Generation of conditional null alleles for APP and APLP2.

scientific article published in March 2010

Generation of conditional null alleles for APP and APLP2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/DVG.20601
P8608Fatcat IDrelease_wm6dxzu7erco3ckaehurj4xp7a
P698PubMed publication ID20140888

P2093author name stringMikhail A Filippov
Meike Hick
Ulrike C Müller
Jakob-Andreas Tschäpe
Jan-Philipp Mallm
P2860cites workCortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family membersQ28504488
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout miceQ28505777
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor proteinQ28513133
Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein geneQ28513269
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein geneQ28586800
Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor proteinQ28587017
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2Q28589908
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO miceQ28590025
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor proteinQ28592893
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityQ28593175
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cellsQ29614542
Amyloid precursor protein trafficking, processing, and functionQ29617429
Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmissionQ34785066
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseasesQ35934211
The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteinsQ36626425
Bridging physiology and pathology in AD.Q37518549
Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cellsQ37576797
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.Q40106778
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.Q42495065
Distribution of GABAA receptor subunit mRNAs in rat lumbar spinal cordQ43968835
Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway.Q46418672
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilinQ46755710
Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein liQ47357147
Hypersensitivity to seizures in beta-amyloid precursor protein deficient miceQ48236519
P433issue3
P304page(s)200-206
P577publication date2010-03-01
P1433published inGenesisQ5532784
P1476titleGeneration of conditional null alleles for APP and APLP2.
P478volume48

Reverse relations

cites work (P2860)
Q37902514APP physiological and pathophysiological functions: insights from animal models.
Q36005686All in the Family: How the APPs Regulate Neurogenesis
Q33622388Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression
Q33854917Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex
Q48186706Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
Q48268002Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex
Q82467947Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo
Q37935600Functions of the APP gene family in the nervous system: insights from mouse models
Q28277658Genome-wide nucleosome positioning during embryonic stem cell development
Q30666181Heterochromatin Protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells
Q39134078Neurodegenerative Disease Transmission and Transgenesis in Mice.
Q37987144Physiological functions of APP family proteins
Q59137316Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

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