Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.

scientific article

Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2017.350
P8608Fatcat IDrelease_s66rmm7tqrdijk6lyubqnbod3i
P698PubMed publication ID28967903

P50authorAnna SablinaQ56769690
Veerle JanssensQ42184056
P2093author name stringJ Crowther
P Pauwels
L Libbrecht
X Sagaert
C Lambrecht
J V Louis
W Sents
Y Hoorne
P2860cites workB56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERKQ24303557
The tumor suppressor PP2A Abeta regulates the RalA GTPaseQ24307546
Identification of c-MYC as a target of the APC pathwayQ24310637
Identification of PP2A complexes and pathways involved in cell transformationQ24316472
CIP2A inhibits PP2A in human malignanciesQ24319683
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant gliomaQ24322118
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiationQ24627354
TopHat: discovering splice junctions with RNA-SeqQ24655505
Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid LeukemiaQ26752430
PPP2R5C Couples Hepatic Glucose and Lipid HomeostasisQ27310235
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
The Sequence Alignment/Map format and SAMtoolsQ27860966
Downregulation of PPP2R5E is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cellsQ42583764
Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulationQ43240765
Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal developmentQ43512505
New targets of beta-catenin signaling in the liver are involved in the glutamine metabolismQ44226601
PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation.Q47072710
PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer DevelopmentQ47632108
Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential.Q48064023
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.Q52561781
CIP2A is highly expressed in hepatocellular carcinoma and predicts poor prognosis.Q54298803
Cutadapt removes adapter sequences from high-throughput sequencing readsQ55953584
Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetranceQ72306282
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasmsQ73540311
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndromeQ81166001
Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicityQ81223136
Mutation of PPP2R1A: a new clue in unveiling the pathogenesis of uterine serous carcinomaQ83698217
Lymphomas and leukemias in miceQ83815801
The protein phosphatase 2A B56γ regulatory subunit is required for heart developmentQ87098913
PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cellsQ88079269
Creation of human tumour cells with defined genetic elementsQ28141602
Identification of specific PP2A complexes involved in human cell transformationQ28248124
Alterations of the PPP2R1B gene in human lung and colon cancerQ28284845
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2AQ28609056
BEDTools: a flexible suite of utilities for comparing genomic featuresQ29547332
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsQ29614700
Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback PathwayQ30464719
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3betaQ30473576
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformationQ33591386
Targeting c-MYC by antagonizing PP2A inhibitors in breast cancerQ33835127
A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2AQ33976501
Enumeration of the simian virus 40 early region elements necessary for human cell transformationQ34117528
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancerQ34357796
MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.Q34983172
Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout miceQ35192607
iRegulon: from a gene list to a gene regulatory network using large motif and track collectionsQ35212382
PP2A: the expected tumor suppressorQ36015508
p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformationQ36016730
Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent mannerQ36172723
Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into PracticeQ36199751
The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1.Q36782507
Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic studyQ37044144
Central role of c-Myc during malignant conversion in human hepatocarcinogenesisQ37186775
Protein phosphatase 2A: a target for anticancer therapyQ38103646
Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target.Q38160825
Molecular profiling of liver tumors: classification and clinical translation for decision makingQ38264952
All roads lead to PP2A: exploiting the therapeutic potential of this phosphataseQ38617799
Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.Q38754146
Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activityQ38969632
B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activityQ39145503
PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortalityQ39181062
α4 is highly expressed in carcinogen-transformed human cells and primary human cancersQ39588362
Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in miceQ40516271
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cellsQ40572608
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)544-552
P577publication date2017-10-02
P1433published inOncogeneQ1568657
P1476titleLoss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo
P478volume37

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cites work (P2860)
Q92864431PP2A: A Promising Biomarker and Therapeutic Target in Endometrial Cancer
Q92740861PPM1G forms a PPP-type phosphatase holoenzyme with B56δ that maintains adherens junction integrity
Q89781864PPP2R5D-Related Intellectual Disability and Neurodevelopmental Delay: A Review of the Current Understanding of the Genetics and Biochemical Basis of the Disorder
Q57169683Targeted Therapies in Type II Endometrial Cancers: Too Little, but Not Too Late
Q89835318The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets
Q54112403The impact of phosphatases on proliferative and survival signaling in cancer.

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