Cell-based therapeutic strategies for multiple sclerosis

scientific article published on 21 July 2017

Cell-based therapeutic strategies for multiple sclerosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1093/BRAIN/AWX154
P932PMC publication ID5841198
P698PubMed publication ID29053779

P2093author name stringMarcelo Pasquini
Stephen C Reingold
Jeffrey A Cohen
Neil J Scolding
International Conference on Cell-Based Therapies for Multiple Sclerosis
International Conference on Cell-Based Therapies for Multiple Sclerosis
International Conference on Cell-Based Therapies for Multiple Sclerosis
P2860cites workNon-expanded adipose stromal vascular fraction cell therapy for multiple sclerosisQ21245469
Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of miceQ24534272
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cellsQ24632072
Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensingQ24632520
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicineQ24632756
Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCTQ24685958
Is it time to target no evident disease activity (NEDA) in multiple sclerosis?Q26801550
Cell fusion in the brain: two cells forward, one cell back.Q27691973
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementQ27861120
Adult rat and human bone marrow stromal cells differentiate into neuronsQ28142919
Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in ratsQ28209989
Disability outcome measures in multiple sclerosis clinical trials: current status and future prospectsQ28264862
World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjectsQ28300546
Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axonsQ28367760
Mesenchymal stem cells in health and diseaseQ29614296
Mesenchymal and haematopoietic stem cells form a unique bone marrow nicheQ29616602
Somatic coding mutations in human induced pluripotent stem cellsQ29616798
Mesenchymal stem cells reside in virtually all post-natal organs and tissuesQ29617740
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6Q29620590
Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouseQ30514192
Secondary autoimmune diseases occurring after HSCT for an autoimmune disease: a retrospective study of the EBMT Autoimmune Disease Working PartyQ33395411
Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivoQ33949125
Premyelinating oligodendrocytes in chronic lesions of multiple sclerosisQ34109903
Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosisQ34120467
Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot studyQ34132522
Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brainQ34287449
A randomized trial of mesenchymal stem cells in multiple system atrophy.Q34290126
Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinicQ34345195
A regenerative approach to the treatment of multiple sclerosisQ34376469
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.Q34433743
Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trialsQ34469147
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivoQ34472745
Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammationQ34503325
Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experienceQ59389207
Remyelination of CNS axons by Schwann cells transplanted from the sciatic nerveQ67551674
FDA should stand firm on stem-cell treatmentsQ74207390
Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primatesQ78654754
Bone marrow transdifferentiation in brain after transplantation: a retrospective studyQ80035903
Normal bone marrow hematopoietic stem cell reserves and normal stromal cell function support the use of autologous stem cell transplantation in patients with multiple sclerosisQ81311474
Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatmentQ81475298
Cell therapy medical tourism: time for actionQ82439275
Sustained improvement in Expanded Disability Status Scale as a new efficacy measure of neurological change in multiple sclerosis: treatment effects with natalizumab in patients with relapsing multiple sclerosisQ83661349
Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosisQ83712580
Mitochondria to the rescueQ84074088
Autologous hematopoietic stem cell transplantation for multiple sclerosis--if confused or hesitant, remember: 'treat with standard immune suppressive drugs and if no inflammation, no response'Q84198425
Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD.Q34553334
Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosisQ34564111
Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis.Q34600820
Multiple sclerosis: an immune or neurodegenerative disorder?Q34786872
Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II studyQ34934840
Endogenous tissue plasminogen activator mediates bone marrow stromal cell-induced neurite remodeling after stroke in miceQ34978504
Medical innovation versus stem cell tourismQ34989100
A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overviewQ35181841
Adult stem cells for tissue repair - a new therapeutic concept?Q35194623
Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammationQ35665181
The cost of multiple sclerosis drugs in the US and the pharmaceutical industry: Too big to fail?Q35671001
Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapyQ35677088
Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept studyQ35757641
Adult stem cells--reprogramming neurological repair?Q35832764
Inclusion of brain volume loss in a revised measure of 'no evidence of disease activity' (NEDA-4) in relapsing-remitting multiple sclerosisQ35846504
Prospective Validation of the Predictive Power of the Hematopoietic Cell Transplantation Comorbidity Index: A Center for International Blood and Marrow Transplant Research StudyQ35882830
Survival in MS: a randomized cohort study 21 years after the start of the pivotal IFNβ-1b trial.Q35909839
CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cellsQ36002391
Repeat infusion of autologous bone marrow cells in multiple sclerosis: protocol for a phase I extension study (SIAMMS-II).Q36053680
A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paperQ36075481
Assessment of bone marrow-derived Cellular Therapy in progressive Multiple Sclerosis (ACTiMuS): study protocol for a randomised controlled trialQ36163721
Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models.Q36188460
Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients.Q36402704
Therapeutic Advances and Future Prospects in Progressive Forms of Multiple SclerosisQ36484443
Advances in and Algorithms for the Treatment of Relapsing-Remitting Multiple SclerosisQ36484448
Cortical remyelination: a new target for repair therapies in multiple sclerosis.Q36504051
Glial progenitor cell-based treatment and modeling of neurological diseaseQ36544289
Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.Q36793938
Neurogenesis in the chronic lesions of multiple sclerosisQ36851475
Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosisQ36861620
Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR GuidelinesQ37017086
Remyelination of the spinal cord following intravenous delivery of bone marrow cellsQ37020042
Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosisQ37124529
Autologous haematopoietic stem-cell transplantation in multiple sclerosisQ37195389
Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis.Q37253314
New ISSCR guidelines underscore major principles for responsible translational stem cell researchQ37337489
Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent MechanismQ37350687
Long-term evolution of multiple sclerosis disability in the treatment era.Q37409279
Risk factors for Epstein-Barr virus-related post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantationQ37552052
T cell repertoire following autologous stem cell transplantation for multiple sclerosisQ37602168
High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis (HALT-MS): a 3-year interim reportQ37603718
The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study GroupQ37677911
Human bone marrow and adipose tissue mesenchymal stem cells: a user's guideQ37756932
Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?Q37769909
Resetting autoimmunity in the nervous system: The role of hematopoietic stem cell transplantation.Q37820918
The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanismsQ37978701
Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells.Q37999098
Functional heterogeneity of mesenchymal stem cells: implications for cell therapyQ38003340
Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesisQ38193251
Concise review: optimizing expansion of bone marrow mesenchymal stem/stromal cells for clinical applicationsQ38200506
Patient-Funded Trials: Opportunity or Liability?Q38562564
Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosisQ38734508
Pushing Forward: Remyelination as the New Frontier in CNS DiseasesQ38768775
Up-to-date tools for risk assessment before allogeneic hematopoietic cell transplantationQ38858092
Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple SclerosisQ38939585
Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trialQ38946774
Mesenchymal stem cells (MSC) derived from mice with experimental autoimmune encephalomyelitis (EAE) suppress EAE and have similar biological properties with MSC from healthy donorsQ39102182
Copy number variation and selection during reprogramming to pluripotencyQ39582693
Freedom from disease activity in multiple sclerosisQ39876366
Autologous mesenchymal stem cell therapy in progressive multiple sclerosis: an open label studyQ40271549
Immune-modifying agents do not impair the survival, migration or proliferation of oligodendrocyte progenitors (CG-4) in vitroQ40640875
Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing.Q41046577
Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: a randomized, placebo-controlled, multiple-dose study.Q41310202
Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patientsQ41715953
Survival and Functionality of Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes in a Nonhuman Primate Model for Multiple Sclerosis.Q42708770
Adult human mesenchymal cells proliferate and migrate in response to chemokines expressed in demyelinationQ42735915
Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis.Q43578851
The potential of human umbilical cord-derived mesenchymal stem cells as a novel cellular therapy for multiple sclerosisQ44239818
Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience.Q44475978
Possible induction of acute disseminated encephalomyelitis (ADEM)-like demyelinating illness by intrathecal mesenchymal stem cell injection.Q44756601
Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cellsQ45148313
Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot studyQ45869701
Selling Stem Cells in the USA: Assessing the Direct-to-Consumer IndustryQ46070761
Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantationQ46226618
Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis.Q47586113
Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factorQ47590532
Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseasesQ47619959
Long-term outcomes of autologous hematopoietic stem cell transplantation with reduced-intensity conditioning in multiple sclerosis: physician's and patient's perspectivesQ48048274
Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunityQ48112332
The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study.Q48183752
Induction of neurotrophin expression via human adult mesenchymal stem cells: implication for cell therapy in neurodegenerative diseasesQ48201557
Association of nonmyeloablative hematopoietic stem cell transplantation with neurological disability in patients with relapsing-remitting multiple sclerosis.Q48368793
Mesenchymal stem cell-secreted superoxide dismutase promotes cerebellar neuronal survivalQ48371412
Purkinje cell fusion and binucleate heterokaryon formation in multiple sclerosis cerebellumQ48378074
T cells become licensed in the lung to enter the central nervous systemQ48401917
Evaluation of no evidence of disease activity in a 7-year longitudinal multiple sclerosis cohortQ48403390
Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis miceQ48497239
Glioproliferative Lesion of the Spinal Cord as a Complication of "Stem-Cell Tourism".Q48662262
Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trialQ48682192
Brain atrophy after bone marrow transplantation for treatment of multiple sclerosisQ48704224
NEDA status in highly active MS can be more easily obtained with autologous hematopoietic stem cell transplantation than other drugs.Q48721170
Intravenous autologous bone marrow mononuclear cells for ischemic strokeQ49015926
[Transplantation of mesenchymal stem cells in multiple sclerosis].Q50526194
Autologous hematopoietic stem cell transplantation in multiple sclerosis: a phase II trial.Q52967863
Haematopoietic stem cell transplants should be a second-line therapy for highly active MS - NO.Q53063105
Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation.Q53171235
Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.Q53352599
Bone marrow mesenchymal stromal cells isolated from multiple sclerosis patients have distinct gene expression profile and decreased suppressive function compared with healthy counterparts.Q54565698
Reciprocal Th1 and Th17 regulation by mesenchymal stem cells: Implication for multiple sclerosisQ57041496
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecthematopoietic stem cell transplantationQ1128050
multiple sclerosisQ8277
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)2776-2796
P577publication date2017-11-01
P1433published inBrainQ897386
P1476titleCell-based therapeutic strategies for multiple sclerosis
P478volume140