Ribosomal incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase

scientific article

Ribosomal incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/C7OB02931D
P932PMC publication ID5993425
P698PubMed publication ID29367962

P50authorEmil S IqbalQ64181851
P2093author name stringMatthew C T Hartman
Kara K Dods
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Outwitting EF-Tu and the ribosome: translation with d-amino acidsQ41127564
Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathwayQ43582952
A conserved threonine within Escherichia coli leucyl-tRNA synthetase prevents hydrolytic editing of leucyl-tRNALeuQ43593814
Cell-free translation reconstituted with purified componentsQ43692142
Genetic incorporation of 4-fluorohistidine into peptides enables selective affinity purificationQ45059337
Site-specific incorporation of novel backbone structures into proteinsQ45093503
Amino acid backbone specificity of the Escherichia coli translation machineryQ45093901
A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteinsQ46323212
Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporationQ47137027
In Vivo Biosynthesis of a β-Amino Acid-Containing Protein.Q50519795
Ribosomal Synthesis of Peptides with Multiple β-Amino Acids.Q51547486
Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates.Q52888301
Residue-based control of helix shape in β-peptide oligomersQ59090060
The proteolytic stability of 'designed' beta-peptides containing alpha-peptide-bond mimics and of mixed alpha,beta-peptides: application to the construction of MHC-binding peptidesQ79455284
Flexizymes for genetic code reprogrammingQ84261526
An expanded set of amino acid analogs for the ribosomal translation of unnatural peptidesQ21144426
Amino acidic scaffolds bearing unnatural side chains: an old idea generates new and versatile tools for the life sciencesQ27010408
An Evolved Aminoacyl-tRNA Synthetase with Atypical Polysubstrate Specificity,Q27666793
Recent developments of engineered translational machineries for the incorporation of non-canonical amino acids into polypeptidesQ28080804
Encodamers: unnatural peptide oligomers encoded in RNAQ28188889
Beyond the canonical 20 amino acids: expanding the genetic lexiconQ28272926
Directed evolution of high-affinity antibody mimics using mRNA displayQ31106575
Ribosomal synthesis of unnatural peptidesQ33221816
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Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligationQ33896261
Decoding the genome: a modified viewQ33975049
Modulation of tRNAAla identity by inorganic pyrophosphataseQ34027482
β-Puromycin selection of modified ribosomes for in vitro incorporation of β-amino acids.Q34092803
In vitro selection of highly modified cyclic peptides that act as tight binding inhibitorsQ34201330
Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viabilityQ34463866
Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center.Q34572497
Polyspecific pyrrolysyl-tRNA synthetases from directed evolutionQ34601742
Replacing amino acids in translation: expanding chemical diversity with non-natural variantsQ34747039
Programming peptidomimetic syntheses by translating genetic codes designed de novoQ35142895
Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogrammingQ35747679
A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targetsQ36250421
Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA DisplayQ36266199
The flexizyme system: a highly flexible tRNA aminoacylation tool for the translation apparatusQ36947740
Design of cyclic peptides that bind protein surfaces with antibody-like affinityQ37106690
Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applicationsQ37808851
Biosynthesis and function of posttranscriptional modifications of transfer RNAsQ38035925
P433issue7
P304page(s)1073-1078
P577publication date2018-01-25
P1433published inOrganic and Biomolecular ChemistryQ3355939
P1476titleRibosomal incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase
P478volume16

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cites work (P2860)
Q64947139Plasticity and Constraints of tRNA Aminoacylation Define Directed Evolution of Aminoacyl-tRNA Synthetases.
Q98665254Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids

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