Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity

scientific article published in December 1992

Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1022032963
P356DOI10.1038/360737A0
P698PubMed publication ID1361214

P50authorMai Har ShamQ38324732
P2093author name stringKrumlauf R
Marshall H
Nonchev S
Lumsden A
Muchamore I
P2860cites workRetinoic acid and development of the central nervous systemQ35271368
The expression of murine Hox-2 genes id dependent on the differenation pathway and displays a collinear sensitivity to retinoic acid in F9 cels andXenopusembroysQ35787628
Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryosQ41082593
Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformationsQ41089950
Homeosis in the mouse induced by a null mutation in the Hox-3.1 geneQ41628468
Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cellsQ41724610
Retinoic acid causes an anteroposterior transformation in the developing central nervous systemQ41931859
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6Q48530157
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expressionQ48654359
Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.Q52241650
Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formationQ59065602
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acidQ68317251
Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expressionQ68321893
Vertebrate homeobox gene nomenclatureQ28183710
Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic miceQ28257167
Expression of the homeobox Hox-4 genes and the specification of position in chick wing developmentQ28322610
Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cellsQ33246903
Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions.Q34354671
Segment-specific expression of a homoeobox-containing gene in the mouse hindbrainQ34464294
Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain.Q34464666
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5Q34531248
A distinct Hox code for the branchial region of the vertebrate headQ34545764
Retinoic acid embryopathyQ34686260
P433issue6406
P407language of work or nameEnglishQ1860
P921main subjecttretinoinQ29417
P304page(s)737-741
P577publication date1992-12-01
P1433published inNatureQ180445
P1476titleRetinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity
P478volume360

Reverse relations

cites work (P2860)
Q570054881 Body Plan Genes and Human Malformation
Q34579930A 7-base-pair sequence protects DNA from exonucleolytic degradation in Lactococcus lactis.
Q42546369A behavioral and neuroanatomical investigation of the lethality caused by gestational day 11-13 retinoic acid exposure
Q52215015A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1.
Q44497234A critical period for retinoic acid teratogenesis and loss of neurophilic migration of pontine nuclei neurons
Q24531437A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos
Q62817996A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid
Q53663556A novel method for retinoic acid administration reveals differential and dose-dependent downregulation of Fgf3 in the developing inner ear and anterior CNS.
Q52177127Abnormal anteroposterior and dorsoventral patterning of the limb bud in the absence of retinoids.
Q73508958Afferents of cranial sensory ganglia pathfind to their target independent of the site of entry into the hindbrain
Q28277857All-trans retinoic acid-responsive genes identified in the human SH-SY5Y neuroblastoma cell line and their regulated expression in the nervous system of early embryos
Q45890224All-trans-retinoic acid upregulates the expression of COUP-TFI in early-somite mouse embryos cultured in vitro
Q34411125Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1.
Q91884924An atlas of anterior hox gene expression in the embryonic sea lamprey head: Hox-code evolution in vertebrates
Q37724001An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.
Q35876078Analysis of dynamic changes in retinoid-induced transcription and epigenetic profiles of murine Hox clusters in ES cells
Q45377921Anterior-posterior patterning and segmentation of the vertebrate head
Q40447522Boundaries and inhibitory molecules in developing neural tissues.
Q38829099CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition
Q52567832Cell determination and transdetermination in Drosophila imaginal discs.
Q48081550Cloning and developmental expression of LFB3/HNF1β transcription factor in Xenopus laevis
Q48022200Cloning and sequencing of the CRABP-I locus from chicken and pufferfish: analysis of the promoter regions in transgenic mice
Q30838817Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo
Q39561291Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells increases their proliferation and delays their differentiation into oligodendrocyte-like cells expressing myelin basic protein
Q37783244Control of Vertebrate Hox Clusters by Remote and Global Cis-Acting Regulatory Sequences
Q38820880Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes
Q43181865Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes.
Q41685028Craniofacial abnormalities induced by the ectopic expression of homeobox genes
Q28282908Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid
Q36791827Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid
Q46475207Development of branchiomeric and lateral line nerves in the axolotl
Q48673976Development of branchiomotor neurons in zebrafish
Q48394026Developmental biology. Mice with half a mind
Q41500136Developmental patterning and evolution of the mammalian viscerocranium: genetic insights into comparative morphology
Q49030883Differential effects of retinoic acid and a retinoid antagonist on the spatial distribution of the homeoprotein Hoxb-7 in vertebrate embryos.
Q37696900Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
Q42739791Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors
Q82029962Disorders of segmentation of the neural tube: Chiari malformations
Q50496002Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant.
Q37566124Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome
Q48001133Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos
Q42536967Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis).
Q52209713Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo.
Q37570831Establishment of Hox vertebral identities in the embryonic spine precursors
Q34761381Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation
Q36121152Evolution of the brain developmental plan: Insights from agnathans
Q34347339Evolution of vertebrate forebrain development: how many different mechanisms?
Q48116727Exposure to retinoic acid at the onset of hindbrain segmentation induces episodic breathing in mice
Q48365861Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1.
Q41676501Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate
Q52207625Expression of the chicken retinoid X receptor-gamma gene in migrating cranial neural crest cells.
Q48070219Expression of the labial group Hox gene HrHox-1 and its alteration induced by retinoic acid in development of the ascidian Halocynthia roretzi
Q34580344Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain
Q51896499Fate of retinoic acid-activated embryonic cell lineages.
Q48249810Generating retinoic acid gradients by local degradation during craniofacial development: One cell's cue is another cell's poison.
Q33892762Genetic and molecular roles of Otx homeodomain proteins in head development.
Q41094472Genetically engineered mice: tools to understand craniofacial development
Q48621762Gestational retinoic acid exposure: a sensitive period for effects on neonatal mortality and cerebellar development
Q33738524Heads or tails? Retinoic acid will decide
Q52173212Hindbrain respecification in the retinoid-deficient quail.
Q37279198How degrading: Cyp26s in hindbrain development
Q52181884How to build a vertebrate hindbrain. Lessons from genetics.
Q36916855Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.
Q39401987Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse
Q92182315Hox genes: Downstream "effectors" of retinoic acid signaling in vertebrate embryogenesis
Q27014950Hox genes: choreographers in neural development, architects of circuit organization
Q28592998Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
Q28143128Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain
Q52173207Hoxd4 and Rarg interact synergistically in the specification of the cervical vertebrae.
Q32079279Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos
Q49321035Independent assignment of antero-posterior and dorso-ventral positional values in the developing chick hindbrain
Q44890871Independent roles for retinoic acid in segmentation and neuronal differentiation in the zebrafish hindbrain
Q47908899Induction of a parafacial rhythm generator by rhombomere 3 in the chick embryo.
Q35437790Inhibition of retinoic acid-induced activation of 3' human HOXB genes by antisense oligonucleotides affects sequential activation of genes located upstream in the four HOX clusters.
Q34185960Initial patterning of the central nervous system: how many organizers?
Q47713097Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway.
Q61053714Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder
Q92591372Inter-rhombomeric interactions reveal roles for fibroblast growth factors signaling in segmental regulation of EphA4 expression
Q48666211Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain.
Q36419839Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development
Q42643160Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development
Q28511004Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors
Q35185372Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex.
Q44492780Microarray analysis of embryonic retinoic acid target genes in the ascidian Ciona intestinalis
Q28081179Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development
Q28748830Molecular pedomorphism underlies craniofacial skeletal evolution in Antarctic notothenioid fishes
Q52196505Motor axon subpopulations respond differentially to the chemorepellents netrin-1 and semaphorin D.
Q98771678Neurogenesis From Neural Crest Cells: Molecular Mechanisms in the Formation of Cranial Nerves and Ganglia
Q37828677New insights into retinoid signaling in cardiac development and physiology
Q52193848Organization and development of facial motor neurons in the kreisler mutant mouse.
Q72057725Orphan receptor COUP‐TF I antagonizes retinoic acid‐induced neuronal differentiation
Q34183728Otx genes in brain morphogenesis
Q30499631Otx1 and Otx2 in the development and evolution of the mammalian brain
Q42678812Overexpression of a cellular retinoic acid binding protein (xCRABP) causes anteroposterior defects in developing Xenopus embryos
Q40391995Pattern formation in the vertebrate neural plate
Q34185517Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity
Q41103216Patterning the hindbrain
Q52171296Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm.
Q52214147Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants
Q34695393Precraniate origin of cranial motoneurons.
Q40458896Prenatal Craniofacial Development: New Insights On Normal and Abnormal Mechanisms
Q41001362Prenatal craniofacial development: new insights on normal and abnormal mechanisms
Q37551594Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.
Q52185039Regional pattern of retinoid X receptor-alpha gene expression in the central nervous system of the chicken embryo and its up-regulation by exposure to 9-cis retinoic acid.
Q42663340Regionalized metabolic activity establishes boundaries of retinoic acid signalling
Q28587002Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice
Q49082992Reprogramming Hox expression in the vertebrate hindbrain: influence of paraxial mesoderm and rhombomere transposition
Q36085821Restrictive clonal allocation in the chimeric mouse brain
Q52184824Retinoic acid affects patterning along the anterior-posterior axis of the ascidian embryo.
Q40960548Retinoic acid and pattern formation in vertebrates
Q40423158Retinoic acid and retinoic acid receptors in development
Q74273423Retinoic acid exposure on gestational days 11 to 13 impairs swallowing in rat offspring
Q60439765Retinoic acid in the anteroposterior patterning of the zebrafish trunk
Q48711888Retinoic acid induces a tissue-specific deletion in the expression domain of Otx2.
Q37066125Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex
Q46480707Retinoic acid influences the development of the inferior olivary nucleus in the rodent
Q39533288Retinoic acid influences the embryoid body formation in mouse embryonic stem cells by induction of caspase and p38 MAPK/JNK-mediated apoptosis
Q30496671Retinoic acid is a potential dorsalising signal in the late embryonic chick hindbrain
Q71975985Retinoic acid provokes metaplasia of epithelium formed in vitro by adult human epidermal keratinocytes
Q41034404Retinoic acid receptor isoform beta 2 is an early marker for alimentary tract and central nervous system positional specification in the chicken
Q37323737Retinoic acid signaling in development: tissue-specific functions and evolutionary origins.
Q43201959Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion
Q21195872Retinoic acid synthesis and functions in early embryonic development
Q41457537Retinoic acid, neoplasia, differentiation and development
Q47969876Retinoic acid-dependent upregulation of mouse folate receptor-alpha expression in embryonic stem cells, and conservation of alternative splicing patterns.
Q48054879Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis
Q45089668Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells
Q33964076Retinoid signalling and hindbrain patterning.
Q34988289Retinoid signalling in the development of the central nervous system
Q40372674Retinoids and mouse embryonic development
Q47804022Retinoids and related signals in early development of the vertebrate central nervous system.
Q47073388Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain
Q41649791Rhythm generation in the segmented hindbrain of chick embryos
Q34387368Role and distribution of retinoic acid during CNS development
Q21245642Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina).
Q28513613Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus
Q48559762Rostral truncation of a cyclostome, Lampetra japonica, induced by all-trans retinoic acid defines the head/trunk interface of the vertebrate body
Q52537224Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
Q48615111Segmental identity can change independently in the hindbrain and rhombencephalic neural crest
Q50516459Skeletal malformations associated with esophageal atresia: clinical and experimental studies.
Q52197512Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos.
Q48084654Stage and tissue-specific expression of the alcohol dehydrogenase 1 (Adh-1) gene during mouse development.
Q38742380Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke
Q41735813Structural and gene expression abnormalities induced by retinoic acid in the forebrain
Q40873851Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation.
Q33455008Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis
Q34057978The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse
Q38699953The chick embryo as a model for the effects of prenatal exposure to alcohol on craniofacial development
Q42442978The development of vestibulocochlear efferents and cochlear afferents in mice
Q40756402The effect of vitamin A (retinoids) on pattern formation implies a uniformity of developmental mechanisms throughout the animal kingdom
Q35549558The effects of light regimes and hormones on corneal growth in vivo and in organ culture
Q52078496The morphogenesis of the zebrafish eye, including a fate map of the optic vesicle.
Q38250192The neural crest: a versatile organ system.
Q52168989The previously identified r3/r5 repressor may require the cooperation of additional negative elements for rhombomere restriction of Hoxb1.
Q28208370The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function
Q28346042The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo
Q44319351The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes.
Q48270999The serotonergic phenotype is acquired by converging genetic mechanisms within the zebrafish central nervous system
Q89040890The strengths of the genetic approach to understanding neural systems development and function: Ray Guillery's synthesis
Q35197077Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogen
Q36053034Transcriptional activities of retinoic acid receptors
Q41239473Transcriptional control of Hox genes in the vertebrate nervous system
Q33674138Transformation of the cerebellum into more ventral brainstem fates causes cerebellar agenesis in the absence of Ptf1a function
Q71103015Two isoforms of Xenopus retinoic acid receptor gamma 2 (B) exhibit differential expression and sensitivity to retinoic acid during embryogenesis
Q43750223Upregulation of cellular retinoic acid-binding protein I expression by ethanol
Q35173888Vitamin A and infancy. Biochemical, functional, and clinical aspects
Q35671026Vitamin A in reproduction and development
Q49036731Vitamin A-deficient quail embryos have half a hindbrain and other neural defects
Q92486343What's retinoic acid got to do with it? Retinoic acid regulation of the neural crest in craniofacial and ocular development
Q47073778Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b

Search more.