Chemistry and Biology of Teixobactin

scientific article published on 9 October 2017

Chemistry and Biology of Teixobactin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CHEM.201704167
P8608Fatcat IDrelease_7prboqmhvbed5iowo3p2dtjj4y
P698PubMed publication ID28991382

P50authorQi ZhangQ57045815
P2093author name stringJiangtao Gao
Dhanaraju Mandalapu
Xinjian Ji
Chuchu Guo
P2860cites workA new antibiotic kills pathogens without detectable resistanceQ24091299
Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial speciesQ24605448
Structural and Functional Characterization of MppR, an Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus : Functional Diversity in the Acetoacetate Decarboxylase-like SuperfamilyQ27678584
Streptomyces wadayamensis MppP Is a Pyridoxal 5'-Phosphate-Dependent L-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic PathwayQ27702595
The sypA, sypB, and sypC Synthetase Genes Encode Twenty-Two Modules Involved in the Nonribosomal Peptide Synthesis of Syringopeptin by Pseudomonas syringae pv. syringae B301DQ28203866
Antibacterial natural products in medicinal chemistry--exodus or revival?Q28255204
The Activation of Free Dipeptides Promoted by Strong Activating Agents in Water Does not Yield Diketopiperazines.Q47392948
Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).Q47969690
Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architectureQ48058009
Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activitiesQ48310474
Antibiotics: Recover the lost art of drug discoveryQ48438044
Efficient total syntheses and biological activities of two teixobactin analoguesQ49064838
Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of l-allo-enduracididine with its isosteres.Q50560970
Multiple attack on bacteria by the new antibiotic teixobactin.Q52866776
Synthesis and Biological Evaluation of a Teixobactin Analogue.Q53181587
In vivo characterization of tandem C-terminal thioesterase domains in arthrofactin synthetase.Q53568562
Total Synthesis of Teixobactin.Q53785473
Antibakterielle Naturstoffe in der medizinischen Chemie – Exodus oder Renaissance?Q56625626
Re-evaluation of the N-terminal substitution and the D-residues of teixobactinQ57179926
Lysine Scanning of Arg-Teixobactin: Deciphering the Role of Hydrophobic and Hydrophilic ResiduesQ58034891
Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligationQ61779084
The role of natural products in a modern drug discovery programQ73396825
Highly efficient chiral-pool synthesis of (2S,4R)-4-hydroxyornithineQ74561107
Where will new antibiotics come from?Q79817299
A Highly Stereoselective and Scalable Synthesis of L-allo-EnduracididineQ86104359
New antibiotic discovered for Gram-positive bacteriaQ86557856
New twist on antibiotic hunt hits pay dirtQ86717812
Biosynthesis of enduracidin: Origin of enduracididine and other amino acids.Q105240831
Natural products as sources of new drugs over the 30 years from 1981 to 2010Q29616640
Origins and evolution of antibiotic resistanceQ29617791
ChemMatrix, a poly(ethylene glycol)-based support for the solid-phase synthesis of complex peptidesQ33236076
The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.Q33879176
Counting the uncountable: statistical approaches to estimating microbial diversityQ33990368
Prokaryotic diversity--magnitude, dynamics, and controlling factorsQ34127920
Vicinal diamination of alkenes under Rh-catalysisQ34282676
Tackling antibiotic resistanceQ34390844
Antibiotics: An irresistible newcomer.Q34456690
A new antibiotic and the evolution of resistanceQ34467725
Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistanceQ34547868
The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibioticsQ34550741
The mechanism of action of ramoplanin and enduracidinQ34553065
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.Q34555236
Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremiaQ34783668
Antibiotic discovery goes underground: The discovery of teixobactin could revitalise the search for new antibiotics based on the novel method the researchers used to identify the compoundQ35595463
Nonribosomal Peptide Synthesis-Principles and ProspectsQ36316177
Protein chemical synthesis by serine and threonine ligationQ36799143
Limitations of vancomycin in the management of resistant staphylococcal infectionsQ36916076
Wall teichoic acids of gram-positive bacteriaQ37442758
Elucidation of the Teixobactin PharmacophoreQ37616543
Wall teichoic acid function, biosynthesis, and inhibitionQ37629742
Teichoic acid biosynthesis as an antibiotic targetQ38126648
Molecular mechanisms of antibiotic resistance.Q38272908
Teixobactin, the first of a new class of antibiotics discovered by iChip technology?Q38531889
Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery.Q38647719
Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesisQ39112679
Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis.Q40566928
Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteriaQ40622160
Massetolide A biosynthesis in Pseudomonas fluorescens.Q42227441
Total synthesis of teixobactin.Q42375863
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogensQ42408769
The enduracidin biosynthetic gene cluster from Streptomyces fungicidicusQ42599363
NRPSpredictor2--a web server for predicting NRPS adenylation domain specificityQ42713872
Antibiotic discovery heralds new world of drugsQ43172591
X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.Q46386811
Alanine scan reveals modifiable residues in teixobactinQ46549407
Investigation of the N-Terminus Amino Function of Arg10-TeixobactinQ46690045
In silico methods for linking genes and secondary metabolites: The way forward.Q47138590
P407language of work or nameEnglishQ1860
P921main subjectteixobactinQ18720369
P577publication date2017-10-09
P1433published inChemistry—A European JournalQ898737
P1476titleChemistry and Biology of Teixobactin

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cites work (P2860)
Q90320467Addressing Antimicrobial Resistance through New Medicinal and Synthetic Chemistry Strategies
Q100730666Biosynthesis of Depsipeptides; or Depsi: The peptides with varied generations
Q91744291Crossroads of Antibiotic Resistance and Biosynthesis
Q113959317Cyclofaulknamycin with the Rare Amino Acid D-capreomycidine Isolated from a Well-Characterized Streptomyces albus Strain
Q92092107Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
Q87891234Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus
Q97686488Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification
Q90415948New perspectives on the treatment of mycobacterial infections using antibiotics
Q54217425Rational design and synthesis of modified teixobactin analogues: in vitro antibacterial activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa.
Q91025129Solution-phase total synthesis of teixobactin
Q92407556Strategies for discovery of new molecular targets for anti-infective drugs
Q91625649Synthesis and structure-activity relationships of teixobactin
Q99708838Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model
Q96291752Teixobactin: A Paving Stone towards A New Class of Antibiotics?
Q95839089The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study
Q92467090The impact of backbone N-methylation on the structure-activity relationship of Leu10 -teixobactin
Q48192881Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity.
Q90331505Total Solid-Phase Synthesis of Dehydroxy Fengycin Derivatives

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