| scholarly article | Q13442814 |
| P2093 | author name string | Gjalt W Huisman | |
| Roger A Sheldon | |||
| Emily C Mundorff | |||
| Sarena Tam | |||
| Richard J Fox | |||
| Lisa M Newman | |||
| Steven K Ma | |||
| Sheela Muley | |||
| Vesna Gavrilovic | |||
| Loleta M Chung | |||
| Charlene Ching | |||
| John C Whitman | |||
| John Grate | |||
| John Gruber | |||
| S Christopher Davis | |||
| P2860 | cites work | DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution | Q24562755 |
| Directed evolution strategies for improved enzymatic performance | Q24815563 | ||
| Structure and mechanism of a bacterial haloalcohol dehalogenase: a new variation of the short-chain dehydrogenase/reductase fold without an NAD(P)H binding site | Q27642251 | ||
| Rapid evolution of a protein in vitro by DNA shuffling | Q28245873 | ||
| DNA shuffling of a family of genes from diverse species accelerates directed evolution | Q28259708 | ||
| DNA shuffling of subgenomic sequences of subtilisin | Q30764607 | ||
| Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently | Q30869909 | ||
| Discovery and directed evolution of a glyphosate tolerance gene | Q31064276 | ||
| Directed molecular evolution by machine learning and the influence of nonlinear interactions | Q31152500 | ||
| Optimizing the search algorithm for protein engineering by directed evolution | Q31156587 | ||
| Dispelling the myths--biocatalysis in industrial synthesis | Q33186387 | ||
| Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis. | Q33212124 | ||
| Laboratory-directed protein evolution | Q33222949 | ||
| Industrial biocatalysis today and tomorrow | Q33934410 | ||
| Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening | Q36137488 | ||
| Engineering multiple properties of a protein by combinatorial mutagenesis | Q36528125 | ||
| Halohydrin dehalogenases are structurally and mechanistically related to short-chain dehydrogenases/reductases | Q39504556 | ||
| Purification and characterization of haloalcohol dehalogenase from Arthrobacter sp. strain AD2 | Q39938742 | ||
| A new catalytic function of halohydrin hydrogen-halide-lyase, synthesis of beta-hydroxynitriles from epoxides and cyanide | Q42006425 | ||
| Additivity of mutational effects in proteins | Q46528565 | ||
| Biochemistry. Loop grafting and the origins of enzyme species. | Q51281359 | ||
| Towards a theory of evolutionary adaptation. | Q52237130 | ||
| SIMPLS: An alternative approach to partial least squares regression | Q56454405 | ||
| Directed evolution of enantioselective enzymes: iterative cycles of CASTing for probing protein-sequence space | Q56899243 | ||
| Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications | Q59204186 | ||
| P433 | issue | 3 | |
| P304 | page(s) | 338-344 | |
| P577 | publication date | 2007-02-18 | |
| P1433 | published in | Nature Biotechnology | Q1893837 |
| P1476 | title | Improving catalytic function by ProSAR-driven enzyme evolution | |
| P478 | volume | 25 |
| Q61816855 | A Computational Method to Propose Mutations in Enzymes Based on Structural Signature Variation (SSV) |
| Q35220501 | A high-throughput adrenaline test for the exploration of the catalytic potential of halohydrin dehalogenases in epoxide ring-opening reactions |
| Q59335273 | A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes |
| Q38663511 | A receptor dependent-4D QSAR approach to predict the activity of mutated enzymes |
| Q51450251 | ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution. |
| Q33812427 | Algorithms for automated DNA assembly |
| Q35585831 | An efficient high-throughput screening assay for rapid directed evolution of halohydrin dehalogenase for preparation of β-substituted alcohols. |
| Q57455884 | Application of fourier transform and proteochemometrics principles to protein engineering |
| Q38358691 | Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape |
| Q35161643 | Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis. |
| Q56894908 | Asymmetric synthesis of D-glyceric acid by an alditol oxidase and directed evolution for enhanced oxidative activity towards glycerol |
| Q28544455 | BioGPS descriptors for rational engineering of enzyme promiscuity and structure based bioinformatic analysis |
| Q38770699 | Biocatalysis with Unnatural Amino Acids: Enzymology Meets Xenobiology |
| Q33695381 | Biocatalysts by evolution |
| Q38265408 | Biocatalysts: application and engineering for industrial purposes |
| Q59907479 | Biocatalytic Cascade for the Synthesis of Enantiopure β-Azidoalcohols and β-Hydroxynitriles |
| Q27684415 | Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase |
| Q34121402 | Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture |
| Q38835851 | Bioinformatics for the synthetic biology of natural products: integrating across the Design-Build-Test cycle |
| Q92778267 | Broadening the Scope of Biocatalysis in Sustainable Organic Synthesis |
| Q36294688 | CADEE: Computer-Aided Directed Evolution of Enzymes |
| Q42034073 | Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases |
| Q38162729 | Chemical and enzymatic approaches to the synthesis of optically pure ethyl (R)-4-cyano-3-hydroxybutanoate. |
| Q38104437 | Computational design gains momentum in enzyme catalysis engineering |
| Q38092809 | Computational enzyme design |
| Q30394571 | Computational protein engineering: bridging the gap between rational design and laboratory evolution |
| Q34948584 | Computational structure-based redesign of enzyme activity |
| Q35136550 | Computational tools for rational protein engineering of aldolases |
| Q38798703 | Computational tools for the evaluation of laboratory-engineered biocatalysts |
| Q90274270 | Computer-Assisted Recombination (CompassR) Teaches us How to Recombine Beneficial Substitutions from Directed Evolution Campaigns |
| Q50160793 | Darwin Assembly: fast, efficient, multi-site bespoke mutagenesis. |
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| Q37244268 | Directed enzyme evolution: climbing fitness peaks one amino acid at a time |
| Q38421409 | Directed evolution 2.0: improving and deciphering enzyme properties |
| Q21045409 | Directed evolution drives the next generation of biocatalysts |
| Q34580985 | Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas. |
| Q56896643 | Directed evolution of hydrolases for prevention of G-type nerve agent intoxication |
| Q31042124 | Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks |
| Q34095513 | Directed evolution to re-adapt a co-evolved network within an enzyme. |
| Q28275218 | Directed evolution: tailoring biocatalysts for industrial applications |
| Q37695439 | Directed polymerase evolution. |
| Q38987170 | Directing positional specificity in enzymatic synthesis of bioactive 1-phosphatidylinositol by protein engineering of a phospholipase D. |
| Q57189276 | Discovery and Protein Engineering of Biocatalysts for Organic Synthesis |
| Q37278358 | Engineered enzymes for chemical production |
| Q34085877 | Engineering of biocatalysts - from evolution to creation |
| Q34274077 | Engineering the third wave of biocatalysis |
| Q50907436 | Enhanced enzymatic reactions by solar-to-thermal conversion nanoparticles. |
| Q34347644 | Enhancement of the substrate scope of transketolase. |
| Q36271261 | Enhancing the biocatalytic manufacture of the key intermediate of atorvastatin by focused directed evolution of halohydrin dehalogenase |
| Q34204232 | Enhancing the efficiency of directed evolution in focused enzyme libraries by the adaptive substituent reordering algorithm. |
| Q57015779 | Enzyme engineering toolbox – a ‘catalyst’ for change |
| Q30367602 | Enzyme improvement in the absence of structural knowledge: a novel statistical approach. |
| Q47433882 | Enzyme stabilization via computationally guided protein stapling |
| Q90232603 | Enzymes from Marine Polar Regions and Their Biotechnological Applications |
| Q27678090 | Evolving P450pyr hydroxylase for highly enantioselective hydroxylation at non-activated carbon atom |
| Q34595210 | Expanding the Halohydrin Dehalogenase Enzyme Family: Identification of Novel Enzymes by Database Mining |
| Q35504479 | Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution |
| Q28710543 | Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing |
| Q24635353 | Exploiting models of molecular evolution to efficiently direct protein engineering |
| Q35221137 | Exploring the enantioselective mechanism of halohydrin dehalogenase from Agrobacterium radiobacter AD1 by iterative saturation mutagenesis |
| Q36245944 | Exploring the thermostable properties of halohydrin dehalogenase from Agrobacterium radiobacter AD1 by a combinatorial directed evolution strategy |
| Q54290181 | Expression, characterization, and improvement of a newly cloned halohydrin dehalogenase from Agrobacterium tumefaciens and its application in production of epichlorohydrin. |
| Q34987765 | Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay |
| Q60399031 | Extending the application of biocatalysis to meet the challenges of drug development |
| Q51832459 | Facile synthesis of multiple enzyme-containing metal-organic frameworks in a biomolecule-friendly environment. |
| Q57189348 | Finding better protein engineering strategies |
| Q41862260 | Fitness loss and library size determination in saturation mutagenesis |
| Q92319719 | GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries |
| Q38680071 | Global analysis of protein folding using massively parallel design, synthesis, and testing |
| Q37345640 | How a single-point mutation in horseradish peroxidase markedly enhances enantioselectivity |
| Q42046974 | Improving biocatalyst performance by integrating statistical methods into protein engineering |
| Q47313954 | Integrating protein engineering with process design for biocatalysis |
| Q33801589 | Interplay of metagenomics and in vitro compartmentalization. |
| Q27676283 | Janus: Prediction and Ranking of Mutations Required for Functional Interconversion of Enzymes |
| Q62730592 | Learned protein embeddings for machine learning |
| Q45942993 | Learning epistatic interactions from sequence-activity data to predict enantioselectivity. |
| Q102319739 | Machine learning for metabolic engineering: A review |
| Q93064946 | Machine learning-assisted directed protein evolution with combinatorial libraries |
| Q91905099 | Machine-learning-guided directed evolution for protein engineering |
| Q36545654 | Navigating the protein fitness landscape with Gaussian processes |
| Q37847523 | Novel carbon-carbon bond formations for biocatalysis |
| Q43182433 | One pot 'click' reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition |
| Q34020780 | Optimization of combinatorial mutagenesis. |
| Q64056985 | Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity |
| Q34311541 | Probing the mutational interplay between primary and promiscuous protein functions: a computational-experimental approach |
| Q37860247 | Process considerations for the asymmetric synthesis of chiral amines using transaminases. |
| Q38056627 | Properties and biotechnological applications of halohydrin dehalogenases: current state and future perspectives |
| Q57794249 | Protein design: from computer models to artificial intelligence |
| Q45086247 | Protein engineering from "scratch" is maturing |
| Q56895196 | Protein engineering of stereoselective Baeyer-Villiger monooxygenases |
| Q33635299 | Rapid profiling of a microbial genome using mixtures of barcoded oligonucleotides |
| Q33703675 | Rational assignment of key motifs for function guides in silico enzyme identification |
| Q28072611 | Recent advances on halohydrin dehalogenases-from enzyme identification to novel biocatalytic applications |
| Q44488993 | Recombinant production and characterization of an N-Acyl-D-amino acid amidohydrolase from Streptomyces sp. 64E6. |
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| Q38294224 | Robust enzyme design: bioinformatic tools for improved protein stability |
| Q56898496 | Sequence-activity relationships guide directed evolution |
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| Q36145664 | SpeedyGenes: Exploiting an Improved Gene Synthesis Method for the Efficient Production of Synthetic Protein Libraries for Directed Evolution |
| Q31064145 | Strategy for directing combinatorial genome engineering in Escherichia coli. |
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| Q56895981 | Survey of protein engineering strategies |
| Q51640185 | Synthesis aided design: The biological design-build-test engineering paradigm? |
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| Q90609739 | The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis |
| Q37874451 | The importance of green chemistry in process research and development |
| Q27683292 | The role of distant mutations and allosteric regulation on LovD active site dynamics |
| Q38845675 | The role of side chain entropy and mutual information for improving the de novo design of Kemp eliminases KE07 and KE70. |
| Q26800022 | Thermostable Carbonic Anhydrases in Biotechnological Applications |
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