Rational drug design via intrinsically disordered protein

scientific article published on 28 July 2006

Rational drug design via intrinsically disordered protein is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.TIBTECH.2006.07.005
P698PubMed publication ID16876893

P50authorMarc CorteseQ55143871
Vladimir N. UverskyQ59698496
P2093author name stringPedro Romero
A Keith Dunker
Christopher J Oldfield
Yugong Cheng
Ya-Yue J Van
Tanguy LeGall
James P Mueller
P2860cites workBCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.Q33960826
P433issue10
P921main subjectprotein designQ410814
P304page(s)435-442
P577publication date2006-07-28
P1433published inTrends in BiotechnologyQ2451465
P1476titleRational drug design via intrinsically disordered protein
P478volume24

Reverse relations

cites work (P2860)
Q37088664A careful disorderliness in the proteome: sites for interaction and targets for future therapies.
Q35642431A complex task? Direct modulation of transcription factors with small molecules
Q28681184A decade and a half of protein intrinsic disorder: biology still waits for physics
Q33331025A new protein linear motif benchmark for multiple sequence alignment software
Q37421771A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
Q30358999Advantages of proteins being disordered.
Q41357989An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces
Q30377015An Overview of Practical Applications of Protein Disorder Prediction and Drive for Faster, More Accurate Predictions.
Q31122058An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome data
Q50979449Backbone and side-chain resonance assignments for the tmRNA-binding protein, SmpB, from Mycobacterium tuberculosis.
Q47900402Backbone conformational preferences of an intrinsically disordered protein in solution.
Q35571730Binding cavities and druggability of intrinsically disordered proteins
Q37653031Bioinformatical approaches to characterize intrinsically disordered/unstructured proteins
Q37103616Cell-division inhibitors: new insights for future antibiotics
Q34787399Characterization of the interactions between the nucleoprotein and the phosphoprotein of Henipavirus
Q39356263Comprehensive review of methods for prediction of intrinsic disorder and its molecular functions
Q87190843Conformational stability of PCID2 upon DSS1 binding with molecular dynamics simulation
Q92932799Conservation of Potentially Druggable Cavities in Intrinsically Disordered Proteins
Q27653453Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
Q30456084DNdisorder: predicting protein disorder using boosting and deep networks
Q52593130Deciphering the dark proteome of Chikungunya virus.
Q37739405DisBind: A database of classified functional binding sites in disordered and structured regions of intrinsically disordered proteins
Q28550591DisPredict: A Predictor of Disordered Protein Using Optimized RBF Kernel
Q30376073Disorder-to-order conformational transitions in protein structure and its relationship to disease.
Q33814963Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions
Q41865629Drug Targeting of alpha-Synuclein Oligomerization in Synucleinopathies
Q35781398Druggability of Intrinsically Disordered Proteins
Q36071932Dynamical coupling of intrinsically disordered proteins and their hydration water: comparison with folded soluble and membrane proteins
Q42177256Dynamics of the intrinsically disordered C-terminal domain of the nipah virus nucleoprotein and interaction with the x domain of the phosphoprotein as unveiled by NMR spectroscopy
Q30010028Engineering of an elastic scaffolding polyprotein based on an SH3-binding intrinsically disordered titin PEVK module
Q29048164Evaluation of disorder predictions in CASP9
Q34197530Expanding the proteome: disordered and alternatively folded proteins
Q41220497Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding
Q37855889Finding order within disorder: elucidating the structure of proteins associated with neurodegenerative disease
Q28478955HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization
Q28541113High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor
Q38732930How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication
Q37951586How random are intrinsically disordered proteins? A small angle scattering perspective
Q38089151How to design multi-target drugs.
Q37557811Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma
Q64097123Identification of a novel potassium channel (GiK) as a potential drug target in : Computational descriptions of binding sites
Q35585498Identification of inhibitors of biological interactions involving intrinsically disordered proteins
Q41015632Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide
Q36554344Inherent relationships among different biophysical prediction methods for intrinsically disordered proteins
Q50559158Intrinsic Disorder and Semi-disorder Prediction by SPINE-D.
Q34594105Intrinsic disorder in scaffold proteins: getting more from less
Q35044139Intrinsic disorder mediates hepatitis C virus core-host cell protein interactions.
Q33514873Intrinsic structural disorder confers cellular viability on oncogenic fusion proteins
Q27926249Intrinsically Disordered Side of the Zika Virus Proteome
Q38007557Intrinsically disordered proteins and novel strategies for drug discovery
Q35510300Intrinsically disordered proteins in cellular signalling and regulation.
Q21560973Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations
Q28534062Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins
Q34688655Marked variability in the extent of protein disorder within and between viral families
Q28477146Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP
Q38669148Methods of probing the interactions between small molecules and disordered proteins
Q27313374Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response
Q64087496Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies
Q38453820Molecular recognition features (MoRFs) in three domains of life
Q38533275Multiscale ensemble modeling of intrinsically disordered proteins: p53 N-terminal domain
Q38198240NMR contributions to structural dynamics studies of intrinsically disordered proteins
Q37891686Novel strategies for drug discovery based on Intrinsically Disordered Proteins (IDPs)
Q45965349POODLE-L: a two-level SVM prediction system for reliably predicting long disordered regions.
Q33909288Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases
Q21145360Prediction of protein binding regions in disordered proteins
Q37030888Privileged scaffolds targeting reverse-turn and helix recognition.
Q26801512Protein Folding and Mechanisms of Proteostasis
Q30456527Protein crystallization in drug design: towards a rational approach
Q37862224Protein-protein interactions: principles, techniques, and their potential role in new drug development
Q28479221Proteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosis
Q33318734REDCRAFT: a tool for simultaneous characterization of protein backbone structure and motion from RDC data
Q64945196Recent Advances in Computational Protocols Addressing Intrinsically Disordered Proteins.
Q37324058Redefining the BH3 Death Domain as a 'Short Linear Motif'.
Q38218411Retrospective on the all-in-one retroviral nucleocapsid protein
Q91708289Sequence-Derived Markers of Drug Targets and Potentially Druggable Human Proteins
Q39295360Small molecule screening identifies regulators of the transcription factor ΔFosB
Q27025648Small-molecule inhibitors of the Myc oncoprotein
Q51362509Stochastic simulation of structural properties of natively unfolded and denatured proteins.
Q35902551Structural Disorder within Paramyxoviral Nucleoproteins and Phosphoproteins in Their Free and Bound Forms: From Predictions to Experimental Assessment
Q47094704Structural analysis of the complex between influenza B nucleoprotein and human importin-α.
Q33640276Structural disorder within Henipavirus nucleoprotein and phosphoprotein: from predictions to experimental assessment
Q38005681Structure of metabotropic glutamate receptor C-terminal domains in contact with interacting proteins
Q36638977Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc
Q36020398Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept
Q35835558Targeting intrinsically disordered proteins in rational drug discovery
Q27348831Targeting protein-protein interactions for parasite control
Q27651262The NMR structures of the major intermediates of the two-domain tick carboxypeptidase inhibitor reveal symmetry in its folding and unfolding pathways
Q56978719The Rational Discovery of a Tau Aggregation Inhibitor
Q36379177The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations
Q37347480The retinal cGMP phosphodiesterase gamma-subunit - a chameleon
Q42174981The role of intrinsically unstructured proteins in neurodegenerative diseases
Q38481133The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting.
Q30372413The unfoldomics decade: an update on intrinsically disordered proteins.
Q27021480The universally conserved prokaryotic GTPases
Q38806231Therapeutic Interventions of Cancers Using Intrinsically Disordered Proteins as Drug Targets: c-Myc as Model System.
Q30385084Understanding protein non-folding.
Q30155273VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B.
Q24567790pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins

Search more.