| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.3390/NU9101060 |
| P8608 | Fatcat ID | release_o6de4rjdmreuxagvw77lnvwz4y |
| P932 | PMC publication ID | 5691677 |
| P698 | PubMed publication ID | 28954409 |
| P50 | author | Kok-Lun Pang | Q88423211 |
| Kok-Yong Chin | Q41338399 | ||
| P2093 | author name string | Kok-Lun Pang | |
| P2860 | cites work | Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes | Q21195248 |
| The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial | Q24630475 | ||
| Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity | Q24647370 | ||
| Olives and Bone: A Green Osteoporosis Prevention Option | Q26740524 | ||
| A simple practice guide for dose conversion between animals and human | Q26750843 | ||
| Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis | Q26786235 | ||
| Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression | Q26998603 | ||
| Post-operative rehabilitation and nutrition in osteoarthritis | Q27015122 | ||
| Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys | Q28074508 | ||
| Nutraceutical Supplements in the Management and Prevention of Osteoarthritis | Q28076979 | ||
| The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds | Q28078985 | ||
| Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use | Q28081433 | ||
| Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production | Q28115730 | ||
| Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans | Q28205071 | ||
| Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line | Q28274908 | ||
| Further evidence for the anti-inflammatory activity of oleocanthal: inhibition of MIP-1α and IL-6 in J774 macrophages and in ATDC5 chondrocytes | Q28276558 | ||
| Olive oil phenolics are dose-dependently absorbed in humans | Q28371814 | ||
| Hydroxytyrosol prevents increase of osteoarthritis markers in human chondrocytes treated with hydrogen peroxide or growth-related oncogene α | Q28543546 | ||
| Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity | Q28583282 | ||
| Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration. | Q45027551 | ||
| Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition | Q45070109 | ||
| Effects of dietary extra-virgin olive oil on oxidative stress resulting from exhaustive exercise in rat skeletal muscle: a morphological study | Q46105163 | ||
| The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production | Q46401918 | ||
| Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats | Q46459704 | ||
| Fas/Fas ligand expression and induction of apoptosis in chondrocytes | Q46465417 | ||
| Oleuropein induces mitochondrial biogenesis and decreases reactive oxygen species generation in cultured avian muscle cells, possibly via an up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α. | Q46473325 | ||
| Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis | Q46497824 | ||
| Olive phenolic compounds attenuate deltamethrin-induced liver and kidney toxicity through regulating oxidative stress, inflammation and apoptosis | Q46608080 | ||
| Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage | Q46767968 | ||
| Olive oil and its phenolic constituent tyrosol attenuates dioxin-induced toxicity in peripheral blood mononuclear cells via an antioxidant-dependent mechanism | Q46800097 | ||
| Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint | Q46805543 | ||
| Extra virgin olive oil blunt post-prandial oxidative stress via NOX2 down-regulation | Q46872541 | ||
| Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. | Q46952247 | ||
| Role of nitric oxide-induced mtDNA damage in mitochondrial dysfunction and apoptosis | Q46977810 | ||
| Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and fluid synovial fibroblasts | Q47742431 | ||
| Bioaccessibility of hydroxytyrosol and n-3 fatty acids as affected by the delivery system: simple, double and gelled double emulsions | Q48105936 | ||
| RETRACTED: Polar and apolar extra virgin olive oil and leaf extracts as a promising anti-inflammatory natural treatment for osteoarthritis | Q50170545 | ||
| Detection of superoxide and NADPH oxidase in porcine articular chondrocytes | Q73695200 | ||
| The in vivo fate of hydroxytyrosol and tyrosol, antioxidant phenolic constituents of olive oil, after intravenous and oral dosing of labeled compounds to rats | Q74130231 | ||
| Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants | Q77794026 | ||
| Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis | Q79318170 | ||
| Evidence for a protective role for adiponectin in osteoarthritis | Q80064580 | ||
| Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments | Q81270816 | ||
| Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit | Q83425376 | ||
| A pilot double-blinded, randomized, clinical trial of topical virgin olive oil versus piroxicam gel in osteoarthritis of the knee | Q83447320 | ||
| Combined effects of TNF-α, IL-1β, and HIF-1α on MMP-2 production in ACL fibroblasts under mechanical stretch: an in vitro study | Q83462753 | ||
| The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes | Q85411133 | ||
| Unsaponifiable Fraction of Unripe Fruits of Olea europaea: An Interesting Source of Anti-inflammatory Constituents | Q86640368 | ||
| Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee | Q30992895 | ||
| Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial | Q32050561 | ||
| Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study | Q32174010 | ||
| Role of autophagy in the progression of osteoarthritis: The autophagy inhibitor, 3-methyladenine, aggravates the severity of experimental osteoarthritis | Q33598969 | ||
| Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis | Q33636462 | ||
| Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression | Q33687969 | ||
| Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis | Q33729300 | ||
| Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model | Q33893466 | ||
| Systematic identification of novel protein domain families associated with nuclear functions | Q34108188 | ||
| Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis. | Q34349423 | ||
| The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study | Q34405510 | ||
| The biology of lubricin: near frictionless joint motion | Q34436012 | ||
| Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells | Q34494270 | ||
| The role of reactive oxygen species in homeostasis and degradation of cartilage | Q34537354 | ||
| Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator | Q34574562 | ||
| A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. | Q34588182 | ||
| Monounsaturated and Saturated, but Not n-6 Polyunsaturated Fatty Acids Decrease Cartilage Destruction under Inflammatory Conditions: A Preliminary Study. | Q34978113 | ||
| Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase | Q35128583 | ||
| Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes | Q35215468 | ||
| Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic Acid and hydroxytyrosol in human adipocytes | Q35647737 | ||
| Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides | Q35766373 | ||
| Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. | Q35907720 | ||
| Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms. | Q35946979 | ||
| Protective Effect of Tyrosol and S-Adenosylmethionine against Ethanol-Induced Oxidative Stress of Hepg2 Cells Involves Sirtuin 1, P53 and Erk1/2 Signaling. | Q36003472 | ||
| Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. | Q37021544 | ||
| Glucosamine activates autophagy in vitro and in vivo | Q37168084 | ||
| Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease | Q37211903 | ||
| Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption | Q37264662 | ||
| Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance | Q37267822 | ||
| Extracellular superoxide dismutase and oxidant damage in osteoarthritis. | Q37371108 | ||
| Fatty Acid and Phenolic Compound Concentrations in Eight Different Monovarietal Virgin Olive Oils from Extremadura and the Relationship with Oxidative Stability | Q37465796 | ||
| Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes | Q37691067 | ||
| Physiological significance of selective degradation of p62 by autophagy | Q37691820 | ||
| Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes | Q38227979 | ||
| Characterization of extra virgin olive oils produced with typical Italian varieties by their phenolic profile. | Q50448133 | ||
| Evaluation of prolidase activity and oxidative status in patients with knee osteoarthritis: relationships with radiographic severity and clinical parameters. | Q50552704 | ||
| Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis. | Q50933999 | ||
| Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. | Q50948674 | ||
| Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice. | Q51002439 | ||
| Protective effects of hydroxytyrosol on liver ischemia/reperfusion injury in mice. | Q51014765 | ||
| Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis. | Q51429246 | ||
| Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. | Q51767105 | ||
| Expression of adipokines in osteoarthritis osteophytes and their effect on osteoblasts. | Q52955096 | ||
| Comparison of simple, double and gelled double emulsions as hydroxytyrosol and n-3 fatty acid delivery systems. | Q52986621 | ||
| Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. | Q55041681 | ||
| Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death | Q56960745 | ||
| MMP-13 (collagenase 3) localization in human temporomandibular joint discs with internal derangement | Q57764976 | ||
| Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis | Q57983067 | ||
| Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels | Q59640767 | ||
| Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression | Q60229481 | ||
| Immunolocalization and expression of lubricin in the bilaminar zone of the human temporomandibular joint disc | Q60229487 | ||
| β-Defensin-4 (HBD-4) is expressed in chondrocytes derived from normal and osteoarthritic cartilage encapsulated in PEGDA scaffold | Q60229494 | ||
| Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments. | Q64924982 | ||
| Release of oxygen radicals by articular chondrocytes: A study of luminol‐dependent chemiluminescence and hydrogen peroxide secretion | Q67465102 | ||
| Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines | Q68340509 | ||
| Chondrocyte multiplication in osteoarthritic articular cartilage | Q69568844 | ||
| Differential levels of synovial fluid aggrecan aggregate components in experimental osteoarthritis and joint disuse | Q71641482 | ||
| Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization | Q38297886 | ||
| Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism | Q38303866 | ||
| Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis | Q38338692 | ||
| Evidence for a key role of leptin in osteoarthritis | Q38348145 | ||
| Effects of leptin to cultured growth plate chondrocytes | Q38352328 | ||
| Autophagy in osteoarthritis | Q38603339 | ||
| Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies | Q38795240 | ||
| Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. | Q38885757 | ||
| Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig. | Q39129552 | ||
| Transdermal anti-inflammatory activity of bilayer film containing olive compound hydroxytyrosol: physical assessment, in vivo dermal safety and efficacy study in Freund's adjuvant-induced arthritic rat model | Q39428769 | ||
| Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-β-induced toxicity. Involvement of the NF-κB signaling | Q39538052 | ||
| Expression of β-defensin-4 in "an in vivo and ex vivo model" of human osteoarthritic knee meniscus | Q39712435 | ||
| Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. | Q39890595 | ||
| Impact of olive oil-rich diet on serum omentin and adiponectin levels: a randomized cross-over clinical trial among overweight women. | Q40435027 | ||
| Minimization of Local and Systemic Adverse Effects of Topical Glucocorticoids by Nanoencapsulation: In Vivo Safety of Hydrocortisone-Hydroxytyrosol Loaded Chitosan Nanoparticles. | Q40454177 | ||
| Olive oil compounds inhibit the paracrine regulation of TNF-α-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression | Q40496466 | ||
| Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization | Q40867589 | ||
| The protective role of olive oil hydroxytyrosol against oxidative alterations induced by mercury in human erythrocytes | Q40957332 | ||
| Association study of MMP8 gene in osteoarthritis | Q41118344 | ||
| Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than | Q41201384 | ||
| Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy | Q41357956 | ||
| Post-traumatic caspase-3 expression in the adjacent areas of growth plate injury site: a morphological study | Q42046150 | ||
| Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis | Q42135414 | ||
| Aggrecan and cartilage oligomeric matrix protein in serum and synovial fluid of patients with knee osteoarthritis | Q42514613 | ||
| Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. | Q42783350 | ||
| Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes. | Q43049067 | ||
| Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis | Q43151758 | ||
| Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation. | Q43472887 | ||
| Hypoxia promotes the production and inhibits the destruction of human articular cartilage | Q43491158 | ||
| Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis | Q43546528 | ||
| Olive oil phenols are absorbed in humans | Q43907047 | ||
| Feeding with olive oil attenuates inflammation in dextran sulfate sodium-induced colitis in rat. | Q44044956 | ||
| Expression of gelatinases (MMP-2, MMP-9) in human articular cartilage | Q44085316 | ||
| Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression | Q44246411 | ||
| Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. | Q44398229 | ||
| Hydroxytyrosol disposition in humans | Q44453059 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | polyphenol | Q290439 |
| phenol | Q407142 | ||
| translational medical research | Q474859 | ||
| anti-inflammatory agent | Q581996 | ||
| human musculoskeletal system | Q726543 | ||
| lipid | Q11367 | ||
| eukaryote | Q19088 | ||
| hydrocarbon | Q43648 | ||
| osteoarthritis | Q62736 | ||
| plant structure | Q20011319 | ||
| plant extract | Q65618538 | ||
| pharmaceutical preparation | Q66089252 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P577 | publication date | 2017-09-26 | |
| P1433 | published in | Nutrients | Q7070485 |
| P1476 | title | Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside | |
| P478 | volume | 9 |
| Q55689206 | Activation of the Nrf2/HO-1 Signaling Pathway Contributes to the Protective Effects of Sargassum serratifolium Extract against Oxidative Stress-Induced DNA Damage and Apoptosis in SW1353 Human Chondrocytes. |
| Q58780361 | Effects of Polyphenol-Rich Foods on Human Health |
| Q58796882 | Osteoarthritis and the Mediterranean Diet: A Systematic Review |
| Q93006387 | Safety Evaluations of Single Dose of the Olive Secoiridoid S-(-)-Oleocanthal in Swiss Albino Mice |
| Q53397945 | The Biological Activities of Oleocanthal from a Molecular Perspective. |
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