Molecular architecture of the human pre-mRNA 3' processing complex

scientific article published on February 2009

Molecular architecture of the human pre-mRNA 3' processing complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2008.12.028
P8608Fatcat IDrelease_44ax5eu32vaafaz3el64ek4m5y
P932PMC publication ID2946185
P698PubMed publication ID19217410
P5875ResearchGate publication ID24010659

P50authorJames L. ManleyQ38362017
P2093author name stringJoachim Frank
John R Yates
Ali Sarkeshik
Derek Taylor
William J Rice
Yongsheng Shi
Dafne Campigli Di Giammartino
P2860cites workDWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.Q21256424
Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factorsQ24290465
Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumorsQ24291467
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysisQ24296676
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexesQ24298731
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase IIQ24338780
Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognitionQ24529123
Complex protein interactions within the human polyadenylation machinery identify a novel componentQ24554306
Recognition of polyadenylate RNA by the poly(A)-binding proteinQ27619753
Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATPQ27626471
Structure of yeast poly(A) polymerase alone and in complex with 3'-dATPQ27626696
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditionsQ38406412
The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicingQ40442143
Where transcription meets repairQ40739628
Three-dimensional structure of the large ribosomal subunit from Escherichia coli.Q41339414
GraFix: sample preparation for single-particle electron cryomicroscopyQ41623539
Four factors are required for 3'-end cleavage of pre-mRNAsQ43727383
Purification of the cleavage and polyadenylation factor involved in the 3'-processing of messenger RNA precursors.Q44234133
U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymeraseQ47862801
FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition.Q52104057
Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3' end processing and splicing.Q53610010
A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets.Q53652090
Regulation of yeast mRNA 3' end processing by phosphorylation.Q53658895
Primary structure and expression of bovine poly(A) polymeraseQ59097203
A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAsQ68164668
Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymusQ68214796
Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylationQ69820089
The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processingQ79372264
PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteinsQ80263517
Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factorQ27643230
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursorsQ27644241
The structure of the CstF-77 homodimer provides insights into CstF assemblyQ27646266
Structure of the N-Terminal Mlp1-Binding Domain of the Saccharomyces cerevisiae mRNA-Binding Protein, Nab2Q27649526
Crystal structure of the 25 kDa subunit of human cleavage factor ImQ27650479
Structure of Yeast Poly(A) Polymerase in Complex with a Peptide from Fip1, an Intrinsically Disordered Protein † ‡Q27650771
EMAN: semiautomated software for high-resolution single-particle reconstructionsQ27860772
Mpe1, a zinc knuckle protein, is an essential component of yeast cleavage and polyadenylation factor required for the cleavage and polyadenylation of mRNA.Q27929802
Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I.Q27933038
Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiaeQ27934513
The WD-repeat protein pfs2p bridges two essential factors within the yeast pre-mRNA 3'-end-processing complexQ27936005
Comprehensive proteomic analysis of the human spliceosomeQ28201545
The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppressionQ28205420
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonucleaseQ28275724
Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiationQ28293560
The C-terminal domain of RNA polymerase II couples mRNA processing to transcriptionQ28301744
PACT: cloning and characterization of a cellular p53 binding protein that interacts with RbQ28302250
Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesisQ28609911
Integrating mRNA processing with transcriptionQ28610124
An extensive network of coupling among gene expression machinesQ29547273
RNA polymerase II and the integration of nuclear eventsQ29614772
RNA polymerase II is an essential mRNA polyadenylation factorQ29614773
Mechanism and regulation of mRNA polyadenylationQ29614774
Direct analysis of protein complexes using mass spectrometryQ29617450
RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes.Q34009055
A novel nuclear human poly(A) polymerase (PAP), PAP gammaQ34082550
Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factorsQ34331986
cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene productQ34374596
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cellsQ36380143
The 3' processing factor CstF functions in the DNA repair responseQ36580663
Protein factors in pre-mRNA 3'-end processing.Q37044967
Grabbing the message: structural basis of mRNA 3'UTR recognition by Hrp1Q38312118
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)365-376
P577publication date2009-02-01
P1433published inMolecular CellQ3319468
P1476titleMolecular architecture of the human pre-mRNA 3' processing complex
P478volume33

Reverse relations

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Q37408113Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.
Q29541446Transcription termination by nuclear RNA polymerases
Q40339336Transcriptional activators enhance polyadenylation of mRNA precursors.
Q35458713Transcriptional activity regulates alternative cleavage and polyadenylation
Q26862917Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity
Q59884668Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma
Q35195969Transcriptome dynamics through alternative polyadenylation in developmental and environmental responses in plants revealed by deep sequencing.
Q36414738Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation
Q36510112Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer
Q36684834UV damage regulates alternative polyadenylation of the RPB2 gene in yeast.
Q42633493Unique features of plant cleavage and polyadenylation specificity factor revealed by proteomic studies
Q37864536Unravelling the means to an end: RNA polymerase II transcription termination.
Q92217036Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control
Q50064038Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity
Q27933667Yeast transcription termination factor Rtt103 functions in DNA damage response
Q37263272eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts.
Q41569819mRNA 3' end processing factors: a phylogenetic comparison
Q24601240mRNA 3'end processing: A tale of the tail reaches the clinic
Q39579705p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex
Q36419865period-1 encodes an ATP-dependent RNA helicase that influences nutritional compensation of the Neurospora circadian clock
Q47214605snoRNAs associate with mRNA 3' processing complex: New wine in old bottles.
Q36978280αCP Poly(C) binding proteins act as global regulators of alternative polyadenylation