Recycling of MUC1 is dependent on its palmitoylation.

scientific article published on 28 February 2006

Recycling of MUC1 is dependent on its palmitoylation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M512996200
P698PubMed publication ID16507569
P5875ResearchGate publication ID7269386

P2093author name stringOssama B Kashlan
Carol L Kinlough
Rebecca P Hughey
James B Bruns
Ora A Weisz
Paul A Poland
Keri L Harkleroad
Kelly M Weixel
Rebecca J McMahan
Richard J Stremple
P2860cites workEpisialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix componentsQ24312497
Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-cateninQ24522854
The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequenceQ24523815
Fatty acid modification of the coxsackievirus and adenovirus receptorQ24537668
Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation stateQ24548387
Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behaviorQ24564534
Human VPS34 is required for internal vesicle formation within multivesicular endosomesQ24652429
Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomesQ24671322
The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferaseQ24672871
Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae.Q27931414
The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusionQ27934671
Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivoQ27939571
The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-cateninQ28142359
MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasionQ28180863
Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cellsQ28203249
Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signalingQ28205083
Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membraneQ28206954
Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary glandQ28208406
The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-cateninQ28210439
Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesionQ28237260
DCC association with lipid rafts is required for netrin-1-mediated axon guidanceQ28243669
Model systems, lipid rafts, and cell membranesQ28261365
Palmitoylation of intracellular signaling proteins: regulation and functionQ28266189
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activationQ28281516
Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residuesQ28285568
Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residuesQ28583232
c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor functionQ30303639
Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profilesQ33217688
MUC1: the polymorphic appearance of a human mucinQ33891616
Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphologyQ34011703
Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts).Q34088700
Palmitoylation of carboxypeptidase D. Implications for intracellular traffickingQ34184352
Role of the cytoplasmic domain of the Newcastle disease virus fusion protein in association with lipid raftsQ34227014
The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literatureQ34273106
Palmitoylation of the murine leukemia virus envelope protein is critical for lipid raft association and surface expressionQ34359777
Palmitoylation of claudins is required for efficient tight-junction localizationQ34403266
Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines. Demonstration of simpler and fewer glycan chains in tumor cells.Q34411297
Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agentsQ34440814
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.Q34442292
Resistance of cell membranes to different detergentsQ35022104
The on-off story of protein palmitoylationQ35024829
Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor functionQ35031239
New insights into the mechanisms of protein palmitoylation.Q35106582
Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factorsQ35291650
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progressionQ35679187
On the mechanism of protein palmitoylationQ35936412
Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblastsQ36219903
AP-2-containing clathrin coats assemble on mature lysosomesQ36257719
Palmitoylation supports assembly and function of integrin-tetraspanin complexesQ36322840
The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZQ36631283
LMP2A does not require palmitoylation to localize to buoyant complexes or for functionQ37567931
In vitro formation of recycling vesicles from endosomes requires adaptor protein-1/clathrin and is regulated by rab4 and the connector rabaptin-5.Q37595151
CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4.Q38348905
Dynamin-dependent transferrin receptor recycling by endosome-derived clathrin-coated vesiclesQ39354587
Palmitoylation, membrane-proximal basic residues, and transmembrane glycine residues in the reovirus p10 protein are essential for syncytium formationQ39996417
A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1.Q40242537
The MUC1 SEA module is a self-cleaving domain.Q40403573
Acylation-mediated membrane anchoring of avian influenza virus hemagglutinin is essential for fusion pore formation and virus infectivityQ40429726
Palmitoylation is not required for trafficking of human anion exchanger 1 to the cell surfaceQ40613060
Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylationQ40737579
Enzymatic depalmitoylation of viral glycoproteins with acyl-protein thioesterase 1 in vitroQ40781982
Association of MUC-1 and SPGL-1 with low-density microdomain in T-lymphocytes: a preliminary noteQ40792596
Human immunodeficiency virus type 1 envelope glycoproteins that lack cytoplasmic domain cysteines: impact on association with membrane lipid rafts and incorporation onto budding virus particlesQ40815042
Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane.Q40855892
Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.Q40977491
Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sortingQ41233270
The epithelial mucin MUC1 contains at least two discrete signals specifying membrane localization in cellsQ41237208
Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells.Q41282220
Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolaeQ41358613
A novel class of clathrin-coated vesicles budding from endosomesQ41811118
Proteolytic processing of sulfated secretogranin II in the trans-Golgi network of GH3B6 prolactin cellsQ41929080
Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules.Q42831894
Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomesQ44097413
Endocytosed transferrin receptors recycle via distinct dynamin and phosphatidylinositol 3-kinase-dependent pathwaysQ44174349
Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signalingQ44272110
Palmitoylation regulates the clustering and cell surface stability of GABAA receptorsQ44945098
MUC1 membrane trafficking is modulated by multiple interactionsQ45096221
Palmitoylation and intracellular domain interactions both contribute to raft targeting of linker for activation of T cellsQ45308847
Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein associationQ46331290
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucinQ46862287
VIP17/MAL, a proteolipid in apical transport vesicles.Q48068225
Maturation of the epithelial Na+ channel involves proteolytic processing of the alpha- and gamma-subunitsQ48824788
Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin.Q52551167
Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.Q54067088
Essential Role of CD8 Palmitoylation in CD8 Coreceptor FunctionQ57275513
Lipid-dependent Targeting of G Proteins into RaftsQ57371836
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)12112-12122
P577publication date2006-02-28
P1433published inJournal of Biological ChemistryQ867727
P1476titleRecycling of MUC1 is dependent on its palmitoylation.
P478volume281

Reverse relations

cites work (P2860)
Q34365646Altered Mucins (MUC) trafficking in benign and malignant conditions
Q38038634Continuous endocytic recycling of tight junction proteins: how and why?
Q28727361Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells
Q35604269Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal
Q34155244Cys Palmitoylation of the β Subunit Modulates Gating of the Epithelial Sodium Channel
Q33733493Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands
Q33916855Endosomal recycling regulates Anthrax Toxin Receptor 1/Tumor Endothelial Marker 8-dependent cell spreading.
Q41506874Evidence for core 2 to core 1 O-glycan remodeling during the recycling of MUC1.
Q26739942Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling)
Q34675709Identification and characterization of endogenous galectins expressed in Madin Darby canine kidney cells.
Q92659263Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma
Q49787431Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration
Q37866316Lipid rafts: signaling and sorting platforms of cells and their roles in cancer
Q42579174MUC1 as a Putative Prognostic Marker for Prostate Cancer
Q41763531MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism
Q36761932MUC1 traverses apical recycling endosomes along the biosynthetic pathway in polarized MDCK cells
Q36753508MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches
Q38373190MUC1-mediated motility in breast cancer: a review highlighting the role of the MUC1/ICAM-1/Src signaling triad
Q33944507Membrane-tethered mucins have multiple functions on the ocular surface.
Q33403662Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells
Q24633765Mucins in cancer: function, prognosis and therapy
Q39378500Novel roles for mucin 1 in the kidney
Q40133198Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.
Q39832097Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha
Q37351642Palmitoylation of membrane proteins (Review).
Q34604889Palmitoylation-dependent protein sorting.
Q33915087Palmitoylation: a protein S-acylation with implications for breast cancer
Q47239374Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
Q35747225Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications
Q37712756S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment
Q89996678Sequence-Specific Mucins for Glycocalyx Engineering
Q36761968Sorting It Out in Endosomes: An Emerging Concept in Renal Epithelial Cell Transport Regulation
Q24299903The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine
Q37359993The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review).
Q27014134The physiology of protein S-acylation
Q38913048Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications
Q34575170Trafficking and signaling by fatty-acylated and prenylated proteins
Q33814910Trafficking to the apical and basolateral membranes in polarized epithelial cells

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