Resveratrol Downregulates Biomarkers of Sepsis via Inhibition of Proteasome's Proteases

scientific article published on 13 December 2017

Resveratrol Downregulates Biomarkers of Sepsis via Inhibition of Proteasome's Proteases is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1097/SHK.0000000000001080
P932PMC publication ID5999526
P698PubMed publication ID29240645

P50authorNeerupma SilswalQ59707666
P2093author name stringNilofer Qureshi
Asaf A Qureshi
Nidhi S Reddy
P2860cites workLPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIFQ24672442
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)Q26768286
The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling eventsQ28594630
Interferon-gamma inducible exchanges of 20S proteasome active site subunits: why?Q34214158
Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trialsQ34415123
Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life spanQ34820212
Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental modelsQ35505150
CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin toleranceQ35845957
Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitorQ36086859
Proteasome protease mediated regulation of cytokine induction and inflammationQ36301130
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myelomaQ36384889
Complete structural determination of lipopolysaccharide obtained from deep rough mutant of Escherichia coli. Purification by high performance liquid chromatography and direct analysis by plasma desorption mass spectrometryQ36433739
Bioavailability and safety study of resveratrol 500 mg tablets in healthy male and female volunteersQ36502078
20S proteasome and its inhibitors: crystallographic knowledge for drug developmentQ36742369
Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implicationsQ36979669
A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock modelQ37151518
Nutritional Supplement-5 with a Combination of Proteasome Inhibitors (Resveratrol, Quercetin, δ-Tocotrienol) Modulate Age-Associated Biomarkers and Cardiovascular Lipid Parameters in Human SubjectsQ37364057
Endotoxin tolerance: new mechanisms, molecules and clinical significanceQ37603612
Small molecule SIRT1 activators for the treatment of aging and age-related diseasesQ37673310
Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular diseaseQ37831940
Inhibitors for the immuno- and constitutive proteasome: current and future trends in drug developmentQ38019864
The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancerQ38087182
Sepsis Up-Regulates CD14 Expression in a MyD88 Dependent and Trif Independent PathwayQ38754037
Resveratrol reduces the proinflammatory effects and lipopolysaccharide- induced expression of HMGB1 and TLR4 in RAW264.7 cellsQ38997831
Impact of wines and wine constituents on cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase catalytic activity.Q39153607
Protective effect of resveratrol against endotoxemia-induced lung injury involves the reduction of oxidative/nitrative stressQ42709995
PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivoQ42821645
Sepsis: redox mechanisms and therapeutic opportunitiesQ43203144
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.Q45969598
Resveratrol reduces renal and lung injury caused by sepsis in ratsQ46952282
Of Mice and Men: Proteasome's Role in LPS-Induced Inflammation and Tolerance.Q53720678
Key inflammatory signaling pathways are regulated by the proteasomeQ83298977
Human monocytes produce interferon-gamma upon stimulation with LPSQ87552501
P921main subjectsepsisQ183134
biomarkerQ864574
P577publication date2017-12-13
P1433published inShockQ7499831
P1476titleResveratrol Downregulates Biomarkers of Sepsis via Inhibition of Proteasome's Proteases

Reverse relations

Q64078780Challenge to the Intestinal Mucosa During Sepsiscites workP2860

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