Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision

scientific article

Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKX870
P932PMC publication ID5716079
P698PubMed publication ID29036709

P50authorYungang XuQ42316519
P2093author name stringXiaobo Zhou
Weiling Zhao
Jiesi Luo
Yongcui Wang
P2860cites workMapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1Q22008789
An integrated encyclopedia of DNA elements in the human genomeQ22122150
Biases in Illumina transcriptome sequencing caused by random hexamer primingQ24620975
Epigenetics in alternative pre-mRNA splicingQ24625879
A survey of computational tools for downstream analysis of proteomic and other omic datasetsQ26778173
Embryonic stem cell lines derived from human blastocystsQ27861010
Alternative isoform regulation in human tissue transcriptomesQ27861118
Deep learningQ28018765
The selection and function of cell type-specific enhancersQ28081960
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skippingQ28269954
SON connects the splicing-regulatory network with pluripotency in human embryonic stem cellsQ28298055
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencingQ29547470
Mapping and analysis of chromatin state dynamics in nine human cell typesQ29547552
RNA processing and its regulation: global insights into biological networksQ29615182
RNA and diseaseQ29615183
Integrative analysis of 111 reference human epigenomesQ29615565
The developmental transcriptome of Drosophila melanogasterQ29617262
The NIH Roadmap Epigenomics Mapping ConsortiumQ29619856
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteinsQ29619879
A convex formulation for learning a shared predictive structure from multiple tasksQ30547055
rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq dataQ30875027
Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissuesQ41410703
Nucleosomes are well positioned in exons and carry characteristic histone modificationsQ41863525
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in DrosophilaQ41951844
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicingQ41999449
RNA splicing. The human splicing code reveals new insights into the genetic determinants of diseaseQ42558500
Deep Neural Networks for Acoustic Modeling in Speech Recognition: The Shared Views of Four Research GroupsQ55871746
Chromatin organization marks exon-intron structureQ57058000
Alternative splicing events identified in human embryonic stem cells and neural progenitorsQ33304209
Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assemblyQ33510906
Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursorsQ33515260
Histone modification levels are predictive for gene expressionQ33624069
Deciphering the splicing codeQ34022324
Regulation of alternative splicing by histone modificationsQ34035543
Combinations of histone modifications mark exon inclusion levelsQ34126698
Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicingQ34276472
Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learningQ34487019
Genome-wide analysis of alternative splicing in Caenorhabditis elegansQ34548324
Functional consequences of developmentally regulated alternative splicingQ34632366
Histone modifications are associated with transcript isoform diversity in normal and cancer cellsQ35182079
Modeling the relationship of epigenetic modifications to transcription factor bindingQ35562092
Predicting protein residue-residue contacts using deep networks and boostingQ36432211
Predicting effects of noncoding variants with deep learning-based sequence modelQ36621822
Transcriptional and epigenetic dynamics during specification of human embryonic stem cellsQ37006585
Lariat sequencing in a unicellular yeast identifies regulated alternative splicing of exons that are evolutionarily conserved with humansQ37068517
Basset: learning the regulatory code of the accessible genome with deep convolutional neural networksQ37076984
Differential chromatin marking of introns and expressed exons by H3K36me3.Q37111430
BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial CellsQ37170604
Epigenomic analysis of multilineage differentiation of human embryonic stem cellsQ37205415
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.Q37601795
Understanding splicing regulation through RNA splicing mapsQ37828274
Alternative splicing in cancer: implications for biology and therapyQ38179828
H3K4me2 reliably defines transcription factor binding regions in different cellsQ39023626
Computational analysis of associations between alternative splicing and histone modifications.Q39203932
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.Q39500409
Reciprocal intronic and exonic histone modification regions in humans.Q39634800
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways.Q40671579
Deep learning of the tissue-regulated splicing codeQ40749721
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectdeep learningQ197536
P304page(s)12100-12112
P577publication date2017-09-28
P1433published inNucleic Acids ResearchQ135122
P1476titleDeep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision
P478volume45

Reverse relations

cites work (P2860)
Q897928376mA-RicePred: A Method for Identifying DNA N 6-Methyladenine Sites in the Rice Genome Based on Feature Fusion
Q61813259A Novel Protein Subcellular Localization Method With CNN-XGBoost Model for Alzheimer's Disease
Q58740511Alternative splicing links histone modifications to stem cell fate decision
Q57486454Classifying Included and Excluded Exons in Exon Skipping Event Using Histone Modifications
Q89529812Computational Detection of Breast Cancer Invasiveness with DNA Methylation Biomarkers
Q92128043Convolutional Neural Network and Bidirectional Long Short-Term Memory-Based Method for Predicting Drug-Disease Associations
Q60949449Dual Convolutional Neural Network Based Method for Predicting Disease-Related miRNAs
Q64067898Dual Convolutional Neural Networks With Attention Mechanisms Based Method for Predicting Disease-Related lncRNA Genes
Q60582079Environmental influences on RNA processing: Biochemical, molecular and genetic regulators of cellular response
Q60915595Gene-Based Nonparametric Testing of Interactions Using Distance Correlation Coefficient in Case-Control Association Studies
Q93051882Gene2vec: gene subsequence embedding for prediction of mammalian N 6-methyladenosine sites from mRNA
Q64997830Meta-4mCpred: A Sequence-Based Meta-Predictor for Accurate DNA 4mC Site Prediction Using Effective Feature Representation.
Q64245824Predicting Ion Channels Genes and Their Types With Machine Learning Techniques
Q99237675Prediction of Anticancer Peptides Using a Low-Dimensional Feature Model
Q91884632Prospect of using deep learning for predicting differentiation of myeloid progenitor cells after sepsis
Q58761006RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis

Search more.