StpA and Hha stimulate pausing by RNA polymerase by promoting DNA-DNA bridging of H-NS filaments.

scientific article published in June 2018

StpA and Hha stimulate pausing by RNA polymerase by promoting DNA-DNA bridging of H-NS filaments. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKY265
P932PMC publication ID6009659
P698PubMed publication ID29718386

P50authorRamon A van der ValkQ130272141
Remus T DameQ38305121
P2093author name stringLiang Qin
Robert Landick
Matthew V Kotlajich
Beth A Boudreau
Daniel R Hron
P2860cites workExpression of the hemolysin operon in Escherichia coli is modulated by a nucleoid-protein complex that includes the proteins Hha and H-NSQ73706944
Osmolarity modulates the expression of the Hha protein from Escherichia coliQ74526725
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Horizontally acquired homologues of the nucleoid-associated protein H-NS: implications for gene regulationQ82263480
Enhancing transcription through the Escherichia coli hemolysin operon, hlyCABD: RfaH and upstream JUMPStart DNA sequences function together via a postinitiation mechanismQ24678566
The bacterial nucleoid: nature, dynamics and sister segregationQ26825279
Structure of the nucleoid-associated protein Cnu reveals common binding sites for H-NS in Cnu and HhaQ27649524
H-NS forms a superhelical protein scaffold for DNA condensationQ27664196
Indirect DNA Readout by an H-NS Related Protein: Structure of the DNA Complex of the C-Terminal Domain of LerQ27675789
Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS ComplexQ27676910
Solution structure of the DNA binding domain of a nucleoid-associated protein, H-NS, from Escherichia coliQ27730385
Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genomeQ28265807
H-NS mediates the silencing of laterally acquired genes in bacteriaQ28490022
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Supercoiling of the DNA template during transcriptionQ29617503
Bacterial chromatin organization by H-NS protein unravelled using dual DNA manipulationQ33263766
Gre factors-mediated control of hilD transcription is essential for the invasion of epithelial cells by Salmonella enterica serovar Typhimurium.Q33585337
Differential effects and interactions of endogenous and horizontally acquired H-NS-like proteins in pathogenic Escherichia coliQ33621541
A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modes.Q33631136
Growth phase-dependent variation in protein composition of the Escherichia coli nucleoidQ33638020
The bacterial DNA-binding protein H-NS represses ribosomal RNA transcription by trapping RNA polymerase in the initiation complexQ33901055
A pause sequence enriched at translation start sites drives transcription dynamics in vivoQ33939698
Novel role for a bacterial nucleoid protein in translation of mRNAs with suboptimal ribosome-binding sitesQ33953614
DNA looping-mediated repression by histone-like protein H-NS: specific requirement of Esigma70 as a cofactor for loopingQ34055951
Role of the Hha/YmoA family of proteins in the thermoregulation of the expression of virulence factorsQ34118025
Repression by binding of H-NS within the transcription unit.Q52579807
YdgT, the Hha paralogue in Escherichia coli, forms heteromeric complexes with H-NS and StpA.Q54498518
The transcriptional regulator RfaH stimulates RNA chain synthesis after recruitment to elongation complexes by the exposed nontemplate DNA strand.Q54545830
Transcript cleavage factors from E. coli.Q54662145
A quantitative assessment for transcriptional pausing of DNA-dependent RNA polymerases in vitro.Q54709600
Multimeric Self-assembly Equilibria Involving the Histone-like Protein H-NS: A THERMODYNAMIC STUDYQ56838392
Expression of the Escherichia coli ompW colicin S4 receptor gene is regulated by temperature and modulated by the H-NS and StpA nucleoid-associated proteinsQ57752123
New Roles for Key Residues in Helices H1 and H2 of the Escherichia coli H-NS N-terminal Domain: H-NS Dimer Stabilization and Hha BindingQ57962553
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Donation of catalytic residues to RNA polymerase active center by transcription factor GreQ34788277
Role of histone-like proteins H-NS and StpA in expression of virulence determinants of uropathogenic Escherichia coliQ34976630
Bridged filaments of histone-like nucleoid structuring protein pause RNA polymerase and aid termination in bacteriaQ35111368
Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signalsQ35152961
Silencing by H-NS potentiated the evolution of SalmonellaQ35398967
H-NS in Gram-negative bacteria: a family of multifaceted proteinsQ35579488
RfaH enhances elongation of Escherichia coli hlyCABD mRNA.Q35604432
Differential protease-mediated turnover of H-NS and StpA revealed by a mutation altering protein stability and stationary-phase survival of Escherichia coliQ35631720
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Gene silencing H-NS paralogue StpA forms a rigid protein filament along DNA that blocks DNA accessibilityQ35906107
Gene Activation through the Modulation of Nucleoid Structures by a Horizontally Transferred Regulator, Pch, in Enterohemorrhagic Escherichia coliQ35930931
Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencingQ36093140
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Rho and NusG suppress pervasive antisense transcription in Escherichia coliQ36464974
Transcriptional Regulation of the Outer Membrane Porin Gene ompW Reveals its Physiological Role during the Transition from the Aerobic to the Anaerobic Lifestyle of Escherichia coliQ36950511
The quantitative and condition-dependent Escherichia coli proteomeQ36956238
Anti-silencing: overcoming H-NS-mediated repression of transcription in Gram-negative enteric bacteriaQ37256199
Mica functionalization for imaging of DNA and protein-DNA complexes with atomic force microscopyQ37359552
A mutational study of Cnu reveals attractive forces between Cnu and H-NS.Q37461517
Widespread suppression of intragenic transcription initiation by H-NS.Q37582976
Cellular strategies for regulating DNA supercoiling: a single-molecule perspectiveQ37781144
Silencing of foreign DNA in bacteriaQ37977667
The Type 1 secretion pathway - the hemolysin system and beyondQ38152930
A molecular mechanism for the repression of transcription by the H-NS proteinQ38291337
Growth phase dependent changes in the structure and protein composition of nucleoid in Escherichia coliQ38297452
The nucleoid-associated protein StpA binds curved DNA, has a greater DNA-binding affinity than H-NS and is present in significant levels in hns mutantsQ38302753
Association of nucleoid proteins with coding and non-coding segments of the Escherichia coli genome.Q38309827
Selective silencing of foreign DNA with low GC content by the H-NS protein in SalmonellaQ38312504
The virF promoter in Shigella: more than just a curved DNA stretchQ38345190
The oligomeric structure of nucleoid protein H-NS is necessary for recognition of intrinsically curved DNA and for DNA bending.Q38347186
Differential binding profiles of StpA in wild-type and h-ns mutant cells: a comparative analysis of cooperative partners by chromatin immunoprecipitation-microarray analysis.Q38357348
Differential dependence of StpA on H-NS in autoregulation of stpA and in regulation of bgl.Q38503832
The Impact of Gene Silencing on Horizontal Gene Transfer and Bacterial EvolutionQ38976154
Compromised factor-dependent transcription termination in a nusA mutant of Escherichia coli: spectrum of termination efficiencies generated by perturbations of Rho, NusG, NusA, and H-NS family proteinsQ39265509
Modulation of Rho-dependent transcription termination in Escherichia coli by the H-NS family of proteinsQ39265512
H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.Q39497729
Heteromeric interactions among nucleoid-associated bacterial proteins: localization of StpA-stabilizing regions in H-NS of Escherichia coliQ39503249
H-NS mediated compaction of DNA visualised by atomic force microscopyQ39584438
Temperature- and H-NS-dependent regulation of a plasmid-encoded virulence operon expressing Escherichia coli hemolysinQ39680198
Increased bending rigidity of single DNA molecules by H-NS, a temperature and osmolarity sensorQ40233805
Nucleotide sequence of a newly-identified Escherichia coli gene, stpA, encoding an H-NS-like protein.Q40536273
Hha has a defined regulatory role that is not dependent upon H-NS or StpA.Q40631297
Coordinated and differential expression of histone-like proteins in Escherichia coli: regulation and function of the H-NS analog StpA.Q41077231
A biomechanical mechanism for initiating DNA packaging.Q41769391
DNA bridging: a property shared among H-NS-like proteinsQ41844405
RNA chaperone activity and RNA-binding properties of the E. coli protein StpA.Q41900272
Direct and indirect effects of H-NS and Fis on global gene expression control in Escherichia coliQ42113114
Functions of the Hha and YdgT proteins in transcriptional silencing by the nucleoid proteins, H-NS and StpA, in Escherichia coliQ42168572
Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activityQ42380111
Protein-mediated molecular bridging: a key mechanism in biopolymer organizationQ42575832
The hha gene modulates haemolysin expression in Escherichia coliQ42625501
Transcription under torsionQ42627110
Structural basis for H-NS-mediated trapping of RNA polymerase in the open initiation complex at the rrnB P1.Q42664136
High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomesQ42734633
Molecular evolution of the H-NS protein: interaction with Hha-like proteins is restricted to enterobacteriaceaeQ42957507
Thermosensing coordinates a cis-regulatory module for transcriptional activation of the intracellular virulence system in Salmonella enterica serovar TyphimuriumQ43223227
The H-NS-like protein StpA represses the RpoS (sigma 38) regulon during exponential growth of Salmonella Typhimurium.Q43258215
Genomic analysis reveals epistatic silencing of "expensive" genes in Escherichia coli K-12.Q45943343
The Hha protein facilitates incorporation of horizontally acquired DNA in enteric bacteriaQ46262032
Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells.Q47433869
The histone-like nucleoid structuring protein H-NS represses the Escherichia coli bgl operon downstream of the promoterQ47814123
Biophysical compensation mechanisms buffering E. coli protein-nucleic acid interactions against changing environmentsQ48014911
A bacterial gene involved in transcription antitermination: regulation at a rho-independent terminator in the bgl operon of E. coliQ48341103
Investigation of the self-association and hetero-association interactions of H-NS and StpA from EnterobacteriaQ50054725
Interference of transcription across H-NS binding sites and repression by H-NS.Q50100649
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)5525-5546
P577publication date2018-06-01
P1433published inNucleic Acids ResearchQ135122
P1476titleStpA and Hha stimulate pausing by RNA polymerase by promoting DNA-DNA bridging of H-NS filaments
P478volume46

Reverse relations

cites work (P2860)
Q91452344Chromosome organization in bacteria: mechanistic insights into genome structure and function
Q61821275H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing
Q92572722High-Resolution Mapping of the Escherichia coli Chromosome Reveals Positions of High and Low Transcription
Q90561758NusG prevents transcriptional invasion of H-NS-silenced genes
Q90929933RNA synthesis is a team effort
Q90629750Salmonella expresses foreign genes during infection by degrading their silencer
Q92565084Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins
Q91650136The architects of bacterial DNA bridges: a structurally and functionally conserved family of proteins

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