Bone marrow mesenchymal stromal cells isolated from multiple sclerosis patients have distinct gene expression profile and decreased suppressive function compared with healthy counterparts.

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Bone marrow mesenchymal stromal cells isolated from multiple sclerosis patients have distinct gene expression profile and decreased suppressive function compared with healthy counterparts. is …
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scholarly articleQ13442814

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P356DOI10.3727/096368913X675142
P698PubMed publication ID24256874
P5875ResearchGate publication ID258822703

P50authorDimas CovasQ37366804
Daniel Guariz PinheiroQ42877178
Eduardo Antonio DonadiQ56449381
Rodrigo A PanepucciQ56616469
Doralina Guimarães Brum SouzaQ62743417
G L V de OliveiraQ83942515
P2093author name stringBelinda P Simões
Kelen C R Malmegrim
Maria C de Oliveira
Patrícia V B Palma
Amanda M Colombini
Kalil W A de Lima
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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
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A molecular trio in relapse and remission in multiple sclerosisQ28245076
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Autoimmune T cell responses in the central nervous systemQ33620003
Developing therapeutics for the treatment of multiple sclerosisQ33946995
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Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosisQ34120467
Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot studyQ34132522
New diagnostic criteria for multiple sclerosis: guidelines for research protocolsQ34271601
Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosisQ34564111
The promise of stem cell and regenerative therapies for multiple sclerosisQ34781833
Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept studyQ35757641
Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelinesQ35861182
Cell therapy for autoimmune diseasesQ35868954
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Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients.Q36402704
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Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10.Q37241672
Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis.Q37253314
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Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cellsQ37924625
The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanismsQ37978701
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Multipotent mesenchymal stromal cells and the innate immune systemQ38005275
Will the real multiple sclerosis please stand up?Q38020092
Mesenchymal stromal cells: a key player in 'innate tolerance'?Q38026931
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Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in vitro.Q40241704
Autologous hematopoietic stem cell transplantation as a treatment option for aggressive multiple sclerosis.Q44621693
In vitro assessment of mesenchymal stem cells immunosuppressive potential in multiple sclerosis patientsQ45011534
Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells.Q45834735
Brazilian experience with two conditioning regimens in patients with multiple sclerosis: BEAM/horse ATG and CY/rabbit ATG.Q45936271
Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanismsQ46390299
Human bone marrow stromal cell treatment improves neurological functional recovery in EAE miceQ46499204
Distinct immunomodulatory and migratory mechanisms underpin the therapeutic potential of human mesenchymal stem cells in autoimmune demyelination.Q46636028
Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitisQ48227850
Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis miceQ48497239
Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis.Q50632074
Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy.Q50767537
Mesenchymal stem cells for graft-versus-host disease: close encounters with T cells.Q53476120
Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis.Q53523180
P433issue2
P921main subjectmultiple sclerosisQ8277
P304page(s)151-165
P577publication date2013-11-20
P1433published inCell TransplantationQ15761863
P1476titleBone marrow mesenchymal stromal cells isolated from multiple sclerosis patients have distinct gene expression profile and decreased suppressive function compared with healthy counterparts.
P478volume24

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cites work (P2860)
Q35710705A Methodology for the Development of RESTful Semantic Web Services for Gene Expression Analysis
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Q39233323Cell Therapy for Multiple Sclerosis
Q47885870Cell-based therapeutic strategies for multiple sclerosis
Q48503911Increased motility of mesenchymal stem cells is correlated with inhibition of stimulated peripheral blood mononuclear cells in vitro
Q51692400Influence of the intensity and loading time of direct current electric field on the directional migration of rat bone marrow mesenchymal stem cells.
Q41196008Multipotent mesenchymal stromal cells from patients with newly diagnosed type 1 diabetes mellitus exhibit preserved in vitro and in vivo immunomodulatory properties.
Q38734508Pilot trial of intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis
Q47363542Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro
Q49343380Reduced neuroprotective potential of the mesenchymal stromal cell secretome with ex vivo expansion, age and progressive multiple sclerosis
Q91761207Short and Long Term Clinical and Immunologic Follow up after Bone Marrow Mesenchymal Stromal Cell Therapy in Progressive Multiple Sclerosis-A Phase I Study
Q54988530Transcriptional Profiling of Mesenchymal Stem Cells Identifies Distinct Neuroimmune Pathways Altered by CNS Disease.
Q37089931Transcriptional profiling reveals intrinsic mRNA alterations in multipotent mesenchymal stromal cells isolated from bone marrow of newly-diagnosed type 1 diabetes patients

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