Epigenetics in alternative pre-mRNA splicing

scientific article

Epigenetics in alternative pre-mRNA splicing is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.CELL.2010.11.056
P3181OpenCitations bibliographic resource ID456670
P932PMC publication ID3038581
P698PubMed publication ID21215366
P5875ResearchGate publication ID49737443

P50authorAlberto KornblihttQ5663204
Tom MisteliQ7816902
Mariano AllóQ55154498
P2093author name stringReini F Luco
Ignacio E Schor
P2860cites workHuman STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivoQ24291710
The human SWI/SNF subunit Brm is a regulator of alternative splicingQ24298527
Genome-scale DNA methylation maps of pluripotent and differentiated cellsQ24621431
Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cellsQ24811229
Alternative isoform regulation in human tissue transcriptomesQ27861118
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylationQ27937996
Transcriptional activators differ in their abilities to control alternative splicingQ28200998
Stimulatory effect of splicing factors on transcriptional elongationQ28214807
The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2CQ28287199
Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tailQ28297786
The C-terminal domain of RNA polymerase II couples mRNA processing to transcriptionQ28301744
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.Q28582631
5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase IIQ28623635
An extensive network of coupling among gene expression machinesQ29547273
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencingQ29547470
RNA polymerase II is an essential mRNA polyadenylation factorQ29614773
Pre-mRNA processing reaches back to transcription and ahead to translationQ29615045
RNA and diseaseQ29615183
The SR protein family of splicing factors: master regulators of gene expressionQ29619935
Splice site selection, rate of splicing, and alternative splicing on nascent transcriptsQ30461752
Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patternsQ33241167
Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence.Q33342855
Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assemblyQ33510906
Complex exon-intron marking by histone modifications is not determined solely by nucleosome distributionQ33680184
First come, first served revisited: factors affecting the same alternative splicing event have different effects on the relative rates of intron removalQ33799119
Deciphering the splicing codeQ34022324
Regulation of alternative splicing by histone modificationsQ34035543
Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicingQ34082987
The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally splicedQ34308679
T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear exportQ34364453
Nova regulates brain-specific splicing to shape the synapseQ34436585
Alternative splicing: multiple control mechanisms and involvement in human diseaseQ34586931
Functional coupling of RNAP II transcription to spliceosome assemblyQ34650438
A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptionalQ35688363
Influence of RNA secondary structure on the pre-mRNA splicing processQ35968217
Promoter usage and alternative splicingQ36131493
Nucleosome positioning as a determinant of exon recognitionQ46849980
A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing.Q47070600
SR protein family members display diverse activities in the formation of nascent and mature mRNPs in vivo.Q47942040
Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex.Q50336085
Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription.Q52544550
The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.Q53577978
ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genomeQ57020086
Chromatin organization marks exon-intron structureQ57058000
Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?Q58830817
Outcome of donor splice site mutations accounting for congenital afibrinogenemia reflects order of intron removal in the fibrinogen alpha gene (FGA)Q60656407
RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivoQ77962891
Promoter architecture modulates CFTR exon 9 skippingQ78488641
Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cellsQ80143464
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factorsQ36233711
Functional association between promoter structure and transcript alternative splicing.Q36597450
Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genesQ36601454
Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA.Q36823565
Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promotersQ36885592
Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylationQ36922600
The splicing factor SC35 has an active role in transcriptional elongationQ36952048
Splice-site pairing is an intrinsically high fidelity process.Q37100836
Differential chromatin marking of introns and expressed exons by H3K36me3.Q37111430
Searching for splicing motifs.Q37124812
Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing.Q37132771
Co-transcriptional splicing of constitutive and alternative exonsQ37344492
Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAsQ37352034
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencingQ37363149
Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II.Q37417788
Regulation of alternative splicing by short non-coding nuclear RNAsQ37775454
Functional diversity of the hnRNPs: past, present and perspectivesQ37783316
Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancerQ38320513
SWI/SNF associates with nascent pre-mRNPs and regulates alternative pre-mRNA processingQ38510244
Co-transcriptional commitment to alternative splice site selection.Q39726004
Cotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeastQ39793431
DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.Q39850003
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeastQ39895202
RNA polymerase II carboxy-terminal domain phosphorylation is required for cotranscriptional pre-mRNA splicing and 3'-end formationQ40025884
SR proteins function in coupling RNAP II transcription to pre-mRNA splicing.Q40115980
RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20.Q40222409
CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicingQ40376847
Coactivator-associated arginine methyltransferase 1, CARM1, affects pre-mRNA splicing in an isoform-specific mannerQ40412216
A slow RNA polymerase II affects alternative splicing in vivoQ40627617
Splicing precedes polyadenylation during Drosophila E74A transcriptionQ40640692
Role of RNA polymerase II carboxy-terminal domain in coordinating transcription with RNA processingQ40945481
A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genomeQ41336121
Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeastQ41355869
Nucleosomes are well positioned in exons and carry characteristic histone modificationsQ41863525
Concurrent splicing and transcription are not sufficient to enhance splicing efficiencyQ41936701
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in DrosophilaQ41951844
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicingQ41999449
Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae.Q42038332
Relationship between nucleosome positioning and DNA methylationQ42151152
Biased chromatin signatures around polyadenylation sites and exonsQ42689954
Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylationQ43147112
The Gcn5 bromodomain of the SAGA complex facilitates cooperative and cross-tail acetylation of nucleosomesQ43148421
Nucleosomes are preferentially positioned at exons in somatic and sperm cellsQ43262911
Coordinate regulation of transcription and splicing by steroid receptor coregulatorsQ44177314
Control of alternative splicing through siRNA-mediated transcriptional gene silencing.Q45960034
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectepigeneticsQ26939
P304page(s)16-26
P577publication date2011-01-07
P1433published inCellQ655814
P1476titleEpigenetics in alternative pre-mRNA splicing
P478volume144

Reverse relations

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Q46107885Overexpression of Histone Deacetylase and Amyloid Precursor Protein in Hepatocellular Carcinoma
Q27312184Oxidative Stress Triggers Body-Wide Skipping of Multiple Exons of the Spinal Muscular Atrophy Gene
Q34970694PGC1α -1 Nucleosome Position and Splice Variant Expression and Cardiovascular Disease Risk in Overweight and Obese Individuals
Q36023229POF regulates the expression of genes on the fourth chromosome in Drosophila melanogaster by binding to nascent RNA
Q98906690Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network
Q36754746Patterning and regulatory associations of DNA methylation are mirrored by histone modifications in insects
Q45348850Persistent detection of alternatively spliced BCR-ABL variant results in a failure to achieve deep molecular response
Q27313223Perturbation of chromatin structure globally affects localization and recruitment of splicing factors
Q47102643Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells
Q41880113Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.
Q90429642Plasmid-based gap-repair recombineered transgenes reveal a central role for introns in mutually exclusive alternative splicing in Down Syndrome Cell Adhesion Molecule exon 4
Q42212098Polyadenylation of Friend murine leukemia virus env-mRNA is affected by its splicing
Q55279279Position-specific intron retention is mediated by the histone methyltransferase SDG725.
Q36398266Post-transcriptional regulation in cancer progression : Microenvironmental control of alternative splicing and translation
Q37621927Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia
Q36194662Pre-mRNA Processing Factor Prp18 Is a Stimulatory Factor of Influenza Virus RNA Synthesis and Possesses Nucleoprotein Chaperone Activity
Q34551455Pre-mRNA splicing is a determinant of nucleosome organization
Q37868141Pre-mRNA splicing: where and when in the nucleus
Q37078868Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
Q34276472Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing
Q34579243Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs
Q29620033RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
Q38852154RNA Dynamics in the Control of Circadian Rhythm
Q50645951RNA Pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD Phosphorylation, and Transcriptional Direction.
Q41940904RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing
Q33858687RNA Splicing Factors and RNA-Directed DNA Methylation.
Q40884810RNA driving the epigenetic bus.
Q37997897RNA polymerase II transcription on the fast lane
Q37391660RNA splicing factors as oncoproteins and tumour suppressors
Q38155497RNA splicing: a new player in the DNA damage response
Q37882854RNA splicing: disease and therapy
Q34284546RNA-Seq and human complex diseases: recent accomplishments and future perspectives.
Q47704101RNA-seq analysis reveals alternative splicing under salt stress in cotton, Gossypium davidsonii
Q88683864Rapid and Dynamic Alternative Splicing Impacts the Arabidopsis Cold Response Transcriptome
Q64055999Recent advances in the characterization of plant transcriptomes in response to drought, salinity, heat, and cold stress
Q26863751Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
Q34999412Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention
Q52836988Regional DNA methylation differences between humans and chimpanzees are associated with genetic changes, transcriptional divergence and disease genes.
Q26861955Regulated pre-mRNA splicing: the ghostwriter of the eukaryotic genome
Q48946249Regulating mRNA complexity in the mammalian brain.
Q91786756Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome
Q38949799Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5' splice site selection
Q38858919Regulation of Tissue-Specific Alternative Splicing: C. elegans as a Model System
Q26999239Regulation of alternative splicing by local histone modifications: potential roles for RNA-guided mechanisms
Q38324240Regulation of alternative splicing by the circadian clock and food related cues
Q37648778Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain
Q38092678Regulation of splicing by SR proteins and SR protein-specific kinases
Q37684657Regulatory landscape and clinical implication of MBD3 in human malignant glioma.
Q35113558Relationship between nucleosome positioning and progesterone-induced alternative splicing in breast cancer cells
Q55003080Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines.
Q36060128Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease.
Q42555454Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors
Q24298821SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing
Q39115667SR Proteins: Binders, Regulators, and Connectors of RNA.
Q34065060SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster
Q34294075Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system
Q35100314Sex determination in insects: a binary decision based on alternative splicing.
Q61443584Sexual dimorphism in brain transcriptomes of Amami spiny rats (Tokudaia osimensis): a rodent species where males lack the Y chromosome
Q58560872Short and narrow flag leaf1, a GATA zinc finger domain-containing protein, regulates flag leaf size in rice (Oryza sativa)
Q26765946Small RNAs: essential regulators of gene expression and defenses against environmental stresses in plants
Q35672134Son maintains accurate splicing for a subset of human pre-mRNAs
Q38008396Spatial Organization and Dynamics of Transcription Elongation and Pre-mRNA Processing in Live Cells.
Q27006500Splice isoforms as therapeutic targets for colorectal cancer
Q42106564SpliceAid-F: a database of human splicing factors and their RNA-binding sites
Q36967122Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome
Q26798148Splicing Regulation: A Molecular Device to Enhance Cancer Cell Adaptation
Q39500409Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.
Q38187632Splicing factor mutations and cancer
Q39999542Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II.
Q35113616Splicing of designer exons informs a biophysical model for exon definition
Q42095047Splicing of many human genes involves sites embedded within introns
Q50098862Splicing regulation by long noncoding RNAs.
Q28593622Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness
Q58093155Statistical inference of the rate of RNA polymerase II elongation by total RNA sequencing
Q35113601Stress-induced endogenous siRNAs targeting regulatory intron sequences in Brachypodium.
Q42071505Switch-like regulation of tissue-specific alternative pre-mRNA processing patterns revealed by customized fluorescence reporters
Q36263400Systematic Mapping of RNA-Chromatin Interactions In Vivo.
Q35212538Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators
Q35133477TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome
Q40871398TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription.
Q43206259TINTIN, at the interface of chromatin, transcription elongation, and mRNA processing
Q99418746Targeting the epigenetic regulation of antitumour immunity
Q30557271The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.
Q47221632The Importance of ncRNAs as Epigenetic Mechanisms in Phenotypic Variation and Organic Evolution
Q57491556The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism
Q26747254The Metabolic Impact on Histone Acetylation and Transcription in Ageing
Q34303212The RNA polymerase II CTD coordinates transcription and RNA processing.
Q37138675The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease
Q36197666The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing
Q44398735The cell biology of genomes: bringing the double helix to life.
Q37873983The central role of RNA in human development and cognition
Q38679766The determinants of alternative RNA splicing in human cells.
Q34342920The exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript.
Q50753040The function of intragenic DNA methylation: insights from insect epigenomes.
Q38172436The functional consequences of intron retention: alternative splicing coupled to NMD as a regulator of gene expression
Q90006424The importance of DNA methylation of exons on alternative splicing
Q52719643The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes.
Q35074663The nucleosome regulates the usage of polyadenylation sites in the human genome
Q36410173The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches
Q42282317The role of alternative splicing in cancer
Q38239862The role of chromatin dynamics in immune cell development
Q36227863The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing
Q38057608The spliceosome as a target of novel antitumour drugs
Q35970320The spliceosome-activating complex: molecular mechanisms underlying the function of a pleiotropic regulator
Q35671874The trajectory of life. Decreasing physiological network complexity through changing fractal patterns
Q39787845The translational landscape of the splicing factor SRSF1 and its role in mitosis.
Q30945159The variation game: Cracking complex genetic disorders with NGS and omics data
Q40150714There is a world beyond protein mutations: the role of non-coding RNAs in melanomagenesis
Q30553128Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion
Q35641934Tracking intron removal in real time
Q57331942Trans-Ethnic Mapping of Identifies Two Independent SLE-Risk Linkage Groups Enriched for Co-Transcriptional Splicing Marks
Q33556144Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop
Q42705161Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation
Q34162566Transcriptome analysis of the model protozoan, Tetrahymena thermophila, using Deep RNA sequencing
Q39733187Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing
Q43451548Transcriptome-wide expression variation associated with environmental plasticity and mating success in cactophilic Drosophila mojavensis
Q38958002Translational research in neuroendocrine tumors: pitfalls and opportunities
Q24297433USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing
Q91826178Understanding aberrant RNA splicing to facilitate cancer diagnosis and therapy
Q30866842Understanding gene regulatory mechanisms by integrating ChIP-seq and RNA-seq data: statistical solutions to biological problems
Q34354780Understanding the regulatory and transcriptional complexity of the genome through structure
Q43159836Unexpected selection to retain high GC content and splicing enhancers within exons of multiexonic lncRNA loci
Q41345618Unique role of SRSF2 in transcription activation and diverse functions of the SR and hnRNP proteins in gene expression regulation
Q37937061Unraveling the glioma epigenome: from molecular mechanisms to novel biomarkers and therapeutic targets
Q37978586Unscrambling genetic information at the RNA level
Q36642277Using an exon microarray to identify a global profile of gene expression and alternative splicing in K562 cells exposed to sodium valproate
Q91912219Using secondary structure to predict the effects of genetic variants on alternative splicing
Q38601979Variation in DNA Methylation Is Not Consistently Reflected by Sociality in Hymenoptera.
Q36587843Widespread RNA binding by chromatin-associated proteins
Q47208524Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells
Q52765902[Pre-mRNA splicing: when the spliceosome loses ground].
Q47103256cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition
Q30647275diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates
Q37424880mRNA changes in nucleus accumbens related to methamphetamine addiction in mice
Q51151318mRNA expression and DNA methylation in three key genes involved in caste differentiation in female honeybees (Apis mellifera).
Q30698709rSeqDiff: detecting differential isoform expression from RNA-Seq data using hierarchical likelihood ratio test

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