Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone

scientific article published in Scientific Reports

Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1111774510
P356DOI10.1038/S41598-018-37438-1
P932PMC publication ID6353918
P698PubMed publication ID30700745

P50authorKristen T RooneyQ58032469
P2093author name stringHeather W Stout-Delgado
Maria Plataki
Hua-Rong Huang
Soo Jung Cho
Ha Seon Yun
Rebecca M Harris
P2860cites workSerotype-specific mortality from invasive Streptococcus pneumoniae disease revisitedQ24803495
The maintenance of mitochondrial DNA integrity--critical analysis and updateQ26821907
Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status.Q54254423
Mitochondrial production of reactive oxygen species contributes to the β-adrenergic stimulation of mouse cardiomycytes.Q54597053
Agarose infiltration improves morphology of cryostat sections of lungQ71635690
Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial functionQ74180066
Immune response to influenza vaccination in a large healthy elderly populationQ74607919
Pneumonia and mortality in elderly patientsQ80475272
Pneumonia in the elderlyQ83460068
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species productionQ28139177
Antifibrotic activities of pirfenidone in animal modelsQ28239289
Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized ratsQ28536610
Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infectionQ28590924
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasomeQ29547419
The mitochondrial permeability transition pore and its role in cell deathQ29614183
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factorQ29619247
Calcium, ATP, and ROS: a mitochondrial love-hate triangleQ29619742
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosisQ29619852
Common infections in older adults.Q32001016
Mitochondria and ageing: role in heart, skeletal muscle and adipose tissueQ33813591
Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscleQ34488343
Mitochondria in innate immune responsesQ34799187
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature agingQ34919832
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesisQ35830162
Detection of a specific mitochondrial DNA deletion in tissues of older humansQ35891834
Mitochondria and ischemia-reperfusion injury of the heart: fixing a holeQ36404531
Immunosenescence of ageingQ36698262
Persistent damage induces mitochondrial DNA degradationQ36931213
Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjectsQ37604803
Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation.Q37608294
Detection and manipulation of mitochondrial reactive oxygen species in mammalian cellsQ37681100
Immune modulatory effects of the foodborne contaminant citrinin in miceQ39318366
The isolation and characterization of murine macrophagesQ39485692
Oxidative damage to mitochondrial DNA and its relationship to ageingQ40467350
Mitochondrial permeability transition pore and calcium handlingQ41931954
Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagyQ42224355
Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol.Q42528691
How can we improve the management and outcome of pneumonia in the elderly?Q43472043
Age-related changes in the immune response to influenza vaccination in a racially diverse, healthy elderly populationQ46308038
Effects of pirfenidone on the generation of reactive oxygen species in vitro.Q46898400
NLRP3 Inflammasome Activation in Aged Macrophages is diminished during Streptococcus pneumoniae InfectionQ47447801
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection.Q47569725
Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.Q47661761
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectStreptococcus pneumoniaeQ221179
P304page(s)971
P577publication date2019-01-30
P1433published inScientific ReportsQ2261792
P1476titleMitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone
P478volume9

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cites work (P2860)
Q92661496Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity
Q91730245Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly

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