The microbiota metabolite indole inhibits Salmonella virulence: Involvement of the PhoPQ two-component system

scientific article published on 17 January 2018

The microbiota metabolite indole inhibits Salmonella virulence: Involvement of the PhoPQ two-component system is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0190613
P932PMC publication ID5771565
P698PubMed publication ID29342189

P50authorArul JayaramanQ88438985
P2093author name stringRobert C Alaniz
Nandita Kohli
Michael Li
Rebekah Riordan
Zeni Crisp
P2860cites workSdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7Q61857106
The bacterial signalling molecule indole attenuates the virulence of the fungal pathogen Candida albicansQ84440837
MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoyQ21090512
Analysis of pools of targeted Salmonella deletion mutants identifies novel genes affecting fitness during competitive infection in miceQ21131574
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR productsQ27860842
Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological researchQ29619122
Ruminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human fecesQ31004928
Indole is an inter-species biofilm signal mediated by SdiA.Q33285067
Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infectionQ33357471
The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammationQ33591608
Regulation of bacterial pathogenesis by intestinal short-chain Fatty acidsQ33642076
Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycinQ33788040
The Salmonella enterica serotype Typhimurium lpf, bcf, stb, stc, std, and sth fimbrial operons are required for intestinal persistence in miceQ33788226
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Mechanisms controlling pathogen colonization of the gut.Q34147042
Salmonella pathogenicity islands encoding type III secretion systemsQ34288964
Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharidesQ34294058
Microbiota-mediated colonization resistance against intestinal pathogensQ34324937
Lactobacillus acidophilus LA 1 binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteriaQ34378895
The Salmonella pathogenicity island-1 type III secretion systemQ34469814
Short chain fatty acids in human large intestine, portal, hepatic and venous bloodQ34529426
Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinantsQ34581467
The role of motility as a virulence factor in bacteriaQ34636277
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Effect of Microflora on the Free Amino Acid Distribution in Various Regions of the Mouse Gastrointestinal TractQ35801243
Effects of indole on drug resistance and virulence of Salmonella enterica serovar Typhimurium revealed by genome-wide analyses.Q36118186
Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophagesQ36162205
Colonization resistance of the digestive tract in conventional and antibiotic-treated miceQ36252753
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Mechanisms That Control Bacterial Populations in Continuous-Flow Culture Models of Mouse Large Intestinal FloraQ36344234
The intestinal fatty acid propionate inhibits Salmonella invasion through the post-translational control of HilDQ36636799
Formate acts as a diffusible signal to induce Salmonella invasionQ36747272
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Salmonellae interplay with host cellsQ37008201
Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic toleranceQ37143603
Indole as an intercellular signal in microbial communitiesQ37673258
Intestinal colonization resistanceQ38067461
Tryptophanase: Structure, Catalytic Activities, and Mechanism of ActionQ38105682
Butyrate specifically down-regulates salmonella pathogenicity island 1 gene expression.Q38317128
Regulation of Salmonella enterica serovar typhimurium invasion genes by csrA.Q39517248
Sites of organic acid production and absorption in gastrointestinal tract of the pigQ40310785
Intestinal short-chain fatty acids alter Salmonella typhimurium invasion gene expression and virulence through BarA/SirA.Q40687509
A rapid and specific method for the detection of indole in complex biological samplesQ40991452
Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in manQ41646819
Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and gene expressionQ42267236
AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signalsQ42423493
Mode of action of plantaricin MG, a bacteriocin active against Salmonella typhimuriumQ42850391
'Form variation' of the O12 antigen is critical for persistence of Salmonella Typhimurium in the murine intestineQ46339037
Butyrate protects Caco-2 cells from Campylobacter jejuni invasion and translocationQ46753289
Sites of organic acid production and absorption in the equine gastrointestinal tractQ47874991
Sensing by bacterial regulatory systems in host and non-host environmentsQ50078109
Displacement of bacterial pathogens from mucus and Caco-2 cell surface by lactobacilli.Q50102772
Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expressionQ50136962
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e0190613
P577publication date2018-01-17
P1433published inPLOS OneQ564954
P1476titleThe microbiota metabolite indole inhibits Salmonella virulence: Involvement of the PhoPQ two-component system
P478volume13

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cites work (P2860)
Q89983007Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole
Q90862879Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome
Q92715663Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network

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