| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Ambuj Kumar | |
| Rituraj Purohit | |||
| Rao Sethumadhavan | |||
| Vidya Rajendran | |||
| P2860 | cites work | Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways | Q56998115 |
| A novel loss-of-function mutation (N48K) in the PTEN gene in a Spanish patient with Cowden disease | Q64048441 | ||
| Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours | Q80128163 | ||
| Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage | Q80901395 | ||
| In silico investigation of molecular mechanism of laminopathy caused by a point mutation (R482W) in lamin A/C protein | Q85076680 | ||
| Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy. | Q36610138 | ||
| Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome | Q36718983 | ||
| Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs | Q36854122 | ||
| Targeting Akt in cancer therapy | Q36898418 | ||
| In silico prediction of a disease-associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ). | Q36917497 | ||
| Regulation of miR-19 to breast cancer chemoresistance through targeting PTEN | Q37148392 | ||
| The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications | Q37160617 | ||
| Computational SNP analysis: current approaches and future prospects | Q38121517 | ||
| Structural basis for the resilience of Darunavir (TMC114) resistance major flap mutations of HIV-1 protease | Q39283871 | ||
| TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP. | Q39451094 | ||
| Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. | Q39451375 | ||
| Computational investigation of cancer-associated molecular mechanism in Aurora A (S155R) mutation | Q39466789 | ||
| Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin | Q39497589 | ||
| Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers | Q39497597 | ||
| The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion | Q40085993 | ||
| Combined therapeutic effects of vinblastine and rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis | Q40112525 | ||
| Upstream signaling inhibition enhances rapamycin effect on growth of kidney cancer cells | Q40154994 | ||
| Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer | Q40183984 | ||
| Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors | Q40205287 | ||
| Signaling interactions of rapamycin combined with erlotinib in cervical carcinoma xenografts | Q40220268 | ||
| Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells | Q40243368 | ||
| Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells | Q40328451 | ||
| Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo | Q40384702 | ||
| Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and rapamycin | Q40399526 | ||
| Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma | Q40409431 | ||
| Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. | Q40457732 | ||
| Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis | Q40951921 | ||
| Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours | Q44079527 | ||
| Drug resistance mechanism of PncA in Mycobacterium tuberculosis | Q44227288 | ||
| Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. | Q44260429 | ||
| Investigation of binding phenomenon of NSP3 and p130Cas mutants and their effect on cell signalling | Q45282995 | ||
| Mutational analysis of TYR gene and its structural consequences in OCA1A. | Q45916214 | ||
| Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and Isoniazid susceptibility: an in silico analysis. | Q46000312 | ||
| Relationship between a point mutation S97C in CK1δ protein and its affect on ATP-binding affinity | Q48111017 | ||
| High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence | Q48558052 | ||
| miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics | Q21091130 | ||
| Foxo3a regulates apoptosis by negatively targeting miR-21 | Q24305974 | ||
| Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage | Q24537734 | ||
| Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells | Q24550891 | ||
| RNA and transcriptional modulation of gene expression | Q24605231 | ||
| A coding-independent function of gene and pseudogene mRNAs regulates tumour biology | Q24632651 | ||
| Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells | Q24646286 | ||
| Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells | Q24646815 | ||
| Molecular architecture of a miRNA-regulated 3' UTR | Q24649030 | ||
| The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo | Q24657924 | ||
| Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs | Q24671990 | ||
| The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia | Q28244041 | ||
| Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight | Q28293108 | ||
| Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain | Q28533515 | ||
| Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation | Q28638584 | ||
| MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer | Q29547523 | ||
| Exploiting the PI3K/AKT pathway for cancer drug discovery | Q29615120 | ||
| Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody | Q33389393 | ||
| The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway | Q33599964 | ||
| PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization | Q34150579 | ||
| Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma | Q34206363 | ||
| Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. | Q34330731 | ||
| A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer | Q34432863 | ||
| Targeting the Akt/mTOR pathway in Brca1-deficient cancers | Q35023287 | ||
| MicroRNA-7 inhibits the growth of human non-small cell lung cancer A549 cells through targeting BCL-2. | Q35098110 | ||
| PI3K/Akt signalling pathway and cancer. | Q35692250 | ||
| Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate | Q35838295 | ||
| GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells. | Q35853026 | ||
| AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. | Q35886886 | ||
| Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway | Q36100341 | ||
| Perturbations of the AKT signaling pathway in human cancer | Q36313181 | ||
| Akt-regulated pathways in prostate cancer | Q36313185 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | enzyme | Q8047 |
| targeted therapy | Q492646 | ||
| signal transduction | Q828130 | ||
| mechanism of action | Q3271540 | ||
| proto-oncogene protein | Q66020913 | ||
| pharmaceutical preparation | Q66089252 | ||
| neoplasm protein | Q66894191 | ||
| investigational drugs | Q76797059 | ||
| AKT serine/threonine kinase 1 | Q21114990 | ||
| P304 | page(s) | 756134 | |
| P577 | publication date | 2013-11-13 | |
| P1433 | published in | The Scientific World Journal | Q7762585 |
| P1476 | title | AKT kinase pathway: a leading target in cancer research. | |
| P478 | volume | 2013 |
| Q57297286 | A Visually Interpretable, Dictionary-Based Approach to Imaging-Genomic Modeling, With Low-Grade Glioma as a Case Study |
| Q34671334 | Activation of EGFR-PI3K-AKT signaling is required for Mycoplasma hyorhinis-promoted gastric cancer cell migration |
| Q57922223 | Antioxidant and Anticancer Roles of a Novel Strain of Isolated from Vermicompost Prepared from Paper Mill Sludge |
| Q44907312 | Clinical implication of Sox9 and activated Akt expression in pancreatic ductal adenocarcinoma |
| Q92153599 | Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni |
| Q91789473 | Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion |
| Q36288650 | Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways |
| Q49705802 | Gadd45β silencing impaired viability and metastatic phenotypes in cholangiocarcinoma cells by modulating the EMT pathway |
| Q36334890 | Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand |
| Q33976964 | HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. |
| Q96128206 | Inhibition of prostate cancer cell line (PC-3) by anhydrodihydroartemisinin (ADHA) through caspase-dependent pathway |
| Q33946055 | Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice |
| Q34545805 | MiR-133b regulates bladder cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1. |
| Q90734186 | MiR-21 Suppresses Anoikis through Targeting PDCD4 and PTEN in Human Esophageal Adenocarcinoma |
| Q34334470 | MiR-497 downregulation contributes to the malignancy of pancreatic cancer and associates with a poor prognosis |
| Q92839221 | MicroRNA-153 regulated AKT1 expression and suppressed cell proliferation of epithelial ovarian cancer cells |
| Q41827722 | Molecular Imaging for Comparison of Different Growth Factors on Bone Marrow-Derived Mesenchymal Stromal Cells' Survival and Proliferation In Vivo |
| Q27023899 | NEDD4: a promising target for cancer therapy |
| Q41487456 | Polymorphisms in epidermal growth factor receptor (EGFR) and AKT1 as possible predictors of clinical outcome in advanced non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors |
| Q35925830 | RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3. |
| Q91712845 | Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours |
| Q42317470 | SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1. |
| Q33623156 | Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways |
| Q43073881 | Time and flow-dependent changes in the p27(kip1) gene network drive maladaptive vascular remodeling |
| Q48220508 | microRNA-21 promotes osteogenic differentiation of mesenchymal stem cells by the PI3K/β-catenin pathway |
| Q35996844 | α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid |
Search more.