Drug-activation of brain reward pathways

scientific article published in June 1998

Drug-activation of brain reward pathways is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0376-8716(98)00063-5
P698PubMed publication ID9716927

P2093author name stringR A Wise
P2860cites workStereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse BrainQ24617460
Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brainQ28211496
Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrainQ28303897
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
Functional architecture of basal ganglia circuits: neural substrates of parallel processingQ29618729
Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortexQ34378202
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.Q34440513
Brain dopamine and rewardQ34498922
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
Adenosine receptors and behavioral actions of methylxanthinesQ35369140
Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamineQ36004090
Opiate reward: sites and substratesQ38366638
Toward a cellular analysis of intracranial self-stimulation: contributions of collision studiesQ38715707
On the role of ascending catecholaminergic systems in intravenous self-administration of cocaineQ39725108
Catecholamine theories of reward: A critical reviewQ39759474
Neurochemistry of reward and punishment: Some implications for the etiology of schizophreniaQ40001687
The medial forebrain bundle of the rat. I. General introductionQ40087336
Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidineQ40205667
Hypothalamic substrate for the positive reinforcing properties of morphine in the ratQ40711389
The absolute refractory periods of self-stimulation neuronsQ40727005
Supersensitivity to the reinforcing effects of cocaine following 6-hydroxydopamine lesions to the medial prefrontal cortex in ratsQ41163321
Animal model for investigating the anxiogenic effects of self-administered cocaineQ41189328
6-Hydroxydopamine lesions of the medial prefrontal cortex fail to influence intravenous self-administration of cocaine.Q41245321
Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brainQ41333692
Evidence implicating descending fibers in self-stimulation of the medial forebrain bundleQ41446531
The effects of pimozide on the reinforcing efficacy of central grey stimulation in the rat.Q41473826
Intracranial self-administration of morphine into the ventral tegmental area in rats.Q52294551
Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administrationQ52301081
Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamineQ52306077
Catecholaminergic mechanisms of reinforcement: direct assessment by drug-self-administrationQ52307447
Increased Lever Pressing for Amphetamine After Pimozide in Rats: Implications for a Dopamine Theory of RewardQ52313595
Effects on self-stimulation behavior of drugs influencing dopaminergic neurotransmission mechanisms.Q52323457
Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells.Q52426698
Delta and mu enkephalins inhibit spontaneous GABA-mediated IPSCs via a cyclic AMP-independent mechanism in the rat hippocampus.Q54185578
A portrait of the substrate for self-stimulationQ57091743
Naloxone-reversible effect of opioids on pinocytosis in Amoeba proteusQ66966137
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neuronsQ66985123
The effects of delta 9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis studyQ69853528
Intracranial self-stimulation: mapping against the lateral boundaries of the dopaminergic cells of the substantia nigraQ70152293
Intracranial self-stimulation in relation to the ascending dopaminergic systems of the midbrain: a moveable electrode mapping studyQ71131880
Reinforcing effects of morphine microinjection into the ventral tegmental areaQ71277951
Glutamatergic inputs from the pedunculopontine nucleus to midbrain dopaminergic neurons in primates: Phaseolus vulgaris-leucoagglutinin anterograde labeling combined with postembedding glutamate and GABA immunohistochemistryQ71489306
GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental areaQ71610037
GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brainQ71725947
Rewarding brain stimulation: role of tegmental cholinergic neurons that activate dopamine neuronsQ72310911
Increased self-administration of d-amphetamine by rats pretreated with metergolineQ72699364
Median raphe injections of 8-OH-DPAT lower frequency thresholds for lateral hypothalamic self-stimulationQ41659719
Electrophysiological actions of nicotine on substantia nigra single unitsQ41765375
Pedunculopontine nucleus in the squirrel monkey: cholinergic and glutamatergic projections to the substantia nigraQ42491500
Intraneuronal accumulation and persistence of radiolabel in rat brain following in vivo administration of [3H]-chlorisondamineQ42707905
Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administrationQ43532092
Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotoninQ44306624
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 regionQ44335208
Dual ultrastructural localization of mu-opioid receptors and NMDA-type glutamate receptors in the shell of the rat nucleus accumbensQ44345874
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotineQ45122619
GABAA receptor-mediated inhibition of rat substantia nigra dopaminergic neurons by pars reticulata projection neurons.Q47921750
Evidence implicating both slow- and fast-conducting fibers in the rewarding effect of medial forebrain bundle stimulationQ48087278
Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats.Q48144276
Place preference conditioning with ventral tegmental injections of cytisineQ48223090
Nicotine preferentially stimulates dopamine release in the limbic system of freely moving ratsQ48264505
Trigeminal substrates of intracranial self-stimulation in the brainstemQ48298865
Conditioned place preference induced by microinjection of 8-OH-DPAT into the dorsal or median raphe nucleusQ48389948
Pimozide-induced extinction of intracranial self-stimulation: response patterns rule out motor or performance deficitsQ48402400
Pontine and mesencephalic substrates of self-stimulationQ48426712
Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neuronsQ48428303
Low doses of ethanol activate dopaminergic neurons in the ventral tegmental areaQ48435230
Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving ratsQ48453318
Studies on the distinction between uptake inhibition and release of [3H]dopamine in rat brain tissue slicesQ48465187
Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental areaQ48469772
Blockade of the reward-potentiating effects of nicotine on lateral hypothalamic brain stimulation by chlorisondamineQ48483626
Organization of amygdaloid projections to brainstem dopaminergic, noradrenergic, and adrenergic cell groups in the ratQ48513418
Hypothalamic reward mechanism: two first-stage fiber populations with a cholinergic componentQ48532124
Opioids excite dopamine neurons by hyperpolarization of local interneuronsQ48543154
Cocaine facilitation of prefrontal cortex self-stimulation: a microstructural and pharmacological analysisQ48601589
Pre- and postsynaptic inhibition by opioids in rat striatumQ48602658
Current-distance relation for rewarding brain stimulationQ48615311
Brain stimulation reward and dopamine terminal fields. I. Caudate-putamen, nucleus accumbens and amygdalaQ48682613
Conditioned place preference from intra-accumbens but not intra-caudate amphetamine injectionsQ48704069
Self-stimulation in the frontal cortex of rattus norvegicusQ48738853
Cortical dopaminergic involvement in cocaine reinforcementQ48760014
Self-injection of amphetamine directly into the brainQ48830336
Release of dopamine and 5-hydroxytryptamine from rat striatal slices following activation of nicotinic cholinergic receptorsQ48856963
Enhancement and inhibition of olfactory bulb self-stimulation by odoursQ48891151
Reinforcing effects of brain microinjections of morphine revealed by conditioned place preferenceQ48922487
Reinforcing effects of morphine in the nucleus accumbensQ48955104
Behaviorally derived measures of conduction velocity in the substrate for rewarding medial forebrain bundle stimulationQ48956129
Differential effects of atropine, procaine and dopamine in the rat ventral tegmentum on lateral hypothalamic rewarding brain stimulationQ49019982
Brain reward circuitry: four circuit elements "wired" in apparent seriesQ49023765
Brain reward circuitry: a case for separate systemsQ49023784
Opiate rewarding action: independence of the cells of the lateral hypothalamusQ49114661
Approach-avoidance analysis of rat diencephalon.Q51287332
Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area.Q51627333
MDL 72222, ketanserin, and methysergide pretreatments fail to alter breaking points on a progressive ratio schedule reinforced by intravenous cocaine.Q51674730
Antagonist treatment in nucleus accumbens or periaqueductal grey affects heroin self-administration.Q51771735
Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens.Q51876339
Habit-forming actions of nomifensine in nucleus accumbens.Q52204812
Quantitative determination of the effects of catecholaminergic agonists and antagonists on the rewarding efficacy of brain stimulation.Q52256958
P433issue1-2
P304page(s)13-22
P577publication date1998-06-01
P1433published inDrug and Alcohol DependenceQ5308875
P1476titleDrug-activation of brain reward pathways
P478volume51

Reverse relations

cites work (P2860)
Q368652505-HT1B mRNA expression after chronic social stress
Q2813910950-kHz chirping (laughter?) in response to conditioned and unconditioned tickle-induced reward in rats: effects of social housing and genetic variables
Q89807505A Neurobiological Model of Alcohol Marketing Effects on Underage Drinking
Q24537332A comparison of drug-seeking behavior maintained by D-amphetamine, L-deprenyl (selegiline), and D-deprenyl under a second-order schedule in squirrel monkeys
Q42512687A comparison of morphine-induced locomotor activity and mesolimbic dopamine release in C57BL6, 129Sv and DBA2 mice
Q34845119A dual-systems perspective on addiction: contributions from neuroimaging and cognitive training
Q46790632A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration
Q42616342A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins
Q99608450A neurobehavioral study on the efficacy of price interventions in promoting healthy food choices among low socioeconomic families
Q42728906A role for accumbal glycine receptors in modulation of dopamine release by the glycine transporter-1 inhibitor org25935.
Q36293916A scale-free systems theory of motivation and addiction
Q44666881Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats
Q36432300Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin.
Q37394343Abuse-related effects of µ-opioid analgesics in an assay of intracranial self-stimulation in rats: modulation by chronic morphine exposure
Q44891175Acquisition of MDMA self-administration: pharmacokinetic factors and MDMA-induced serotonin release
Q35988644Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake
Q37027306Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area
Q35995415Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system
Q30477757Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action
Q36311022Adult ADHD and substance abuse: diagnostic and treatment issues
Q26852192Adult hippocampal neurogenesis in the pathogenesis of addiction and dual diagnosis disorders
Q42509383Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression.
Q34465361Alcohol affects the brain's resting-state network in social drinkers
Q44853623Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findings
Q38655039Alterations in Striatal Circuits Underlying Addiction-Like Behaviors
Q28350945Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens
Q37578252Altered reward expectancy in individuals with recent methamphetamine dependence
Q36026862Amines and motivated behaviors: a simpler systems approach to complex behavioral phenomena
Q46896171An essential role for DeltaFosB in the nucleus accumbens in morphine action
Q48485540Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats
Q30433958Animal models of substance abuse and addiction: implications for science, animal welfare, and society
Q52072103Antisociality, substance dependence, and the DRD5 gene: a preliminary study.
Q39448735Arousal and drug abuse
Q48251731Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress
Q35893802Atomoxetine treatment for nicotine withdrawal: a pilot double-blind, placebo-controlled, fixed-dose study in adult smokers
Q41860629Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats
Q44593053Baclofen does not alter the reinforcing, subject-rated or cardiovascular effects of intranasal cocaine in humans
Q33815047Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand
Q47156304Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats
Q33944839Behavioral screening for cocaine sensitivity in mutagenized zebrafish
Q42927846Biphasic effects of naloxone in the rats receiving morphine overdose a place preference study
Q36746489Brain imaging demonstrates a reduced neural impact of eating in obesity
Q46440593Brain stimulation reward performance and sucrose maintained behaviors in alcohol-preferring and -nonpreferring rats
Q35684600Brain systems underlying susceptibility to helplessness and depression
Q46431176CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat.
Q48097080CNS activation by noxious heat to the hand or foot: site-dependent delay in sensory but not emotion circuitry
Q34038682CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
Q45267628CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction
Q33980198Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future
Q37612419Cannabinoid-hormone interactions in the regulation of motivational processes
Q44298237Cannabinoid-induced Fos expression within A10 dopaminergic neurons
Q44660002Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice
Q31165355Challenges and opportunities for brainstem neuroimaging with ultrahigh field MRI.
Q45272350Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice
Q38302043Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression.
Q42838148Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats
Q35689041Circadian clock genes: effects on dopamine, reward and addiction
Q50143332Clozapine's effects on ethanol's motivational properties
Q44060446Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation
Q37415367Cocaine-induced mu opioid receptor occupancy within the striatum is mediated by dopamine D2 receptors
Q24603044Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective
Q33182064Comparative analysis of the central CCK system in Fawn Hooded and Wistar Kyoto rats: extended localisation of CCK-A receptors throughout the rat brain using a novel radioligand
Q37086778Contribution of ventral tegmental GABA receptors to cocaine self-administration in rats
Q43832288Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices
Q47720163Cortico-basal ganglia circuits involved in different motivation disorders in non-human primates
Q33894614Could a common biochemical mechanism underlie addictions?
Q98189904Cytoplasmic Polyadenylation Element Binding Proteins CPEB1 and CPEB3 Regulate the Translation of FosB and Are Required for Maintaining Addiction-Like Behaviors Induced by Cocaine
Q33262178Cytosolic proteomic alterations in the nucleus accumbens of cocaine overdose victims
Q73776363D(1) dopamine receptor activation reduces GABA(A) receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade
Q44030628DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens
Q40499516Decision-making deficits and overeating: a risk model for obesity
Q24555194DeltaFosB: a sustained molecular switch for addiction
Q44878941Detection of dopamine in the presence of excess ascorbic acid at physiological concentrations through redox cycling at an unmodified microelectrode array
Q46813776Development and initial validation of a caffeine craving questionnaire
Q33625277Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessment
Q43805378Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse.
Q36024364Differential modulation of cocaine's discriminative cue by repeated and variable stress exposure: relation to monoamine transporter levels
Q28533800Differential regulation of the period genes in striatal regions following cocaine exposure
Q30981118Discrete cell gene profiling of ventral tegmental dopamine neurons after acute and chronic cocaine self-administration.
Q36682362Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse
Q46419882Dissociation between rewarding and psychomotor effects of opiates: differential roles for glutamate receptors within anterior and posterior portions of the ventral tegmental area.
Q36913451Divergent effects of D₂/₃ receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats
Q48456185Dopamine D(2) receptor modulation of K(+) channel activity regulates excitability of nucleus accumbens neurons at different membrane potentials
Q42518694Dopamine D2 receptor as a cellular component controlling nocturnal hyperactivities in Drosophila melanogaster
Q30491317Dopamine modulation of emotional processing in cortical and subcortical neural circuits: evidence for a final common pathway in schizophrenia?
Q37087395Dopamine receptors in human lymphocytes: radioligand binding and quantitative RT-PCR assays
Q29616245Dopamine, learning and motivation
Q56553444Drug use and addiction: evolutionary perspective
Q34098282Drug- and cue-induced reinstatement of cannabinoid-seeking behaviour in male and female rats: influence of ovarian hormones.
Q37823697Drug-sensitive reward in crayfish: an invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal
Q48567232Drugs of abuse specifically sensitize noradrenergic and serotonergic neurons via a non-dopaminergic mechanism
Q36942175Dynorphin and the pathophysiology of drug addiction
Q33898069Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder
Q34764672Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.
Q44377050Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin as a function of alcohol intake, age, and gender
Q42861371Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats
Q44341600Effect of strain and sex on mu opioid receptor-mediated G-protein activation in rat brain.
Q36650320Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens
Q50910134Effects of conditioned reward and nonreward cues on the heart rate response to alcohol intoxication in male social drinkers.
Q46029912Effects of delta9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress.
Q43557506Effects of dopamine antagonists with different receptor blockade profiles on morphine-induced place preference in male mice
Q36478952Effects of gestational exposure to methylmercury and dietary selenium on reinforcement efficacy in adulthood
Q44344204Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats
Q103836625Effects of long-term cocaine self-administration on brain resting-state functional connectivity in nonhuman primates
Q48436522Effects of short-term abstinence from escalating doses of D-amphetamine on drug and sucrose-evoked dopamine efflux in the rat nucleus accumbens
Q44736250Effects of the dopamine reuptake inhibitor PTT on reinstatement and on food- and cocaine-maintained responding in rhesus monkeys
Q35748384Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys
Q44193492Effects of the selective mu(1)-opioid receptor antagonist, naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in rats
Q30441589Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals
Q44289692Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat.
Q34359778Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell.
Q44223042Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area
Q34985814Enhanced Extracellular Glutamate and Dopamine in the Ventral Pallidum of Alcohol-Preferring AA and Alcohol-Avoiding ANA Rats after Morphine
Q44066984Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine.
Q36137339Enhanced sensitivity to naltrexone-induced drinking suppression of fluid intake and sucrose consumption in maternally separated rats
Q31646659Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons.
Q50776931Ethanol pre-exposure during adolescence or adulthood increases ethanol intake but ethanol-induced conditioned place preference is enhanced only when pre-exposure occurs in adolescence.
Q44494851Evidence of increased dopamine receptor signaling in food-restricted rats
Q43236074Evidence of long-term expression of behavioral sensitization to both cocaine and ethanol in dopamine transporter knockout mice
Q51401016Evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward.
Q49274004Evolutionary Considerations on the Emerging Subculture of the E-psychonauts and the Novel Psychoactive Substances: A Comeback to the Shamanism?
Q44658138Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats
Q33875193Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine
Q35909931Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration
Q44462778Extracellular levels of dopamine in the nucleus accumbens in AA and ANA rats after reverse microdialysis of ethanol into the nucleus accumbens or ventral tegmental area
Q34093911Extrasynaptic distribution of monoamine transporters and receptors
Q43966013Fermenting fruit and the historical ecology of ethanol ingestion: is alcoholism in modern humans an evolutionary hangover?
Q34982313From neurobiology to treatment: progress against addiction
Q85236567GABAA receptors in VTA mediate the morphine-induced release of ascorbic acid in rat nucleus accumbens
Q36405967GABAB receptor activation attenuates the stimulant but not mesolimbic dopamine response to ethanol in FAST mice
Q36952331Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism
Q34076144Genes and addiction
Q36409468Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol
Q44465604Glutamate motivational ensembles in nucleus accumbens: rostrocaudal shell gradients of fear and feeding
Q22251224Hallucinogens
Q36641847Hedonic hot spots in the brain.
Q45711539Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro.
Q33693354History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine
Q43591899Immunohistochemical characterisation of Fos-positive cells in brainstem monoaminergic nuclei following intracranial self-stimulation of the medial forebrain bundle in the rat.
Q39506736Impaired executive control and reward circuit in Internet gaming addicts under a delay discounting task: independent component analysis
Q41288556Implications of Circadian Rhythm in Dopamine and Mood Regulation
Q44423347Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior
Q35809710Inactivation of the central nucleus of the amygdala reduces the effect of punishment on cocaine self-administration in rats
Q44330916Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission
Q45133907Increased fasting plasma ghrelin levels during alcohol abstinence
Q33619864Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats.
Q33949384Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens
Q44410508Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine
Q30431946Influence of reinforcer magnitude and nicotine amount on smoking's acute reinforcement enhancing effects
Q43867256Inhibition of cocaine self-administration by fluoxetine or D-fenfluramine combined with phentermine
Q34794541Interaction between glucocorticoid hormones, stress and psychostimulant drugs
Q34098160Interactions between medial prefrontal cortex and meso-limbic components of brain reward circuitry
Q44755323Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons.
Q35788421Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine
Q33845750Intracranial self-stimulation to evaluate abuse potential of drugs.
Q44176750Involvement of dopamine D2 receptors of the central amygdala on the acquisition and expression of morphine-induced place preference in rat.
Q44325760Juvenile drug offenders who use amphetamine recommitted to a remand center: the role of psychiatric morbidity
Q41639865Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials
Q41654778Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids
Q48961392Learning about addiction from the genome
Q43593941Leptin: a modulator of alcohol craving?
Q48406762Lesions of basolateral amygdala impair extinction of CS motivational value, but not of explicit conditioned responses, in Pavlovian appetitive second-order conditioning
Q45049926Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption
Q34738758Like drugs for chocolate: separate rewards modulated by common mechanisms?
Q34100505Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine
Q34714823MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats
Q39041476Maladaptive Sexual Behavior Following Concurrent Methamphetamine and Sexual Experience in Male Rats is Associated with Altered Neural Activity in Frontal Cortex
Q43263536Maternal separation fails to render animals more susceptible to methamphetamine-induced conditioned place preference
Q24234801Media Campaigns for the prevention of illicit drug use in young people
Q24202193Media campaigns for the prevention of illicit drug use in young people
Q44653396Mediation of Amphetamine-Induced Long-Term Depression of Synaptic Transmission by CB1Cannabinoid Receptors in the Rat Amygdala
Q33608570Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates
Q37147049Methylphenidate enhances the abuse-related behavioral effects of nicotine in rats: intravenous self-administration, drug discrimination, and locomotor cross-sensitization
Q37377937Milk consumption during adolescence decreases alcohol drinking in adulthood
Q42374658Modeling Causal Relationships among Brain Areas in the Mesocorticolimbic System during Resting-State in Cocaine Users Utilizing a Graph Theoretic Approach
Q30478692Modulation of glutamatergic synaptic transmission in the bed nucleus of the stria terminalis
Q52166599Modulation of long-term depression by dopamine in the mesolimbic system.
Q29620539Molecular basis of long-term plasticity underlying addiction
Q35033013Monitoring rapid chemical communication in the brain.
Q48435754Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens
Q43517475Motivational effects of ethanol in DARPP-32 knock-out mice.
Q34056092Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: an animal model of dual diagnosis schizophrenia
Q27022465Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine
Q43798717Naltrexone suppresses ethanol intake in 6-hydroxydopamine-treated rats
Q30371463Neonatal exposure to amphetamine alters social affiliation and central dopamine activity in adult male prairie voles
Q34172647Neonatal maternal separation exacerbates the reward-enhancing effect of acute amphetamine administration and the anhedonic effect of repeated social defeat in adult rats
Q57793709Neural Circuit Motifs in Valence Processing
Q41910628Neural events in the reinforcement contingency
Q34519362Neural substrates of conditioned-cued relapse to drug-seeking behavior
Q35758824Neurobehavioral assessment in the information age.
Q29619932Neurobiology of depression
Q35164057Neurodevelopmental liabilities in alcohol dependence: central serotonin and dopamine dysfunction
Q35692967Neuroimaging and mechanisms of drug abuse: interface of molecular imaging and molecular genetics
Q36441387Neuronal substrates of relapse to cocaine-seeking behavior: role of prefrontal cortex
Q44327688New neuronal networks involved in ethanol reinforcement
Q46937479Nicotine increases dopamine clearance in medial prefrontal cortex in rats raised in an enriched environment
Q35591662Nicotinic acetylcholine receptors containing α6 subunits contribute to alcohol reward-related behaviours
Q34040222Nociceptin/orphanin FQ and drugs of abuse
Q37336909Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure.
Q37275277Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults.
Q55254470Nucleus Accumbens Microcircuit Underlying D2-MSN-Driven Increase in Motivation.
Q36858644Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma
Q34738746Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement
Q51399828Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats.
Q48267409Obese adults have visual attention bias for food cue images: evidence for altered reward system function
Q44366019Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm
Q46624957Olanzapine-induced suppression of cocaine self-administration in rhesus monkeys
Q47301293On Mourning and Recovery: Integrating Stages of Grief and Change Toward a Neuroscience-Based Model of Attachment Adaptation in Addiction Treatment.
Q48914679Opioidergic modulation of ethanol self-administration in the ventral pallidum
Q37994954Optogenetic investigation of neural circuits underlying brain disease in animal models.
Q48237635Origins and import of reinforcing self-stimulation of the brain
Q40765503Overexpression of BDNF in the ventral tegmental area enhances binge cocaine self-administration in rats exposed to repeated social defeat.
Q34107653Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment
Q28190901Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent
Q28140910Pain responses in methadone-maintained opioid abusers
Q35007416Pathobiology of dynorphins in trauma and disease
Q26771407Pedunculopontine arousal system physiology-Effects of psychostimulant abuse
Q37193875Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating
Q44156439Place conditioning: what does it add to our understanding of ethanol reward?
Q35073513Plasticity of addiction: a mesolimbic dopamine short-circuit?
Q35156987Pleasures of the brain
Q44102469Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste "liking"/"disliking" reactions, place preference/avoidance, and fear.
Q36357574Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism.
Q34934319Preclinical models: status of basic research in depression
Q35545708Preference for cocaine- versus pup-associated cues differentially activates neurons expressing either Fos or cocaine- and amphetamine-regulated transcript in lactating, maternal rodents
Q34424490Prefrontal cortex and drug abuse vulnerability: translation to prevention and treatment interventions.
Q44987797Previous exposure to psychostimulants enhances the reinstatement of cocaine seeking by nucleus accumbens AMPA.
Q34405077Psychogenomics: opportunities for understanding addiction.
Q42443389RGS9 modulates dopamine signaling in the basal ganglia
Q35652613Rapid neuroadaptation in the nucleus accumbens and bed nucleus of the stria terminalis mediates suppression of operant responding during withdrawal from acute opioid dependence
Q50067452Real-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial.
Q44977130Recent advances in cyclic-adenosine monophosphate/protein kinase A signaling in ethanol-induced synaptic and behavioral alterations
Q34665471Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction
Q36059914Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism
Q44668411Reduced cardiovascular effects of methamphetamine following treatment with selegiline
Q44423342Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice
Q33852098Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
Q30428258Reinforcement enhancing effects of nicotine via smoking
Q37705218Relationship between alcohol dependence, escape drinking, and early neural attention to alcohol-related cues.
Q34392594Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine
Q37387756Repeated Cocaine Experience Facilitates Sucrose-Reinforced Operant Responding in Enriched and Isolated Rats
Q44929738Repetitive transcranial magnetic stimulation increases the release of dopamine in the nucleus accumbens shell of morphine-sensitized rats during abstinence.
Q37101691Resilience in mental health: linking psychological and neurobiological perspectives
Q50783561Responsiveness to reward following cessation of smoking.
Q36805098Reversal effect of intra-central amygdala microinjection of L-arginine on place aversion induced by naloxone in morphine conditioned rats
Q42665192Reward circuitry activation by noxious thermal stimuli
Q48233967Reward-associated gamma oscillations in ventral striatum are regionally differentiated and modulate local firing activity
Q35671426Role for GDNF in biochemical and behavioral adaptations to drugs of abuse.
Q48535512Role for ventral pallidal GABAergic mechanisms in the regulation of ethanol self-administration
Q28082885Role of NG2 expressing cells in addiction: a new approach for an old problem
Q41706900Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats.
Q38891009Role of perineuronal nets in the anterior dorsal lateral hypothalamic area in the acquisition of cocaine-induced conditioned place preference and self-administration
Q34122658Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine
Q26782608Role of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms
Q37394355Role of µ-opioid receptor reserve and µ-agonist efficacy as determinants of the effects of µ-agonists on intracranial self-stimulation in rats
Q34401390Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse.
Q42138992Selective D3 Receptor Antagonist SB-277011-A Potentiates the Effect of Cocaine on Extracellular Dopamine in the Nucleus Accumbens: a Dual Core-Shell Voltammetry Study in Anesthetized Rats
Q44681125Selective encoding of cocaine versus natural rewards by nucleus accumbens neurons is not related to chronic drug exposure.
Q44385237Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study
Q37386501Shared mechanisms of alcohol and other drugs
Q30360185Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats.
Q24610390Smoking is associated with worse mood on stressful days: results from a national diary study
Q48649456Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model
Q35623042Some determinants of morphine effects on intracranial self-stimulation in rats: dose, pretreatment time, repeated treatment, and rate dependence
Q42271158Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania
Q35581499Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice
Q36210642Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity
Q37124698Stress, alcohol and drug interaction: an update of human research
Q48490423Striatal dopamine release and family history of alcoholism
Q37217098Subcortical volumes are reduced in short-term and long-term abstinent alcoholics but not those with a comorbid stimulant disorder
Q34990269Subcortical volumes in long-term abstinent alcoholics: associations with psychiatric comorbidity
Q44398175Subsecond dopamine release promotes cocaine seeking.
Q30432649Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction
Q44520682Suppression of morphine-induced conditioned place preference by l-12-chloroscoulerine, a novel dopamine receptor ligand
Q37037238The D2 dopamine receptor gene and nicotine dependence among bladder cancer patients and controls
Q47113353The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse
Q42461221The Type IV phosphodiesterase inhibitor rolipram interferes with drug-induced conditioned place preference but not immediate early gene induction in mice
Q38875939The abuse liability of the NMDA receptor antagonist-benzodiazepine (tiletamine-zolazepam) combination: evidence from clinical case reports and preclinical studies
Q51402700The activity-regulated cytoskeletal-associated protein arc is expressed in different striosome-matrix patterns following exposure to amphetamine and cocaine.
Q36589457The alcohol-preferring AA and alcohol-avoiding ANA rats: neurobiology of the regulation of alcohol drinking
Q34661215The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life
Q44317518The effect of neurotoxic doses of methamphetamine on methamphetamine-conditioned place preference in rats
Q44451570The effects of antidepressant treatment on serotonergic and dopaminergic systems in Fawn-Hooded rats: a quantitative autoradiography study
Q51972404The effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats.
Q43886062The effects of ventral tegmental administration of GABA(A), GABA(B), NMDA and AMPA receptor agonists on ventral pallidum self-stimulation
Q30475613The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents.
Q36085080The genetics of depression and related traits
Q37142046The impact of early environmental rearing condition on the discriminative stimulus effects and Fos expression induced by cocaine in adult male and female rats
Q30957200The neural circuitry of reward and its relevance to psychiatric disorders
Q35064092The neurobiology of depression: perspectives from animal and human sleep studies
Q37253618The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models
Q34088740The psychopharmacology of tachykinin NK-3 receptors in laboratory animals
Q35718099The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice
Q34522538The role of brain emotional systems in addictions: a neuro-evolutionary perspective and new 'self-report' animal model.
Q90110607The role of oxytocin in alcohol and drug abuse
Q34612112The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence.
Q34268488The role of the brain reward system in depression
Q37164027The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats
Q42944613Trait-like impulsivity does not predict escalation of heroin self-administration in the rat.
Q36462714Translation in tobacco and drug abuse prevention research
Q36228225Treatment of substance use disorders in schizophrenia: a unifying neurobiological mechanism?
Q48556363Two brain sites for cannabinoid reward.
Q58796015Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects
Q93196767Using Ca2+-channel biosensors to profile amphetamines and cathinones at monoamine transporters: electro-engineering cells to detect potential new psychoactive substances
Q48608961Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats
Q34945454Voucher-based incentives. A substance abuse treatment innovation.
Q44437771WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation

Search more.