Subcellular localization patterns of transglutaminase 2 in astrocytes and neurons are differentially altered by hypoxia

scientific article published on 27 September 2017

Subcellular localization patterns of transglutaminase 2 in astrocytes and neurons are differentially altered by hypoxia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/WNR.0000000000000895
P8608Fatcat IDrelease_aeqgij3ghjc75fzv577qafryqq
P932PMC publication ID5685886
P698PubMed publication ID28957946

P2093author name stringGail V W Johnson
Julianne Feola
Laura Yunes-Medina
P2860cites workCytosolic guanine nucledotide binding deficient form of transglutaminase 2 (R580a) potentiates cell death in oxygen glucose deprivationQ21560855
Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectinQ24680821
Transglutaminase 2: an enigmatic enzyme with diverse functionsQ28205648
Cellular functions of tissue transglutaminaseQ28260600
Intracellular localization and conformational state of transglutaminase 2: implications for cell deathQ33476870
Transglutaminase regulation of cell function.Q33707936
Vascular events after spinal cord injury: contribution to secondary pathogenesisQ33951619
Astrocyte-derived tissue transglutaminase interacts with fibronectin: a role in astrocyte adhesion and migration?Q34031863
Characterization of distinct sub-cellular location of transglutaminase type II: changes in intracellular distribution in physiological and pathological statesQ34517980
Transglutaminases: crosslinking enzymes with pleiotropic functionsQ35058528
Extracellular TG2: emerging functions and regulationQ35587161
Transglutaminase 2: a molecular Swiss army knifeQ35693361
Pathophysiology of stroke: lessons from animal modelsQ35956294
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activationQ36241237
Transglutaminase and polyamination of tubulin: posttranslational modification for stabilizing axonal microtubulesQ36768195
Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signalingQ36804922
Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancerQ36879220
Tissue transglutaminase promotes or suppresses tumors depending on cell context.Q37520382
Transglutaminase 2 modulation of NF-κB signaling in astrocytes is independent of its ability to mediate astrocytic viability in ischemic injuryQ38682039
Appearance of tissue transglutaminase in astrocytes in multiple sclerosis lesions: a role in cell adhesion and migration?Q39664398
Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cellsQ39786229
Intracellular localization and activity state of tissue transglutaminase differentially impacts cell deathQ40608257
Complete transglutaminase 2 ablation results in reduced stroke volumes and astrocytes that exhibit increased survival in response to ischemiaQ40998895
Reduced expression of tissue transglutaminase in a human endothelial cell line leads to changes in cell spreading, cell adhesion and reduced polymerisation of fibronectin.Q41074541
Transglutaminase 2 facilitates or ameliorates HIF signaling and ischemic cell death depending on its conformation and localizationQ42403952
Transglutaminase 2 protects against ischemic strokeQ42563371
A novel RGD-independent cel adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikisQ42802185
Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domainQ42809903
Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: effects on cellular morphology and adhesionQ42816111
Increased expression of tissue-type transglutaminase following middle cerebral artery occlusion in ratsQ44899092
Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemiaQ44917306
Expression of tissue-type transglutaminase (tTG) and the effect of tTG inhibitor on the hippocampal CA1 region after transient ischemia in gerbilsQ46050087
Cell death in primary cultures of mouse neurons and astrocytes during exposure to and 'recovery' from hypoxia, substrate deprivation and simulated ischemiaQ48171569
Inhibition or ablation of transglutaminase 2 impairs astrocyte migration.Q48412795
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectastrocyteQ502961
P304page(s)1208-1214
P577publication date2017-09-27
P1433published inNeuroReportQ15710007
P1476titleSubcellular localization patterns of transglutaminase 2 in astrocytes and neurons are differentially altered by hypoxia
P478volume28

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cites work (P2860)
Q89405903Depletion of astrocytic transglutaminase 2 improves injury outcomes
Q47338630Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability
Q51736001Transglutaminase 2: Friend or foe? The discordant role in neurons and astrocytes.