Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome.

scientific article

Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1541-7786.MCR-09-0511
P932PMC publication ID2855782
P698PubMed publication ID20353998

P50authorJae KimQ42798668
P2093author name stringYehia Daaka
Nicole Frilot
Vijayabaskar Lakshmikanthan
P2860cites workBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexesQ22008730
PTP1B contributes to the oncogenic properties of colon cancer cells through Src activationQ24299152
Celecoxib for the prevention of colorectal adenomatous polypsQ28200375
Prostaglandin E synthaseQ28214892
Cyclooxygenases 1 and 2Q29615645
Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2.Q30855607
Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cellsQ33356757
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.Q34108525
Role of beta-arrestin 1 in the metastatic progression of colorectal cancerQ34335080
Coxibs and cardiovascular diseaseQ34356732
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.Q34536660
Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptorQ34548751
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptorQ34562493
Effect of celecoxib on cardiovascular events and blood pressure in two trials for the prevention of colorectal adenomasQ34570463
Targeting the mitogen-activated protein kinase cascade to treat cancerQ35968411
Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitizationQ36604354
NSAIDs and cancer prevention: targets downstream of COX-2.Q36651702
Cyclooxygenases, prostanoids, and tumor progressionQ36925833
Lipid signalling in disease.Q37064018
Cyclooxygenase-2 inhibitors in colorectal cancer prevention: pointQ37245575
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironmentQ37366259
Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cellsQ39840354
Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2.Q39876429
Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells.Q39882197
Prostaglandin E2 stimulates human lung carcinoma cell growth through induction of integrin-linked kinase: the involvement of EP4 and Sp1.Q39889975
Soluble EP2 neutralizes prostaglandin E2-induced cell signaling and inhibits osteolytic tumor growthQ39940114
The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cellsQ40107119
Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells.Q40151992
Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonismQ40223997
Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independenceQ40304135
Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxiaQ40365100
Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner.Q40396797
Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma).Q40402766
Altered pain perception and inflammatory response in mice lacking prostacyclin receptorQ40646776
Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancerQ40780797
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cellsQ42164683
FDA advisers warn: COX 2 inhibitors increase risk of heart attack and strokeQ42855511
Prostaglandin E2 increases growth and motility of colorectal carcinoma cellsQ43559615
Prostaglandin E2 reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP3.Q43984203
The relationship between cyclooxygenase-2 expression and colorectal cancer.Q44193470
Dimethyl celecoxib as a novel non-cyclooxygenase 2 therapy in the treatment of non-small cell lung cancerQ46497910
The ups and downs of SRC regulation: tumor suppression by Cbp.Q46552286
Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis.Q51825086
Cyclooxygenase-2 (COX-2) mRNA expression levels in normal lung tissues and non-small cell lung cancers.Q53413842
COX-2 inhibitors, other NSAIDs, and cardiovascular risk: the seduction of common sense.Q55042437
Prognostic significance of elevated cyclooxygenase-2 expression in breast cancerQ77601963
P433issue4
P921main subjectlung cancerQ47912
prostaglandin E2Q416554
P304page(s)569-577
P577publication date2010-03-30
P1433published inMolecular Cancer ResearchQ2751014
P1476titleProstaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome
P478volume8

Reverse relations

cites work (P2860)
Q269978095-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis
Q47100323Activation of PGE2/EP2 and PGE2/EP4 signaling pathways positively regulate the level of PD-1 in infiltrating CD8+ T cells in patients with lung cancer
Q36003618Acute activation of β2-adrenergic receptor regulates focal adhesions through βArrestin2- and p115RhoGEF protein-mediated activation of RhoA.
Q33791932Alterations in lipid mediated signaling and Wnt/ β -catenin signaling in DMH induced colon cancer on supplementation of fish oil.
Q39003091An EP4 antagonist ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer
Q55239965Arachidonic acid-induced Ca2+ entry and migration in a neuroendocrine cancer cell line.
Q92108851Bioinformatics analysis of microarray data to identify the candidate biomarkers of lung adenocarcinoma
Q51703393COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis.
Q38923338CYP2S1 depletion enhances colorectal cell proliferation is associated with PGE2-mediated activation of β-catenin signaling
Q33564023Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
Q100949984Common Mechanistic Pathways in Cancer and Heart Failure
Q57052675Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT-116 cells through down-regulation of prostaglandin E2 receptor EP4
Q35838020Cyclooxygenase-2, a Potential Therapeutic Target, Is Regulated by miR-101 in Esophageal Squamous Cell Carcinoma.
Q34224752Cyclooxygenases and lipoxygenases in cancer
Q40852202Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model
Q36335457Cytochrome P450 2S1 depletion enhances cell proliferation and migration in bronchial epithelial cells, in part, through modulation of prostaglandin E(2) synthesis
Q60043877Dihomo-γ-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase
Q36444308Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis
Q36340442EP1 disruption attenuates end-organ damage in a mouse model of hypertension
Q38720995EP4 receptor promotes invadopodia and invasion in human breast cancer
Q40854700Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition
Q34666257Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE₂-mediated activation of β-catenin signaling
Q90762243Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer
Q35641880Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways
Q99239658Inhibition of PI3K-AKT Signaling Blocks PGE2-Induced COX-2 Expression in Lung Adenocarcinoma
Q38053088Involvement of β-arrestins in cancer progression
Q26850218Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention
Q37046835MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2.
Q38459674Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling
Q37701635Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer
Q35049578Mycophenolic acid inhibits migration and invasion of gastric cancer cells via multiple molecular pathways
Q43520637Nicotine induces EP4 receptor expression in lung carcinoma cells by acting on AP-2α: The intersection between cholinergic and prostanoid signaling
Q35879417Novel link between prostaglandin E2 (PGE2) and cholinergic signaling in lung cancer: The role of c-Jun in PGE2-induced α7 nicotinic acetylcholine receptor expression and tumor cell proliferation
Q33695021Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification
Q51132517PGE2 /EP4 receptor attenuated mucosal injury via β-arrestin1/Src/EGFR-mediated proliferation in portal hypertensive gastropathy.
Q33761715PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells
Q37470737Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties
Q37366238Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer
Q36806255Prostaglandin E2 EP receptors as therapeutic targets in breast cancer
Q37908321Prostaglandin E2 modulation of blood pressure homeostasis: studies in rodent models
Q35713568Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions
Q35311177Prostaglandin E2 regulates renal cell carcinoma invasion through the EP4 receptor-Rap GTPase signal transduction pathway
Q36424854Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis
Q38759898Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells
Q64932507Prostaglandin E2 triggers cytochrome P450 17α hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.
Q38701133Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells
Q50082353Prostaglandin receptors induce urothelial tumourigenesis as well as bladder cancer progression and cisplatin resistance presumably via modulating PTEN expression.
Q39640064RETRACTED: Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2and prostaglandin E2receptors
Q35871610Rap1GAP regulates renal cell carcinoma invasion
Q38473314Regulatory T cells and potential inmmunotherapeutic targets in lung cancer
Q34055550Retracted: Green Tea Catechins Reduce Invasive Potential of Human Melanoma Cells by Targeting COX-2, PGE2 Receptors and Epithelial-to-Mesenchymal Transition
Q39078274Silymarin suppresses the PGE2 -induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways
Q36771000TGF-β effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway
Q34400793The Prostaglandin E2 Receptor, EP2, Stimulates Keratinocyte Proliferation in Mouse Skin by G Protein-dependent and β-Arrestin1-dependent Signaling Pathways
Q47328865The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review).
Q36622079Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis
Q89358557Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative
Q26740489β-arrestin1 at the cross-road of endothelin-1 signaling in cancer
Q34589698βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer
Q33676791βArrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility

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