Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

scientific article published on 22 July 2019

Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2019NatCo..10.3268Z
P356DOI10.1038/S41467-019-11211-Y
P932PMC publication ID6646333
P698PubMed publication ID31332172

P50authorKirsten J MeyerQ61155187
Liguo WangQ92092102
P2093author name stringFang Fang
Jingren Zhang
Yu Rao
Kim Lewis
Yu Zong
Hongying Gao
Zhihao Ni
P2860cites workA new antibiotic kills pathogens without detectable resistanceQ24091299
Total synthesis of lysobactinQ24684181
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracyQ28251042
Fix the antibiotics pipeline.Q34176763
Vicinal diamination of alkenes under Rh-catalysisQ34282676
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Elucidation of the Teixobactin PharmacophoreQ37616543
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Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian CancerQ39130754
Metal-catalysed 1,2-diamination reactionsQ39967149
Stereoselective Synthesis of Cyclic Guanidines by Directed Diamination of Unactivated AlkenesQ41103743
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Total synthesis of teixobactin.Q42375863
Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study.Q46745179
Binding Modes of Teixobactin to Lipid II: Molecular Dynamics StudyQ47267177
Chemistry and Biology of TeixobactinQ48221915
Design and syntheses of highly potent teixobactin analogues against Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE) in vitro and in vivoQ49030931
Efficient total syntheses and biological activities of two teixobactin analoguesQ49064838
Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of l-allo-enduracididine with its isosteres.Q50560970
The chemistry and biology of guanidine natural products.Q51175669
Total Synthesis of Mannopeptimycins α and β.Q51494895
Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding.Q52641511
Co(OAc)2-Catalyzed Trifluoromethylation and C(3)-Selective Arylation of 2-(Propargylamino)pyridines via a 6-Endo-Dig Cyclization.Q52802311
Synthesis and Biological Evaluation of a Teixobactin Analogue.Q53181587
Total Synthesis of Teixobactin.Q53785473
X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-Like AssemblyQ57181077
Short Total Synthesis of [15N5]-Cylindrospermopsins from 15NH4Cl Enables Precise Quantification of Freshwater Cyanobacterial Contamination.Q64951167
A Highly Stereoselective and Scalable Synthesis of L-allo-EnduracididineQ86104359
Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and TeixobactinQ88305286
Structural studies suggest aggregation as one of the modes of action for teixobactinQ90972846
Probing key elements of teixobactin-lipid II interactions in membranesQ91419607
P433issue1
P921main subjecttotal synthesisQ644785
teixobactinQ18720369
P304page(s)3268
P577publication date2019-07-22
P1433published inNature CommunicationsQ573880
P1476titleGram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
P478volume10

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cites work (P2860)
Q104745275Emerging peptide antibiotics with therapeutic potential
Q95290573Bacterial aggregation triggered by fibril forming tryptophan rich sequences: effects of peptide side chain and membrane phospholipids
Q100525345De novo resistance to arg10-teixobactin occurs slowly and is costly
Q91352390Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin
Q89540494Disulfiram as a potent metallo-β-lactamase inhibitor with dual functional mechanisms
Q90634106Exploring metabolic adaptation of Streptococcus pneumoniae to antibiotics
Q96171617Mode of action of teixobactins in cellular membranes
Q100943527Spotlight on Select New Antimicrobial Innate Immune Peptides Discovered during 2015-2019
Q96609350Strategic Moves of "Superbugs" Against Available Chemical Scaffolds: Signaling, Regulation, and Challenges
Q91625649Synthesis and structure-activity relationships of teixobactin
Q112573689Synthetic antibacterial discovery of symbah-1, a macrocyclic β-hairpin peptide antibiotic
Q96291752Teixobactin: A Paving Stone towards A New Class of Antibiotics?
Q100456172The chemistry and biology of guanidine secondary metabolites

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