Targeting the Polyadenylation Signal of Pre-mRNA: A New Gene Silencing Approach for Facioscapulohumeral Dystrophy.

scientific article

Targeting the Polyadenylation Signal of Pre-mRNA: A New Gene Silencing Approach for Facioscapulohumeral Dystrophy. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/IJMS19051347
P932PMC publication ID5983732
P698PubMed publication ID29751519

P50authorRomain JoubertQ61825596
Virginie MariotQ89839658
P2093author name stringJulie Dumonceaux
Anne-Charlotte Marsollier
P2860cites workDUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1Q24299685
A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor ImQ24302567
The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNAQ24307893
The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3'-end of mRNAsQ36765062
Degradation of mRNAs that lack a stop codon: a decade of nonstop progressQ36802258
Mechanisms controlling production of membrane and secreted immunoglobulin during B cell developmentQ36818995
Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signalsQ36849107
Mutations in DNMT3B Modify Epigenetic Repression of the D4Z4 Repeat and the Penetrance of Facioscapulohumeral Dystrophy.Q36891155
Alternative polyadenylation sites reveal distinct chromatin accessibility and histone modification in human cell linesQ36985007
Protein factors in pre-mRNA 3'-end processing.Q37044967
Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.Q37080336
Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development.Q37160188
Sequence variation between 462 human individuals fine-tunes functional sites of RNA processingQ37248390
Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy TherapeuticsQ37256163
3' UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblastsQ37358020
Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.Q37475340
The myotonic dystrophies: molecular, clinical, and therapeutic challengesQ38045121
PABPN1: molecular function and muscle diseaseQ38100286
Molecular mechanisms in DM1 - a focus on foci.Q38326275
Correlation between low FAT1 expression and early affected muscle in facioscapulohumeral muscular dystrophyQ38505065
Evolution and Biological Roles of Alternative 3'UTRsQ38644580
CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα.Q38825492
Cleavage factor Im (CFIm) as a regulator of alternative polyadenylationQ38928598
Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursorsQ24309304
Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processingQ24313447
Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunitsQ24313453
The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formationQ24314710
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAsQ24315942
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sitesQ24317135
Participation of the nuclear cap binding complex in pre-mRNA 3' processingQ24320261
Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA loopingQ24338977
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machineryQ24534097
Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription terminationQ24534246
Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymeraseQ24535920
Complex protein interactions within the human polyadenylation machinery identify a novel componentQ24554306
A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100Q24557030
A large-scale analysis of mRNA polyadenylation of human and mouse genesQ24557438
Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3' processing signal AAUAAAQ24564625
Assembly of a processive messenger RNA polyadenylation complexQ24564750
Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTDQ24601077
U1 snRNP determines mRNA length and regulates isoform expressionQ24623251
Patterns of variant polyadenylation signal usage in human genesQ24624061
RNA recognition by the human polyadenylation factor CstFQ24646013
3' end mRNA processing: molecular mechanisms and implications for health and diseaseQ24648650
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sitesQ24653978
Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 proteinQ24671232
Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expressionQ24796373
Poly(A) polymerase (PAP) diversity in gene expression--star-PAP vs canonical PAPQ26991894
Antisense oligonucleotides: treating neurodegeneration at the level of RNAQ27007056
Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophyQ27322323
Crystal structure of the 25 kDa subunit of human cleavage factor ImQ27650479
Hexameric architecture of CstF supported by CstF-50 homodimerization domain structureQ27666576
A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA ProcessingQ27676995
Dysregulation of 4q35- and muscle-specific genes in fetuses with a short D4Z4 array linked to facio-scapulo-humeral dystrophy.Q50738350
Antisense targeting of 3' end elements involved in DUX4 mRNA processing is an efficient therapeutic strategy for facioscapulohumeral dystrophy: a new gene-silencing approach.Q50889865
Computer-based assessment for facioscapulohumeral dystrophy diagnosis.Q50925534
A distal auxiliary element facilitates cleavage and polyadenylation of Dux4 mRNA in the pathogenic haplotype of FSHD.Q50982781
An ordered pathway of assembly of components required for polyadenylation site recognition and processing.Q51172966
Nuclear protein spreading: implication for pathophysiology of neuromuscular diseases.Q54365453
Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length.Q55056466
Primary structure and expression of bovine poly(A) polymeraseQ59097203
Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit beta-globin mRNA 3' end formationQ68985721
Facioscapulohumeral muscular dystrophyQ82663047
Differential DNA methylation of the D4Z4 repeat in patients with FSHD and asymptomatic carriersQ87405047
Global 3' UTR shortening has a limited effect on protein abundance in proliferating T cellsQ38938771
Cleavage and polyadenylation: Ending the message expands gene regulationQ39269835
The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.Q39364902
Alternative polyadenylation mediates microRNA regulation of muscle stem cell functionQ39386660
De-regulation of the RBBP6 isoform 3/DWNN in human cancersQ39433404
A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence.Q39722557
Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA.Q39790864
Two G-rich regulatory elements located adjacent to and 440 nucleotides downstream of the core poly(A) site of the intronless melanocortin receptor 1 gene are critical for efficient 3' end processingQ40190265
In vivo aggregation properties of the nuclear poly(A)-binding protein PABPN1.Q40438611
Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cellsQ40979450
Genome Therapy of Myotonic Dystrophy Type 1 iPS Cells for Development of Autologous Stem Cell TherapyQ41092886
Ribosome-associated complex and Ssb are required for translational repression induced by polylysine segments within nascent chainsQ41170166
A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAsQ41656652
Purification and characterization of a mammalian polyadenylate polymerase involved in the 3' end processing of messenger RNA precursors.Q41767252
Molecular architecture of the human pre-mRNA 3' processing complexQ42418612
Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylationQ42868459
The beta-adrenergic system is involved in the regulation of the expression of avian uncoupling protein in the chicken.Q43270931
Four factors are required for 3'-end cleavage of pre-mRNAsQ43727383
mTOR as a Key Regulator in Maintaining Skeletal Muscle MassQ44682872
The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutationsQ44826905
A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylationQ45284501
Androgen receptors and muscle: a key mechanism underlying life history trade-offs.Q46276412
Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative PolyadenylationQ47256963
Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complexQ47258918
The distinct transcriptomes of slow and fast adult muscles are delineated by noncoding RNAs.Q47590628
Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiationQ47864682
mRNA 3'-UTR shortening is a molecular signature of mTORC1 activationQ48173809
Cleavage factor Im is a key regulator of 3' UTR lengthQ50320383
3' non-coding region sequences in eukaryotic messenger RNAQ27860858
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.Q27932064
Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription terminationQ27933119
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.Q27934493
The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation siteQ28082339
The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppressionQ28205420
Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNAQ28249862
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonucleaseQ28275724
A unifying genetic model for facioscapulohumeral muscular dystrophyQ28291033
Expression of two protein isoforms of PAX7 is controlled by competing cleavage-polyadenylation and splicingQ28291809
The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiationQ28298568
The C-terminal domain of RNA polymerase II couples mRNA processing to transcriptionQ28301744
Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesisQ28609911
5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase IIQ28623635
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylationQ29032058
RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophyQ29036117
Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2Q29303884
DUX4 and DUX4 downstream target genes are expressed in fetal FSHD musclesQ29391941
RNA polymerase II and the integration of nuclear eventsQ29614772
RNA polymerase II is an essential mRNA polyadenylation factorQ29614773
Mechanism and regulation of mRNA polyadenylationQ29614774
Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophyQ30039698
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancerQ30485336
Heterogeneity in polyadenylation cleavage sites in mammalian mRNA sequences: implications for SAGE analysis.Q30663306
A downstream polyadenylation element in human papillomavirus type 16 L2 encodes multiple GGG motifs and interacts with hnRNP H.Q30789709
Aberrant herpesvirus-induced polyadenylation correlates with cellular messenger RNA destructionQ30863867
A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylationQ31112743
Reprogramming of 3' untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell typesQ33520920
Human skeletal muscle xenograft as a new preclinical model for muscle disordersQ33649287
Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis.Q33697689
Upper girdle imaging in facioscapulohumeral muscular dystrophyQ33763548
Global analyses of the effect of different cellular contexts on microRNA targetingQ33773060
Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulationQ33871092
Contractions of D4Z4 on 4qB subtelomeres do not cause facioscapulohumeral muscular dystrophy.Q33910577
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.Q33968674
Regulation of alternative polyadenylation by genomic imprintingQ34011433
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.Q34027447
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' endsQ34056363
DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscleQ34211798
An RNA polymerase pause site is associated with the immunoglobulin mus poly(A) siteQ34283461
RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRsQ34360775
Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKRQ34362347
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processingQ34430715
Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33.Q34430722
Interactions of CstF-64, CstF-77, and symplekin: implications on localisation and function.Q34471019
Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.Q34473863
Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures.Q34759787
Cleavage site determinants min the mammalian polydenylation signalQ34762164
Splicing factor ASF/SF2 and transcription factor PPAR-gamma cooperate to directly regulate transcription of uncoupling protein-3.Q34900774
RNA polymerase II kinetics in polo polyadenylation signal selection.Q35048913
The nucleosome regulates the usage of polyadenylation sites in the human genomeQ35074663
Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylationQ35532398
Structure and function of poly(A) binding proteinsQ35781035
A quantitative atlas of polyadenylation in five mammalsQ36021683
Implications of polyadenylation in health and diseaseQ36189648
GC skew defines distinct RNA polymerase pause sites in CpG island promotersQ36199553
Poly(A) binding protein nuclear 1 levels affect alternative polyadenylationQ36305636
Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation.Q36406071
Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylationQ36414738
Analysis of alternative cleavage and polyadenylation by 3' region extraction and deep sequencing.Q36575994
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmessenger RNAQ188928
gene silencingQ1431332
P577publication date2018-05-03
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleTargeting the Polyadenylation Signal of Pre-mRNA: A New Gene Silencing Approach for Facioscapulohumeral Dystrophy.
P478volume19

Reverse relations

cites work (P2860)
Q94586107RNA modifications in brain tumorigenesis
Q64226580SMCHD1 is involved in de novo methylation of the DUX4-encoding D4Z4 macrosatellite

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