Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes.

scientific article published in May 2012

Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00125-012-2459-7
P698PubMed publication ID22286551
P5875ResearchGate publication ID221788196

P50authorJens Juul HolstQ28373106
Sten MadsbadQ39034312
Jan Erik HenriksenQ39438302
Benjamin A. H. JensenQ40143669
P2093author name stringA Vølund
K Aaboe
T Krarup
P2860cites workTissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humansQ27865308
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Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?Q33803409
Report of the expert committee on the diagnosis and classification of diabetes mellitusQ34167177
Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginineQ34180164
Accurate assessment of beta-cell function: the hyperbolic correctionQ34508795
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetesQ35085591
Nutrient, neural and endocrine control of glucagon-like peptide secretionQ36012464
Glucagon-like peptide-1, glucose homeostasis and diabetesQ37114343
Immunoassays for the incretin hormones GIP and GLP-1.Q37595932
Banting lecture 1990. Beta-cells in type II diabetes mellitusQ37633379
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Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*Q40329405
Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitusQ40337480
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjectsQ42436041
Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humansQ42512452
Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patientsQ44110180
Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance testQ44251909
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysisQ45105931
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetesQ45112803
Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetesQ46739343
Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patientsQ46830628
Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose toleranceQ46944971
Critical evaluation of the 'heated-hand-technique' for obtaining 'arterialized' venous blood: incomplete arterialization and alterations in glucagon responsesQ48757055
Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects.Q51387579
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.Q51561183
Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.Q51571637
Proinsulin as a marker for the development of NIDDM in Japanese-American men.Q51590740
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.Q51598262
Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies.Q51598705
Effect of hypercorticism on regulation of skeletal muscle glycogen metabolism by epinephrineQ51606171
Validation of methods for measurement of insulin secretion in humans in vivo.Q52077029
Risk and mechanism of dexamethasone-induced deterioration of glucose tolerance in non-diabetic first-degree relatives of NIDDM patients.Q54148814
Mechanisms of dexamethasone-induced insulin resistance in healthy humans.Q54193481
Reduced Incretin Effect in Type 2 DiabetesQ58168459
Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitusQ58168509
Evaluation of beta-cell secretory capacity using glucagon-like peptide 1Q58169163
Diminished Immunoreactive Gastric Inhibitory Polypeptide Response to a Meal in Newly Diagnosed Type I (Insulin-Dependent) Diabetics*Q58169791
The heterogeneity of gastric inhibitory polypeptide in porcine and human gastrointestinal mucosa evaluated with five different antiseraQ58449428
Glucagon-related peptides in the human gastrointestinal mucosaQ58449435
Circulating glucagon after total pancreatectomy in manQ58449447
Hyperproinsulinemia in type II diabetesQ68032837
Reduced incretin effect in type 2 (non-insulin-dependent) diabetesQ68865252
Basal and stimulated hyperinsulinism: reversible metabolic sequelae of obesityQ69743827
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responsesQ93538767
P433issue5
P921main subjectinsulin resistanceQ1053470
type 2 diabetesQ3025883
preproinsulinQ7240673
P304page(s)1406-1416
P577publication date2012-05-01
P1433published inDiabetologiaQ5270140
P1476titleSteroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes.
P478volume55

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