PGE2 /EP4 receptor attenuated mucosal injury via β-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy.

scientific article published on 18 February 2017

PGE2 /EP4 receptor attenuated mucosal injury via β-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BPH.13752
P932PMC publication ID5386997
P698PubMed publication ID28213942

P50authorBin WuQ51132574
P2093author name stringYu Lu
Jie Jiang
Xiaoli Huang
Xiaoliang Chen
Huiling Liu
Minyi Xu
Siwei Tan
Xiaojie Peng
P2860cites workPhysiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidneyQ26771378
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The Prostaglandin E2 Receptor, EP2, Stimulates Keratinocyte Proliferation in Mouse Skin by G Protein-dependent and β-Arrestin1-dependent Signaling PathwaysQ34400793
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancerQ34421001
Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy?Q34527552
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Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human MacrophagesQ35612957
β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation.Q36619784
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PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy.Q37680278
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Insulin-Like Growth Factor-1 Contributes to Mucosal Repair by β-Arrestin2-Mediated Extracellular Signal-Related Kinase Signaling in Experimental Colitis.Q38835925
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Prostaglandin E2 downregulates TNF-alpha-induced production of matrix metalloproteinase-1 in HCS-2/8 chondrocytes by inhibiting Raf-1/MEK/ERK cascade through EP4 prostanoid receptor activationQ40221802
Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation siteQ40601716
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Inhibition of Src kinase blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice.Q42936581
Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptorsQ43002209
Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive ratsQ43294876
Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signalsQ46045421
β-Arrestin-1 protects against endoplasmic reticulum stress/p53-upregulated modulator of apoptosis-mediated apoptosis via repressing p-p65/inducible nitric oxide synthase in portal hypertensive gastropathyQ85485775
Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and AktQ85622475
Portal hypertensive gastropathy and gastric antral vascular ectasiaQ86172611
Arrestin interaction with E3 ubiquitin ligases and deubiquitinases: functional and therapeutic implicationsQ86870983
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)848-866
P577publication date2017-03-25
P1433published inBritish Journal of PharmacologyQ919631
P1476titlePGE2 /EP4 receptor attenuated mucosal injury via β-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy.
P478volume174

Reverse relations

cites work (P2860)
Q90467644IL-6-driven FasL promotes NF-κBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy
Q89524355The peripheral CB1 receptor antagonist JD5037 attenuates liver fibrosis via a CB1 receptor/β-arrestin1/Akt pathway

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