review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Rosario Rizzuto | Q41312267 |
P2093 | author name string | Anna Raffaello | |
Cristina Mammucari | |||
Gaia Gherardi | |||
P2860 | cites work | MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter | Q41976396 |
NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. | Q42489294 | ||
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors | Q42917771 | ||
A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability. | Q42985705 | ||
Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor | Q43002260 | ||
Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart | Q43099248 | ||
Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart | Q43569071 | ||
pH-dependent regulation of lysosomal calcium in macrophages | Q43893449 | ||
Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). | Q44285317 | ||
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling | Q44468436 | ||
The effect of pH on rate constants, ion selectivity and thermodynamic properties of fluorescent calcium and magnesium indicators | Q44956277 | ||
Chaperone-mediated autophagy is defective in mucolipidosis type IV. | Q46178880 | ||
Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes. | Q46387081 | ||
Nicotinic acid adenine dinucleotide phosphate triggers Ca2+ release from brain microsomes | Q48152597 | ||
A novel Ca²⁺-mediated cross-talk between endoplasmic reticulum and acidic organelles: implications for NAADP-dependent Ca²⁺ signalling | Q48342353 | ||
Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release | Q48601633 | ||
The role of calcium in the regulation of mitochondrial metabolism | Q50337229 | ||
NAADP mobilizes calcium from the endoplasmic reticular Ca(2+) store in T-lymphocytes. | Q50698075 | ||
Identification of the gene causing mucolipidosis type IV. | Q52165526 | ||
Acidic Ca(2+) stores come to the fore | Q83879499 | ||
MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake | Q24294670 | ||
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival | Q24301822 | ||
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter | Q24306825 | ||
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter | Q24306850 | ||
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition | Q24307004 | ||
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state | Q24315101 | ||
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake | Q24336668 | ||
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity | Q24338031 | ||
EMRE is an essential component of the mitochondrial calcium uniporter complex | Q24339589 | ||
The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase | Q26749074 | ||
Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors | Q26852168 | ||
Architecture and conformational switch mechanism of the ryanodine receptor | Q27696307 | ||
CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter | Q27938400 | ||
Diseases caused by mutations in ORAI1 and STIM1 | Q28082032 | ||
Structure and function of the mitochondrial calcium uniporter complex | Q28083196 | ||
Two-pore channels at the intersection of endolysosomal membrane traffic | Q28085768 | ||
TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel | Q28115558 | ||
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex | Q28115674 | ||
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics | Q28116180 | ||
Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells. | Q39163399 | ||
Questioning regulation of two-pore channels by NAADP | Q39515801 | ||
Analysis of the structure and function of EMRE in a yeast expression system | Q39899817 | ||
Structural basis of mitochondrial tethering by mitofusin complexes. | Q40527845 | ||
Hormone-induced calcium oscillations depend on cross-coupling with inositol 1,4,5-trisphosphate oscillations | Q41747572 | ||
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition | Q41822328 | ||
Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca2+ from a thapsigargin-insensitive pool | Q41865560 | ||
EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. | Q41889367 | ||
MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter | Q28116907 | ||
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake | Q28118964 | ||
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells | Q28138792 | ||
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs | Q28216586 | ||
Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles | Q28286984 | ||
Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate | Q28299232 | ||
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose | Q28306365 | ||
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling | Q28486060 | ||
A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle | Q28588509 | ||
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit | Q28591017 | ||
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses | Q29616076 | ||
Mitofusin 2 tethers endoplasmic reticulum to mitochondria | Q29619861 | ||
Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum. | Q30537868 | ||
Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution | Q30621055 | ||
The voltage-gated sodium channel TPC1 confers endolysosomal excitability. | Q30810815 | ||
Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival | Q33573447 | ||
Reconstitution of the mitochondrial calcium uniporter in yeast | Q33790020 | ||
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria | Q33890261 | ||
TRP channels of intracellular membranes | Q34001734 | ||
NAADP receptors | Q34147867 | ||
Signals from the lysosome: a control centre for cellular clearance and energy metabolism | Q34340780 | ||
Unresolved questions from the analysis of mice lacking MCU expression | Q34425694 | ||
Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study | Q34431034 | ||
Structure of a mammalian ryanodine receptor | Q34451822 | ||
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium | Q34866369 | ||
Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment | Q35116100 | ||
Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors | Q35116636 | ||
The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo | Q35152163 | ||
Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface | Q35226850 | ||
The mitochondrial uniporter controls fight or flight heart rate increases. | Q35438927 | ||
Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling | Q35567148 | ||
Store-operated calcium entry: Mechanisms and modulation | Q35638530 | ||
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation | Q35742842 | ||
The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart | Q35836414 | ||
Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. | Q35895526 | ||
Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter | Q35931470 | ||
Gene expression changes of single skeletal muscle fibers in response to modulation of the mitochondrial calcium uniporter (MCU). | Q36094384 | ||
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. | Q36146320 | ||
Physiological and pathological roles of the mitochondrial permeability transition pore in the heart | Q36193286 | ||
Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter | Q36327478 | ||
Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25 | Q36518486 | ||
Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs | Q36650244 | ||
MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. | Q36675219 | ||
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. | Q36709792 | ||
Gating machinery of InsP3R channels revealed by electron cryomicroscopy | Q36721050 | ||
Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition | Q36770526 | ||
Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood | Q36794081 | ||
Autophagic dysfunction in mucolipidosis type IV patients | Q36835710 | ||
Lysosomes: fusion and function | Q36885390 | ||
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α. | Q36895350 | ||
Architecture of the mitochondrial calcium uniporter | Q36922063 | ||
TRPMLs: in sickness and in health | Q37216903 | ||
Activity of the mitochondrial calcium uniporter varies greatly between tissues | Q37281674 | ||
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. | Q37366133 | ||
High-throughput discovery of novel developmental phenotypes | Q37629635 | ||
MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload | Q37651609 | ||
Intracellular Ca2+ storage in health and disease: a dynamic equilibrium. | Q37699891 | ||
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter | Q37707538 | ||
Core myopathies | Q37968743 | ||
NAADP on target | Q37997679 | ||
Mitochondria as sensors and regulators of calcium signalling | Q38031124 | ||
The endoplasmic reticulum-mitochondria connection: one touch, multiple functions. | Q38161252 | ||
A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells | Q38275522 | ||
Coupling acidic organelles with the ER through Ca²⁺ microdomains at membrane contact sites. | Q38417593 | ||
Lysosomal calcium regulates autophagy. | Q38497949 | ||
The molecular era of the mitochondrial calcium uniporter | Q38569106 | ||
Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter | Q38770332 | ||
Mitochondrial Ca²⁺ uniporter is critical for store-operated Ca²⁺ entry-dependent breast cancer cell migration. | Q38914237 | ||
P433 | issue | 12 | |
P921 | main subject | endoplasmic reticulum | Q79927 |
P1104 | number of pages | 15 | |
P304 | page(s) | 1035-1049 | |
P577 | publication date | 2016-09-28 | |
P1433 | published in | Trends in Biochemical Sciences | Q1565711 |
P1476 | title | Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes | |
P478 | volume | 41 |
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