teixobactin

chemical compound

DBpedia resource is: http://dbpedia.org/resource/Teixobactin

Abstract is: Teixobactin (/ˌteɪksoʊˈbæktɪn/) is a peptide-like secondary metabolite of some species of bacteria, that kills some gram-positive bacteria. It appears to belong to a new class of antibiotics, and harms bacteria by binding to lipid II and , important precursor molecules for forming the cell wall. Teixobactin was discovered using a new method of culturing bacteria in soil, which allowed researchers to grow a previously unculturable bacterium now named Eleftheria terrae, which produces the antibiotic. Teixobactin was shown to kill Staphylococcus aureus and Mycobacterium tuberculosis.

Wikimedia Commons category is Teixobactin

C₅₈H₉₅N₁₅O₁₅

teixobactin is …
instance of (P31):
type of chemical entityQ113145171

sublass of (P279):
peptideQ172847
depsipeptideQ413248

External links are
P233canonical SMILESCCC(C)C1C(=O)OC(C(C(=O)NC(C(=O)NC(C(=O)N1)CC2CN=C(N2)N)C)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(C(C)CC)NC(=O)C(CCC(=O)N)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(CC3=CC=CC=C3)NC)C
P231CAS Registry Number1613225-53-8
P683ChEBI ID84192
P592ChEMBL IDCHEMBL3977597
P661ChemSpider ID32786764
P3219Encyclopædia Universalis IDteixobactine
P646Freebase ID/m/012m5py6
P595Guide to Pharmacology Ligand ID10972
P234InChIInChI=1S/C58H95N15O15/c1-12-28(5)42(70-49(79)37(61-11)23-34-19-17-16-18-20-34)53(83)67-39(26-74)51(81)65-36(21-22-41(59)76)48(78)69-44(30(7)14-3)55(85)71-43(29(6)13-2)54(84)68-40(27-75)52(82)73-46-33(10)88-57(87)45(31(8)15-4)72-50(80)38(24-35-25-62-58(60)64-35)66-47(77)32(9)63-56(46)86/h16-20,28-33,35-40,42-46,61,74-75H,12-15,21-27H2,1-11H3,(H2,59,76)(H,63,86)(H,65,81)(H,66,77)(H,67,83)(H,68,84)(H,69,78)(H,70,79)(H,71,85)(H,72,80)(H,73,82)(H3,60,62,64)/t28-,29-,30-,31-,32-,33-,35-,36+,37+,38-,39-,40-,42-,43-,44+,45-,46+/m0/s1
P235InChIKeyLMBFAGIMSUYTBN-MPZNNTNKSA-N
P2017isomeric SMILESCC[C@H](C)[C@H]1C(=O)O[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C[C@H]2CN=C(N2)N)C)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CC3=CC=CC=C3)NC)C
P6366Microsoft Academic ID2779624440
P11199Probes And Drugs IDPD131912
P662PubChem CID86341926
P3417Quora topic IDTeixobactin
P11089UniChem compound ID78871674
P652UNIILC730GUE72

P1889different fromisomer of teixobactinQ77517295
P703found in taxonEleftheria terraeQ18759674
P2067mass1241.713207
P3364stereoisomer ofisomer of teixobactinQ77517295
P2868subject has roleantibioticQ12187
polypeptide antibioticQ3818190

Reverse relations

main subject (P921)
Q24091299A new antibiotic kills pathogens without detectable resistance
Q46549407Alanine scan reveals modifiable residues in teixobactin
Q35595463Antibiotic discovery goes underground: The discovery of teixobactin could revitalise the search for new antibiotics based on the novel method the researchers used to identify the compound
Q47267177Binding Modes of Teixobactin to Lipid II: Molecular Dynamics Study
Q47609673Binding site and potency prediction of Teixobactin and other Lipid II ligands by statistical base scoring of conformational space maps.
Q48221915Chemistry and Biology of Teixobactin
Q47969690Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).
Q90270711Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell-Wall Precursor Lipid II
Q40566928Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis.
Q37616543Elucidation of the Teixobactin Pharmacophore
Q64062429Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance
Q92092107Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
Q112938483Investigating Teixobactin Tolerance in Enterococcus faecalis
Q112936990Investigating resistance in Enterococcus faecalis against the new antibiotic teixobactin
Q87891234Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus
Q96171617Mode of action of teixobactins in cellular membranes
Q52866776Multiple attack on bacteria by the new antibiotic teixobactin.
Q91419607Probing key elements of teixobactin-lipid II interactions in membranes
Q112932109Regulation of Antimicrobial Resistance in Enterococcus faecalis
Q91025129Solution-phase total synthesis of teixobactin
Q90972846Structural studies suggest aggregation as one of the modes of action for teixobactin
Q91625649Synthesis and structure-activity relationships of teixobactin
Q99708838Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model
Q38647719Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery.
Q46745179Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study.
Q113480788Teixobactin kills bacteria by a two-pronged attack on the cell envelope
Q38531889Teixobactin, the first of a new class of antibiotics discovered by iChip technology?
Q96291752Teixobactin: A Paving Stone towards A New Class of Antibiotics?
Q93197947Teixobactin: a novel anti-infective agent
Q40032243Teixobactin: a novel antibiotic in treatment of gram positive bacterial infections
Q91595245Teixobactins: a new class of 21st century antibiotics to combat multidrug-resistant bacterial pathogens
Q95839089The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study
Q92266971The Necessity of d-Thr in the New Antibiotic Teixobactin: A Molecular Dynamics Study
Q53785473Total Synthesis of Teixobactin.
Q42375863Total synthesis of teixobactin.
Q46386811X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.

Q77517295isomer of teixobactindifferent fromP1889
Q77517295isomer of teixobactinstereoisomer ofP3364

The articles in Wikimedia projects and languages

      Category:Teixobactinwikimedia
Arabic (ar / Q13955)تيكسوباكتينwikipedia
      Теиксобактинwikipedia
Catalan (ca / Q7026)Teixobactinawikipedia
      Teixobactinwikipedia
      Teixobactinwikipedia
      Teixobactinwikipedia
      Teixobactinawikipedia
Persian (fa / Q9168)تیکسوباکتینwikipedia
      Teiksobaktiiniwikipedia
      Teixobactinewikipedia
hiटीक्सोबैक्टीनwikipedia
      Teixobaktinwikipedia
      Teixobactinwikipedia
nbTeixobactinwikipedia
      Teixobactinewikipedia
      Tejksobaktynawikipedia
      Teixobactinawikipedia
      Teixobactinăwikipedia
      Теиксобактинwikipedia
      Теїксобактинwikipedia
      Teixobactinwikipedia

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