Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

scientific article

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1100179085
P356DOI10.1038/S41598-017-18468-7
P932PMC publication ID5760655
P698PubMed publication ID29317705

P50authorThomas F. MeyerQ2423758
Andreas NerlichQ56958081
Martin WitzenrathQ56961541
P2093author name stringNorbert Suttorp
Maren Mieth
Jens Neudecker
Torsten T Bauer
Timothy J Mitchell
Eleftheria Letsiou
Andreas C Hocke
Diana Fatykhova
Maria Schimek
Paul Schneider
Stefan Hippenstiel
Stephan Eggeling
Jens C Rückert
Katja Zscheppang
Aki Imai-Matsushima
Lisa Paasch
Mario Tönnies
P2860cites workRole of pneumolysin for the development of acute lung injury in pneumococcal pneumonia.Q51804034
The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal PneumoniaQ58286289
Expression of the pneumolysin gene in Escherichia coli: rapid purification and biological propertiesQ69481233
Community-acquired pneumoniaQ86937026
Molecular characterization of mitochondrial apoptosis-inducing factorQ22001452
Mitochondrial DNA stress primes the antiviral innate immune responseQ23030015
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic AcidQ27316130
Cardiotoxicity during invasive pneumococcal diseaseQ28081769
Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport.Q28362214
Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosisQ28537654
Mitochondrial DNA fragments released through the permeability transition pore correspond to specific gene sizeQ28566516
Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitisQ28568567
Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validationQ28660920
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasomeQ29547419
Circulating mitochondrial DAMPs cause inflammatory responses to injuryQ29614470
Helicobacter pylori VacA toxin/subunit p34: targeting of an anion channel to the inner mitochondrial membraneQ30156876
The cholesterol-dependent cytolysin family of gram-positive bacterial toxins.Q30156934
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.Q30353189
Listeria monocytogenes transiently alters mitochondrial dynamics during infectionQ30498309
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.Q33750041
Necroptosis: the release of damage-associated molecular patterns and its physiological relevanceQ34035754
Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase.Q34177160
Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ effluxQ35206149
Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle sheddingQ35207653
Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.Q35343578
Interplay between mitochondria and cellular calcium signallingQ35672374
Calcium signalling during cell interactions with bacterial pathogensQ35749180
Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung TissueQ35758711
ATP Depletion Via Mitochondrial F1F0 Complex by Lethal Factor is an Early Event in B. Anthracis-Induced Sudden Cell DeathQ35760558
Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial PneumoniaQ35867134
Mitochondrial DNA in the regulation of innate immune responsesQ36447892
Streptococcus pneumoniae: the role of apoptosis in host defense and pathogenesis.Q36537673
Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle ArrestQ36741309
Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.Q37310879
Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicatorsQ37327467
Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epitheliumQ37521398
Mitochondria in innate immunityQ37907827
Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injuryQ37973108
The biology of pneumolysinQ38209510
Determinants and functions of mitochondrial behaviorQ38257391
Microvesicles: ubiquitous contributors to infection and immunityQ38282835
Mitochondrial Ca2+ and regulation of the permeability transition poreQ38920740
Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and LysosomesQ38969543
Metabolic reprogramming & inflammation: Fuelling the host response to pathogens.Q38990670
The mitochondria-endoplasmic reticulum contact sites: a signalling platform for cell deathQ39229178
Mitochondrial DNA in innate immune responses and inflammatory pathology.Q39231387
Mitochondria are the powerhouses of immunity.Q39248031
Sensitivities of human monocytes and epithelial cells to pneumolysin are different.Q39653984
Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosisQ39697070
Tyk2 as a target for immune regulation in human viral/bacterial pneumoniaQ40123508
Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin.Q40374441
Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia: Prevention and reversal by intratracheal DNase I.Q40482050
Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attackQ40592086
Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.Q41740129
Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathwayQ41918257
Pneumolysin causes neuronal cell death through mitochondrial damageQ41960118
Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.Q43551075
C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transductionQ44968456
Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissueQ45288786
The mechanism of pneumolysin-induced cochlear hair cell death in the rat.Q46624496
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmitochondrial DNAQ27075
P304page(s)182
P577publication date2018-01-09
P1433published inScientific ReportsQ2261792
P1476titlePneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.
P478volume8

Reverse relations

cites work (P2860)
Q58579190Endothelial Extracellular Vesicles in Pulmonary Function and Disease
Q58799687Mechanical ventilation and Streptococcus pneumoniae pneumonia alter mitochondrial homeostasis
Q92661496Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity
Q61442975Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone
Q90734370Mitochondrial damage-associated molecular patterns released by lung transplants are associated with primary graft dysfunction
Q97883476Pneumolysin: Pathogenesis and Therapeutic Target
Q91730245Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly

Search more.