Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

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Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.TIBS.2016.09.001
P932PMC publication ID5123979
P698PubMed publication ID27692849

P50authorRosario RizzutoQ41312267
P2093author name stringAnna Raffaello
Cristina Mammucari
Gaia Gherardi
P2860cites workMICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporterQ41976396
NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area.Q42489294
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptorsQ42917771
A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability.Q42985705
Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptorQ43002260
Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the HeartQ43099248
Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heartQ43569071
pH-dependent regulation of lysosomal calcium in macrophagesQ43893449
Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).Q44285317
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signalingQ44468436
The effect of pH on rate constants, ion selectivity and thermodynamic properties of fluorescent calcium and magnesium indicatorsQ44956277
Chaperone-mediated autophagy is defective in mucolipidosis type IV.Q46178880
Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes.Q46387081
Nicotinic acid adenine dinucleotide phosphate triggers Ca2+ release from brain microsomesQ48152597
A novel Ca²⁺-mediated cross-talk between endoplasmic reticulum and acidic organelles: implications for NAADP-dependent Ca²⁺ signallingQ48342353
Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ releaseQ48601633
The role of calcium in the regulation of mitochondrial metabolismQ50337229
NAADP mobilizes calcium from the endoplasmic reticular Ca(2+) store in T-lymphocytes.Q50698075
Identification of the gene causing mucolipidosis type IV.Q52165526
Acidic Ca(2+) stores come to the foreQ83879499
MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptakeQ24294670
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survivalQ24301822
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporterQ24306825
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporterQ24306850
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionQ24307004
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic stateQ24315101
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptakeQ24336668
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activityQ24338031
EMRE is an essential component of the mitochondrial calcium uniporter complexQ24339589
The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP SynthaseQ26749074
Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptorsQ26852168
Architecture and conformational switch mechanism of the ryanodine receptorQ27696307
CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporterQ27938400
Diseases caused by mutations in ORAI1 and STIM1Q28082032
Structure and function of the mitochondrial calcium uniporter complexQ28083196
Two-pore channels at the intersection of endolysosomal membrane trafficQ28085768
TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) ChannelQ28115558
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complexQ28115674
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial BioenergeticsQ28116180
Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells.Q39163399
Questioning regulation of two-pore channels by NAADPQ39515801
Analysis of the structure and function of EMRE in a yeast expression systemQ39899817
Structural basis of mitochondrial tethering by mitofusin complexes.Q40527845
Hormone-induced calcium oscillations depend on cross-coupling with inositol 1,4,5-trisphosphate oscillationsQ41747572
The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability TransitionQ41822328
Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca2+ from a thapsigargin-insensitive poolQ41865560
EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.Q41889367
MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium UniporterQ28116907
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) UptakeQ28118964
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cellsQ28138792
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggsQ28216586
Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organellesQ28286984
Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphateQ28299232
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-riboseQ28306365
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handlingQ28486060
A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscleQ28588509
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunitQ28591017
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responsesQ29616076
Mitofusin 2 tethers endoplasmic reticulum to mitochondriaQ29619861
Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.Q30537868
Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolutionQ30621055
The voltage-gated sodium channel TPC1 confers endolysosomal excitability.Q30810815
Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survivalQ33573447
Reconstitution of the mitochondrial calcium uniporter in yeastQ33790020
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondriaQ33890261
TRP channels of intracellular membranesQ34001734
NAADP receptorsQ34147867
Signals from the lysosome: a control centre for cellular clearance and energy metabolismQ34340780
Unresolved questions from the analysis of mice lacking MCU expressionQ34425694
Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural studyQ34431034
Structure of a mammalian ryanodine receptorQ34451822
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calciumQ34866369
Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatmentQ35116100
Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptorsQ35116636
The mitochondrial calcium uniporter controls skeletal muscle trophism in vivoQ35152163
Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interfaceQ35226850
The mitochondrial uniporter controls fight or flight heart rate increases.Q35438927
Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria couplingQ35567148
Store-operated calcium entry: Mechanisms and modulationQ35638530
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activationQ35742842
The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the HeartQ35836414
Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.Q35895526
Assessment of cardiac function in mice lacking the mitochondrial calcium uniporterQ35931470
Gene expression changes of single skeletal muscle fibers in response to modulation of the mitochondrial calcium uniporter (MCU).Q36094384
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.Q36146320
Physiological and pathological roles of the mitochondrial permeability transition pore in the heartQ36193286
Structure and function of the N-terminal domain of the human mitochondrial calcium uniporterQ36327478
Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25Q36518486
Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor ConstructsQ36650244
MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.Q36675219
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.Q36709792
Gating machinery of InsP3R channels revealed by electron cryomicroscopyQ36721050
Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transitionQ36770526
Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhoodQ36794081
Autophagic dysfunction in mucolipidosis type IV patientsQ36835710
Lysosomes: fusion and functionQ36885390
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.Q36895350
Architecture of the mitochondrial calcium uniporterQ36922063
TRPMLs: in sickness and in healthQ37216903
Activity of the mitochondrial calcium uniporter varies greatly between tissuesQ37281674
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.Q37366133
High-throughput discovery of novel developmental phenotypesQ37629635
MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium OverloadQ37651609
Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.Q37699891
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporterQ37707538
Core myopathiesQ37968743
NAADP on targetQ37997679
Mitochondria as sensors and regulators of calcium signallingQ38031124
The endoplasmic reticulum-mitochondria connection: one touch, multiple functions.Q38161252
A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cellsQ38275522
Coupling acidic organelles with the ER through Ca²⁺ microdomains at membrane contact sites.Q38417593
Lysosomal calcium regulates autophagy.Q38497949
The molecular era of the mitochondrial calcium uniporterQ38569106
Molecular structure and pathophysiological roles of the Mitochondrial Calcium UniporterQ38770332
Mitochondrial Ca²⁺ uniporter is critical for store-operated Ca²⁺ entry-dependent breast cancer cell migration.Q38914237
P433issue12
P921main subjectendoplasmic reticulumQ79927
P1104number of pages15
P304page(s)1035-1049
P577publication date2016-09-28
P1433published inTrends in Biochemical SciencesQ1565711
P1476titleCalcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes
P478volume41

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cites work (P2860)
Q101166809A DNA-based voltmeter for organelles
Q47381756A novel fluorescent reporter detects plastic remodeling of mitochondria-ER contact sites
Q60046045A secretory pathway kinase regulates sarcoplasmic reticulum Ca homeostasis and protects against heart failure
Q58705909Activation of the Calcium-Sensing Receptor Corrects the Impaired Mitochondrial Energy Status Observed in Renal Polycystin-1 Knockdown Cells Modeling Autosomal Dominant Polycystic Kidney Disease
Q41928343Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis.
Q47942948Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer
Q89963647Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration
Q93042075Bok regulates mitochondrial fusion and morphology
Q90613869Calcium Dyshomeostasis and Lysosomal Ca2+ Dysfunction in Amyotrophic Lateral Sclerosis
Q90950194Calcium signalling in T cells
Q92238728Cored in the act: the use of models to understand core myopathies
Q92618656Crosstalk between Calcium and ROS in Pathophysiological Conditions
Q47981588Cryptococcal dissemination to the central nervous system requires the vacuolar calcium transporter Pmc1.
Q36297709Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage
Q92115399Emerging Principles of Selective ER Autophagy
Q99238081Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics
Q47943075Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).
Q88193971Endoplasmic Reticulum-Mitochondrial Contactology: Structure and Signaling Functions
Q90680400Excessive Accumulation of Ca2 + in Mitochondria of Y522S-RYR1 Knock-in Mice: A Link Between Leak From the Sarcoplasmic Reticulum and Altered Redox State
Q58803405Excitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson's and Other Neurodegenerative Diseases
Q55642082Expression patterns and genetic variation of the ovine skeletal muscle transcriptome of sheep from five Spanish meat breeds.
Q92070278Gestational Hypoxia and Programing of Lung Metabolism
Q46789730Human Cytomegalovirus UL111A and US27 gene products enhance the CXCL12/CXCR4 signaling axis via distinct mechanisms
Q88210359IP3 Receptor Properties and Function at Membrane Contact Sites
Q39446526IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer
Q92709398IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
Q40985734Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells
Q89075788Intracellular Ca2+ threshold reversibly switches flagellar beat off and on
Q94600774Klotho rewires cellular metabolism of breast cancer cells through alteration of calcium shuttling and mitochondrial activity
Q54976406LRRK2 and mitochondria: Recent advances and current views.
Q39287167Linking mitochondrial dysfunction to neurodegeneration in lysosomal storage diseases.
Q89623342Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer
Q47654998Lipids at membrane contact sites: cell signaling and ion transport.
Q47124126Lysosomal Calcium in Neurodegeneration
Q64102520Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla
Q89522894Mechanisms of Synergistic Interactions of Diabetes and Hypertension in Chronic Kidney Disease: Role of Mitochondrial Dysfunction and ER Stress
Q93221684Membrane transport proteins in melanosomes: Regulation of ions for pigmentation
Q47140527Mitochondria and Lysosomes: Discovering Bonds
Q46241903Mitochondrial Ca2+ transport in the endothelium: regulation by ions, redox signalling and mechanical forces.
Q39197373Mitochondrial Dysfunction in Airway Disease
Q91801764Mitochondrial Involvement in Cisplatin Resistance
Q92932334Mitochondrial dysfunction and its role in tissue-specific cellular stress
Q46289111Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models.
Q37639334Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges
Q91871195Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease
Q39299633New insights into the role of mitochondrial calcium homeostasis in cell migration
Q94569365Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
Q47661761Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.
Q89717496Post-treatment with Posiphen Reduces Endoplasmic Reticulum Stress and Neurodegeneration in Stroke Brain
Q92256683Priority Strategy of Intracellular Ca2+ Homeostasis in Skeletal Muscle Fibers During the Multiple Stresses of Hibernation
Q92926112Pyridine nucleotide regulation of hepatic endoplasmic reticulum calcium uptake
Q59804504Recent advances in the molecular mechanism of mitochondrial calcium uptake
Q90167443Recovirus NS1-2 Has Viroporin Activity That Induces Aberrant Cellular Calcium Signaling To Facilitate Virus Replication
Q59128094Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies
Q64076963Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging
Q52651095Release and uptake mechanisms of vesicular Ca2+ stores.
Q90368013Reliable measurement of free Ca2+ concentrations in the ER lumen using Mag-Fluo-4
Q54974646Ryanodine Receptors in Autophagy: Implications for Neurodegenerative Diseases?
Q46330392SERCA control of cell death and survival
Q60304737Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease
Q58596901Sensory neuropathy-causing mutations in ATL3 affect ER-mitochondria contact sites and impair axonal mitochondrial distribution
Q49795603Soluble Aβ1-42 increases the heterogeneity in synaptic vesicle pool size among synapses by suppressing intersynaptic vesicle sharing
Q91825267Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
Q59799237Subcellular connectomic analyses of energy networks in striated muscle
Q90573731Targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones
Q39199069The Upsides and Downsides of Organelle Interconnectivity
Q39225329The calcium-cancer signalling nexus.
Q58798770The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism
Q92336454USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance
Q89556571mPTP opening caused by Cdk5 loss is due to increased mitochondrial Ca2+ uptake

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