and SHP-2 based on sequence features. |
| Q35101627 | Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis |
| Q58749617 | Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling |
| Q43166807 | Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase |
| Q36078326 | Protein tyrosine phosphatase SHP-1 sensitizes EGFR/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2. |
| Q36414318 | Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling |
| Q37257055 | Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development |
| Q39207570 | Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. |
| Q36713273 | Protein tyrosine phosphatase function: the substrate perspective |
| Q34295063 | Protein tyrosine phosphatases as potential therapeutic targets |
| Q49356041 | Protein tyrosine phosphatases in cardiac physiology and pathophysiology |
| Q28646447 | Protein tyrosine phosphatases in the JAK/STAT pathway |
| Q24622527 | Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction |
| Q29614826 | Protein tyrosine phosphatases: from genes, to function, to disease |
| Q37094061 | Protein tyrosine phosphatases: functional inferences from mouse models and human diseases. |
| Q37094065 | Protein tyrosine phosphatases: regulatory mechanisms |
| Q35676347 | Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2. |
| Q42817698 | Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration. |
| Q35080194 | Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst |
| Q46216895 | Protein-tyrosine phosphatase activity maintains the viability of hairy cells and modulates their response to interferon-alpha |
| Q36430193 | Protein-tyrosine phosphatases and cancer |
| Q36370775 | Proteomic responses to elevated ocean temperature in ovaries of the ascidian Ciona intestinalis. |
| Q45285840 | Ptpn11 Deletion in CD4+ Cells Does Not Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner |
| Q24632905 | Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis |
| Q36117614 | Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia |
| Q46968616 | Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia |
| Q34627120 | Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. |
| Q38068387 | Ras/MAPK syndromes and childhood hemato-oncological diseases |
| Q41916478 | Reactive oxygen species and epidermal growth factor are antagonistic cues controlling SHP-2 dimerization |
| Q36639759 | Recent understanding of IBD pathogenesis: implications for future therapies |
| Q33893558 | Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP |
| Q41893027 | Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β. |
| Q34408301 | Reciprocal regulation of axonal Filopodia and outgrowth during neuromuscular junction development |
| Q39903938 | Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis |
| Q37797502 | Redox Regulation of Protein Tyrosine Phosphatases: Structural and Chemical Aspects |
| Q46246353 | Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome |
| Q42437631 | Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR. |
| Q24321087 | Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1 |
| Q80691530 | Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2 |
| Q54981177 | Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review. |
| Q26778080 | Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation |
| Q39390200 | Regulation of Nephrin Phosphorylation in Diabetes and Chronic Kidney Injury |
| Q24322588 | Regulation of RhoA-dependent ROCKII activation by Shp2 |
| Q40532735 | Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus |
| Q34354087 | Regulation of kidney development by Shp2: an unbiased stereological analysis. |
| Q28394373 | Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation |
| Q90670400 | Regulation of virus-triggered type I interferon signaling by cellular and viral proteins |
| Q48103763 | Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases. |
| Q24315911 | Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation |
| Q40459023 | Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2. |
| Q89793206 | Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR |
| Q35965257 | Retrovirus budding. |
| Q99571808 | Revisiting the PD-1 pathway |
| Q36631442 | Role of CEACAM1 as a regulator of T cells |
| Q36999895 | Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome |
| Q37363383 | Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification |
| Q36286876 | Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. |
| Q33877092 | Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells |
| Q37263070 | Role of protein-tyrosine phosphatases in regulation of osteoclastic activity. |
| Q39670881 | Role of the protein tyrosine phosphatase SHP‐1 in Interleukin‐6 regulation of prostate cancer cells |
| Q28508604 | Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium |
| Q24301556 | Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor |
| Q36155130 | SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice |
| Q27684212 | SHP family protein tyrosine phosphatases adopt canonical active-site conformations in the apo and phosphate-bound states |
| Q30436912 | SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels |
| Q52579820 | SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling. |
| Q35837774 | SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells |
| Q36118946 | SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth |
| Q37701953 | SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation |
| Q37438081 | SHP-2 expression negatively regulates NK cell function |
| Q37662297 | SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development |
| Q35615838 | SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl |
| Q39298327 | SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon-β production |
| Q46784050 | SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively |
| Q40550696 | SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway |
| Q33941989 | SHP-2 promotes the maturation of oligodendrocyte precursor cells through Akt and ERK1/2 signaling in vitro |
| Q42831977 | SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway |
| Q48162328 | SHP-2 restricts apoptosis induced by chemotherapeutic agents via Parkin-dependent autophagy in cervical cancer. |
| Q37186707 | SHP-2 tyrosine phosphatase in human diseases. |
| Q35720694 | SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. |
| Q34290934 | SHP2 Mediates the Localized Activation of Fyn Downstream of the α6β4 Integrin To Promote Carcinoma Invasion |
| Q40662726 | SHP2 and UGP2 are Biomarkers for Progression and Poor Prognosis of Gallbladder Cancer |
| Q53080575 | SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors. |
| Q42905618 | SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells |
| Q34554631 | SHP2 is a target of the immunosuppressant tautomycetin |
| Q46361900 | SHP2 is required for BCR-ABL1-induced hematologic neoplasia. |
| Q43131040 | SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene |
| Q41593253 | SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells |
| Q38694762 | SHP2 overexpression enhances the invasion and metastasis of ovarian cancer in vitro and in vivo |
| Q37687479 | SHP2 phosphatase as a novel therapeutic target for melanoma treatment |
| Q41908225 | SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver |
| Q34009953 | SHP2E76K mutant promotes lung tumorigenesis in transgenic mice |
| Q36058958 | SIRP/CD47 signaling in neurological disorders |
| Q28565762 | SIRPα interacts with nephrin at the podocyte slit diaphragm |
| Q36326310 | SNP interactions of Helicobacter pylori-related host genes PGC, PTPN11, IL1B, and TLR4 in susceptibility to gastric carcinogenesis |
| Q36481526 | SRC family kinases and receptors: analysis of three activation mechanisms by dynamic systems modeling |
| Q27659942 | Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) |
| Q27700205 | Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo |
| Q36322254 | Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. |
| Q57791533 | Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes |
| Q79456661 | Sending out an SOS |
| Q33612053 | Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein |
| Q33243531 | Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position |
| Q24297942 | Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells |
| Q62658228 | Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells |
| Q39981493 | Shp-2 knockdown prevents l-dopa-induced dyskinesia in a rat model of Parkinson's disease. |
| Q36973659 | Shp1 regulates T cell homeostasis by limiting IL-4 signals |
| Q33851655 | Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool |
| Q36574874 | Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury. |
| Q37631584 | Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3 |
| Q35832364 | Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development |
| Q34339747 | Shp2 activates Fyn and Ras to regulate RBL-2H3 mast cell activation following FcεRI aggregation |
| Q42556882 | Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development |
| Q36238390 | Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals |
| Q36379387 | Shp2 as a therapeutic target for leptin resistance and obesity |
| Q52367078 | Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET. |
| Q35825659 | Shp2 function in hematopoietic stem cell biology and leukemogenesis |
| Q30399984 | Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice |
| Q90848336 | Shp2 in myocytes is essential for cardiovascular and neointima development |
| Q52012657 | Shp2 is dispensable in the formation and maintenance of the neuromuscular junction. |
| Q27314678 | Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects |
| Q36637373 | Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity |
| Q38722719 | Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients. |
| Q33782482 | Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs |
| Q42831428 | Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment |
| Q47093822 | Shp2 regulates migratory behavior and response to EGFR-TKIs through ERK1/2 pathway activation in non-small cell lung cancer cells |
| Q35761138 | Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice. |
| Q34433715 | Shp2 suppresses PyMT-induced transformation in mouse fibroblasts by inhibiting Stat3 activity |
| Q49167741 | Shp2-Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration |
| Q28282489 | Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation |
| Q37627932 | Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine |
| Q34399676 | Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL. |
| Q36293523 | Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27. |
| Q40048491 | Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition |
| Q40199892 | Signaling perturbations induced by invading H. pylori proteins in the host epithelial cells: a mathematical modeling approach |
| Q54561499 | Significant association between PTPN11 polymorphism and gastric atrophy among Japanese Brazilians. |
| Q40388136 | Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells |
| Q28476397 | Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin |
| Q27671220 | Simultaneous Binding of Two Peptidyl Ligands by a Src Homology 2 Domain |
| Q93239307 | Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2 |
| Q33931319 | Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening |
| Q102203509 | Small molecule inhibitors of Shp2 phosphatase as potential chemotherapeutic agents for glioblastoma: A mini-review |
| Q26852276 | Small molecule tools for functional interrogation of protein tyrosine phosphatases |
| Q46447357 | Somatic PTPN11 mutations in childhood acute myeloid leukaemia |
| Q35735401 | Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder |
| Q36734746 | Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. |
| Q41973102 | Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. |
| Q33714226 | Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development |
| Q47998759 | Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis |
| Q64250427 | Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets |
| Q38221447 | Steroidogenesis-adrenal cell signal transduction |
| Q39671274 | Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test |
| Q38180279 | Stromal regulation of embryonic and postnatal mammary epithelial development and differentiation |
| Q36989335 | Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. |
| Q27676674 | Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations |
| Q33556868 | Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11) |
| Q42716640 | Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase. |
| Q58097695 | Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition |
| Q26825507 | Structure and function of Gab2 and its role in cancer (Review) |
| Q39245190 | Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer |
| Q35781235 | Structure-based kinetic models of modular signaling protein function: focus on Shp2. |
| Q38187201 | Sun-induced freckling: ephelides and solar lentigines |
| Q35822851 | Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity |
| Q61808037 | Synergistic effects of SHP2 and PI3K pathway inhibitors in GAB2-overexpressing ovarian cancer |
| Q37702574 | T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice |
| Q28590621 | T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation |
| Q36208936 | TSLP signaling network revealed by SILAC-based phosphoproteomics |
| Q45754279 | Targeted/exome sequencing identified mutations in ten Chinese patients diagnosed with Noonan syndrome and related disorders. |
| Q37293656 | Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma |
| Q35001128 | Targeting a cryptic allosteric site for selective inhibition of the oncogenic protein tyrosine phosphatase Shp2 |
| Q38261370 | Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention |
| Q34789961 | Targeting protein tyrosine phosphatases for anticancer drug discovery |
| Q59790569 | The Allosteric Site on SHP2's Protein Tyrosine Phosphatase Domain is Targetable with Druglike Small Molecules |
| Q28250501 | The CD155/poliovirus receptor enhances the proliferation of ras-mutated cells |
| Q38195828 | The CD47-SIRPα signalling system: its physiological roles and therapeutic application |
| Q39636154 | The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Contains an Immunoreceptor Tyrosine-Based Inhibitory Motif That Activates Shp2 |
| Q28066941 | The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation |
| Q37159467 | The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders |
| Q38864897 | The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system |
| Q38747863 | The SHP2-ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of CCAAT/enhancer binding protein α to the IGnTC promoter region during erythroid differentiation |
| Q36528106 | The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42 |
| Q39167879 | The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases |
| Q41296343 | The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway |
| Q33353881 | The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters |
| Q35447328 | The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis |
| Q24292713 | The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling |
| Q91864877 | The molecular details of cytokine signaling via the JAK/STAT pathway |
| Q35847884 | The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease |
| Q34567819 | The natural history of Noonan syndrome: a long-term follow-up study |
| Q31120295 | The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42 |
| Q36025321 | The orexin receptor OX(1)R in colon cancer: a promising therapeutic target and a new paradigm in G protein-coupled receptor signalling through ITIMs. |
| Q37405181 | The phosphatase SHP2 regulates the spacing effect for long-term memory induction |
| Q37617410 | The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon |
| Q37564987 | The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo |
| Q37123801 | The role and target potential of protein tyrosine phosphatases in cancer |
| Q36659807 | The role of Helicobacter pylori CagA in gastric carcinogenesis |
| Q33577586 | The role of Src homology 2 containing protein tyrosine phosphatase 2 in vascular smooth muscle cell migration and proliferation |
| Q52571988 | The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells. |
| Q35118478 | The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease. |
| Q40193180 | The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. |
| Q50336720 | The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway |
| Q39314223 | The tyrosine phosphatase SHP-1 negatively regulates cytotrophoblast proliferation in first-trimester human placenta by modulating EGFR activation |
| Q39016533 | The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V. |
| Q36356541 | The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation |
| Q53272023 | The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1) -mediated Erk signaling in striatal neurons. |
| Q37342975 | The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development |
| Q39455165 | The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney. |
| Q37732956 | The tyrosine phosphatase Shp2 in development and cancer |
| Q34061302 | Therapeutic potential of targeting the oncogenic SHP2 phosphatase |
| Q37151702 | Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells |
| Q35903618 | Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair. |
| Q38247744 | Translational hematology |
| Q93273295 | Turn and Face the Strange: A New View on Phosphatases |
| Q33861226 | Twin infant with lymphatic dysplasia diagnosed with Noonan syndrome by molecular genetic testing |
| Q33279689 | Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft. |
| Q36206435 | Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice |
| Q40949874 | Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity. |
| Q35630243 | Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses |
| Q33928558 | Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor |
| Q34007299 | Tyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development |
| Q37970047 | Tyrosine phosphorylation and liver regeneration: A glance at intracellular transducers. |
| Q40384638 | Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase |
| Q92637757 | Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2 |
| Q41837242 | Upregulation of immunoregulatory Src homology 2 molecule containing inositol phosphatase and mononuclear cell hyporesponsiveness in oral mucosa during chronic periodontitis |
| Q36324934 | alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology |
| Q43582853 | ¹H, ¹³C and ¹⁵N backbone and side-chain chemical shift assignments of the free and bound forms of the human PTPN11 second SH2 domain |
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