Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

scientific article (publication date: December 2000)

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049529582
P356DOI10.1038/82565
P3181OpenCitations bibliographic resource ID1871046
P698PubMed publication ID11101840
P5875ResearchGate publication ID12225850

P50authorBruno MirouxQ55688178
Frédéric BouillaudQ33102384
P2093author name stringB S Manning
C Pecqueur
D Arsenijevic
D Richard
D Ricquier
E Couplan
H Onuma
M C Alves-Guerra
M Goubern
R Surwit
S Collins
S Raimbault
P2860cites workA simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by gamma-interferonQ50914324
Kupffer Cells Are a Dominant Site of Uncoupling Protein 2 Expression in Rat LiverQ59659362
Differential effect of L-histidine in human lymphocytes damaged by different oxygen radical producing systemsQ72073108
Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J miceQ72243308
A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generationQ73626811
Feed-Back Inhibition of Oxidative Stress by Oxidized Lipid/Amino Acid Reaction ProductsQ73940476
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemiaQ24324798
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCPQ24531899
Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 geneQ28139049
Energy metabolism in uncoupling protein 3 gene knockout miceQ28140746
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obeseQ28510931
Mitochondrial diseases in man and mouseQ29614555
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageQ29616101
Mitochondria and neuronal survivalQ33807218
Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control".Q33827415
Neurologic manifestations of toxoplasmosis in AIDS.Q33863820
Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.Q33951526
Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediatesQ36342907
Uncoupling: new approaches to an old problem of bioenergeticsQ41723090
Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2.Q42685139
A plant cold-induced uncoupling proteinQ48045241
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectoxygenQ629
reactive oxygen speciesQ424361
P304page(s)435-9
P577publication date2000-12-01
P1433published inNature GeneticsQ976454
P1476titleDisruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
P478volume26

Reverse relations

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Q34479176Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage
Q24294798Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
Q24541307Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production
Q33412998Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function
Q38104693Perspectives and potential applications of mitochondria-targeted antioxidants in cardiometabolic diseases and type 2 diabetes
Q38248841Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection
Q29620297Physiological Roles of Mitochondrial Reactive Oxygen Species
Q35683910Platelets from Asthmatic Individuals Show Less Reliance on Glycolysis
Q37354449Pleiotropic effects of negative energy balance in the postpartum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity
Q34525469Possible physiological roles of mitochondrial uncoupling proteins--UCPn
Q44936342Potassium channel openers are uncoupling protonophores: implication in cardioprotection.
Q92701983Presbycusis: An Update on Cochlear Mechanisms and Therapies
Q35878780Prevention of unloading-induced atrophy by vitamin E supplementation: links between oxidative stress and soleus muscle proteolysis?
Q44714805Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3.
Q35542184Prolactin, prolactin receptor and uncoupling proteins during fetal and neonatal development.
Q37021516Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase
Q41294400Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats
Q54958630Proteome-wide analysis of Anopheles culicifacies mosquito midgut: new insights into the mechanism of refractoriness
Q83870271Proton leak induced by reactive oxygen species produced during in vitro anoxia/reoxygenation in rat skeletal muscle mitochondria
Q90308514Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation - A novel concept
Q47666215Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy
Q34368892Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation
Q44969172Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle
Q91778275ROS and diseases: role in metabolism and energy supply
Q29615229ROS function in redox signaling and oxidative stress
Q33724561ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
Q51369263Rat liver uncoupling protein 2: Changes induced by a fructose-rich diet
Q44432045Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10.
Q53637322Redox Regulation of Apoptosis before and after Cytochrome C Release
Q33359505Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice
Q42775670Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation
Q43993754Regulation of cellular oncosis by uncoupling protein 2.
Q40670579Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase
Q40670574Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a prim
Q40321902Repetitive transient depolarizations of the inner mitochondrial membrane induced by proton pumping.
Q45038510Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondria
Q28570824Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway
Q49773776Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation
Q46328318Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk?
Q33872411Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice
Q35619170Role of UCP2 Expression after Hepatic Warm Ischemia-Reperfusion in the Rat
Q84704201Role of age and uncoupling protein-2 in oxidative stress, RAGE/AGE interaction and inflammatory liver injury
Q79738673Role of mitochondria in the immune response to cancer: a central role for Ca2+
Q37097807Role of mitochondrial dysfunction in insulin resistance
Q33795475Role of the transmembrane potential in the membrane proton leak.
Q36837997Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning
Q34008199Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.
Q37328314Role of uncoupling proteins in cancer
Q38004940Roles of Endoplasmic Reticulum and Energetic Stress in Disturbed Sleep
Q36081146Roles of mitochondrial energy dissipation systems in plant development and acclimation to stress
Q43192513SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity
Q47789118Selective detection of UCP 3 expression in skeletal muscle: effect of thyroid status and temperature acclimation
Q57420160Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition
Q33485224Sex differences in global mRNA content of human skeletal muscle
Q60566005Sex-Dependent Dietary Obesity, Induction of UCPs, and Leptin Expression in Rat Adipose Tissues
Q60660388Sexual dimorphism in age-related changes in UCP2 and leptin gene expression in subcutaneous adipose tissue in humans
Q38343859Short report: Tissue-specific expression profiles of the uncoupling protein family in normal control mice and genetically ob/ob mice
Q35609951Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions
Q24810302Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
Q28510836Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis
Q28488385Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2
Q37362943Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2
Q27470232Stealth and cunning: hepatitis B and hepatitis C viruses
Q51722977Studies of UCP2 transgenic and knockout mice reveal that liver UCP2 is not essential for the antiobesity effects of fish oil.
Q34404381Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring
Q35640693Superoxide Mediates Depressive Effects Induced by Hydrogen Sulfide in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats
Q28214829Superoxide activates mitochondrial uncoupling proteins
Q40348831Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.
Q34180844TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
Q89878907TLR2 Signaling Pathway Combats Streptococcus uberis Infection by Inducing Mitochondrial Reactive Oxygen Species Production
Q91730245Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly
Q35311331Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice
Q45917921Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide/galactosamine-induced acute liver injury.
Q57175954Targeting Mitochondrial Ion Channels to Fight Cancer
Q37368662The Growth Factor Receptor ERBB2 Regulates Mitochondrial Activity on a Signaling Time Scale
Q64354593The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine
Q37828524The Peroxide Dilemma: Opposing and Mediating Insulin Action
Q33688482The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1
Q37888996The Regulation and Physiology of Mitochondrial Proton Leak
Q64102449The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain
Q36188890The Role of Reactive Oxygen Species in Modulating the Caenorhabditis elegans Immune Response
Q46282020The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke After Recanalization.
Q37857051The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds
Q45969409The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: role of extracellular signal-regulated kinases in bioenergetics adaptation and cell survival.
Q37242460The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction
Q34328284The dysmetabolic syndrome
Q46435677The effects of the overexpression of recombinant uncoupling protein 2 on proliferation, migration and plasminogen activator inhibitor 1 expression in human vascular smooth muscle cells
Q38967010The emerging neuroprotective role of mitochondrial uncoupling protein-2 in traumatic brain injury
Q37651334The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis
Q49835166The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism
Q37760219The estrogen-related receptor alpha: the oldest, yet an energetic orphan with robust biological functions
Q59699365The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue
Q51360789The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.
Q24803903The mitochondrial uncoupling proteins
Q50308475The mitochondrial uncoupling-protein homologues
Q39946807The multiple contributions of thyroid hormone to heat production
Q37287583The pathophysiology of mitochondrial disease as modeled in the mouse
Q33936374The regulation and turnover of mitochondrial uncoupling proteins.
Q41574195The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity.
Q38644234The role of mitochondrial ROS in antibacterial immunity.
Q33604034The role of mitochondrial uncoupling proteins in lifespan
Q35986088The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine.
Q37903726The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
Q35178608The role of uncoupling proteins in the regulation of metabolism
Q48500313The uncoupling protein 2 -866G > a polymorphism is associated with the risk of ischemic stroke in Chinese type 2 diabetic patients
Q49892676Therapeutic effects of oral liothyronine on aluminum phosphide poisoning as an adjuvant therapy: A clinical trial
Q42508041Through modulation of cardiac Ca2+ handling, UCP2 affects cardiac electrophysiology and influences the susceptibility for Ca2+ -mediated arrhythmias
Q35130103Thyroid hormone and uncoupling proteins.
Q35890452Timing of nutrient restriction and programming of fetal adipose tissue development.
Q41925778Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models
Q43260314Tissue-specific distribution of uncoupling proteins in normal rats and rats with high-fat-diet-induced obesity
Q43993580Trans-10, cis-12, but not cis-9, trans-11 CLA isomer, inhibits brown adipocyte thermogenic capacity
Q28507927Tumour suppressor Fus1 provides a molecular link between inflammatory response and mitochondrial homeostasis
Q38677857Type 2 Diabetes and Hearing Impairment
Q33312956UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells
Q40953171UCP-2 is involved in angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice
Q92957643UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses
Q34600718UCP2 deficiency helps to restrict the pathogenesis of experimental cutaneous and visceral leishmaniosis in mice
Q28482135UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior
Q40180611UCP2 is a mitochondrial transporter with an unusual very short half-life
Q36954492UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival
Q42093728UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis
Q47100190UCP2 overexpression enhanced glycolysis via activation of PFKFB2 during skin cell transformation
Q37478060UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis
Q36796078UCP2 regulates the glucagon response to fasting and starvation
Q96017518UCP2 silencing in glioblastoma reduces cell proliferation and invasiveness by inhibiting p38 MAPK pathway
Q37519690UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.
Q38117540UCP2, a mitochondrial protein regulated at multiple levels.
Q35056779UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
Q92609610UCP2-induced hypoxia promotes lipid accumulation and tubulointerstitial fibrosis during ischemic kidney injury
Q37088850UCP3 Regulates Single-Channel Activity of the Cardiac mCa1
Q37443953Uncouple my heart: the benefits of inefficiency
Q48628749Uncoupling Protein 2 (UCP2) Function in the Brain as Revealed by the Cerebral Metabolism of (1-13C)-Glucose
Q58122307Uncoupling Protein 2 (UCP2) as Genetic Risk Factor for Obesity in Indonesia is Different in Gender Stratification
Q41890358Uncoupling Protein 2 Impacts Endothelial Phenotype via p53-Mediated Control of Mitochondrial Dynamics
Q46311578Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects
Q58335880Uncoupling Protein 2 in Cardiovascular Health and Disease
Q41323838Uncoupling Protein, UCP-4 May Be Involved in Neuronal Defects During Aging and Resistance to Pathogens in Caenorhabditis elegans
Q84691907Uncoupling Protein-2 Deficient Mice Are Not Protected Against Warm Ischemia/Reperfusion Injury of the Liver
Q21089892Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells
Q38061273Uncoupling and reactive oxygen species (ROS) – A double-edged sword for β-cell function? “Moderation in all things”
Q73256790Uncoupling expectations
Q50502462Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria
Q35971116Uncoupling protein 1 of brown adipocytes, the only uncoupler: a historical perspective
Q44082392Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold
Q34332011Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients
Q39205505Uncoupling protein 2 and metabolic diseases
Q46604809Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation
Q37702665Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer.
Q86074211Uncoupling protein 2 gene (UCP2) 45-bp I/D polymorphism is associated with adiposity among Malaysian women
Q35088315Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis.
Q48452324Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord
Q28073738Uncoupling protein 2 in the glial response to stress: implications for neuroprotection
Q46422183Uncoupling protein 2 involved in protection of glucagon-like peptide 2 in small intestine with ischemia-reperfusion injury in mice
Q53556465Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes
Q34035403Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages
Q37033733Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells.
Q44564165Uncoupling protein 2, but not uncoupling protein 1, is expressed in the female mouse reproductive tract.
Q74122142Uncoupling protein 2: Adiposity angel and diabetes devil?
Q35213431Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production
Q40816499Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.
Q37708737Uncoupling protein UCP2: when mitochondrial activity meets immunity.
Q36481271Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan
Q42458989Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria.
Q44759278Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice.
Q45213390Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.
Q34240788Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress
Q33842742Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets
Q38299277Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
Q31149457Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
Q95269421Uncoupling protein-2 regulates M1 macrophage infiltration of gingiva with periodontitis
Q37162281Uncoupling protein-2 regulates lifespan in mice.
Q45035017Uncoupling protein-3 sensitizes cells to mitochondrial-dependent stimulus of apoptosis.
Q37901603Uncoupling proteins and the control of mitochondrial reactive oxygen species production
Q35070365Uncoupling proteins, dietary fat and the metabolic syndrome
Q30684562Uncoupling proteins--a new family of proteins with unknown function
Q73189686Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice
Q37065665Uncoupling proteins: role in insulin resistance and insulin insufficiency
Q34335456Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered
Q35837305Uninephrectomy in rats on a fixed food intake results in adipose tissue lipolysis implicating spleen cytokines
Q78807343Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid-treatment
Q28480923Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K
Q41192798Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity.
Q24656627Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes
Q44576005Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog
Q51653311Up‐regulation of mitochondrial uncoupling protein 3 reveals an early muscular metabolic defect in amyotrophic lateral sclerosis
Q33505454Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study
Q36492549Volume transmission and wiring transmission from cellular to molecular networks: history and perspectives
Q95481300WITHDRAWN: RIP140 mediates hyperglycemia-induced glucotoxicity in β-cells via the activation of JNK and ERK1/2 signaling pathways
Q33319550mtDNA nt13708A variant increases the risk of multiple sclerosis
Q36098005trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease

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